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Shikonin Induced Necroptosis via Reactive Oxygen Species in the T-47D Breast Cancer Cell Line
Shahsavari, Zahra,Karami-Tehrani, Fatemeh,Salami, Siamak Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.16
Breast cancer, the most common cancer in the women, is the leading cause of death. Necrotic signaling pathways will enable targeted therapeutic agents to eliminate apoptosis-resistant cancer cells. In the present study, the effect of shikonin on the induction of cell necroptosis or apoptosis was evaluated using the T-47D breast cancer cell line. The cell death modes, caspase-3 and 8 activities and the levels of reactive oxygen species (ROS) were assessed. Cell death mainly occurred through necroptosis. In the presence of Nec-1, caspase-3 mediated apoptosis was apparent in the shikonin treated cells. Shikonin stimulates ROS generation in the mitochondria of T-47D cells, which causes necroptosis or apoptosis. Induction of necroptosis, as a backup-programmed cell death pathway via ROS stimulation, offers a new strategy for the treatment of breast cancer.
Shahsavari Alavijeh Mohammadhossein,Maghsoudpour Adel,Khayat Morteza,Rad Iman,Hatamie Shadie 한국약제학회 2020 Journal of Pharmaceutical Investigation Vol.50 No.6
Purpose Aims were to investigate pattern of distribution of “molybdenum disulfide/cobalt ferrite” magnetic nanocomposite (MNC), following injection into the BALB/c mice tumor. Methods MNCs were characterized by microscopic, spectroscopic and magneto-metric techniques. To have a gland tumor, 4T1 cells injected subcutaneously. After 1 week of tumor growth, MNCs injected to the tumor at different speed rates, and tumor size monitored after magnetic fluid hyperthermia (MFH) by seven days via measurement of tumors’ outer dimensions, histopathology and qRT-PCR assay techniques. Results Neither MoS2/ CoFe2O4 nor applied alternative magnetic field (AMF) diminished viability of tumor cells. However, when concentration of 200 μg/ml injected by speed rate of 10 μl/min to the tumor in the presence of AMF (f = 150 kHz, H = 31.16 mT), significant diminution of tumor size and considerable raise of tumor necrosis observed. At the same time, up-regulation of Bax and p53, and down-regulation of VEGF and Bcl2 was detected. Conclusion Uniform distribution of MNC in optimized condition resulted in significant diminution of tumor size after MFH. Besides, injection of MoS2/ CoFe2O4 to the tumor left no sign of necrosis or inflammation in the mice liver. These features of MoS2/ CoFe2O4 introduce it as a promising candidate for further clinical studies.
Size-dependent vibration analysis of laminated composite plates
Shahsavari, Davood,Karami, Behrouz,Janghorban, Maziar Techno-Press 2019 Advances in nano research Vol.7 No.5
The size-dependent vibration analysis of a cross-/angle-ply laminated composite plate when embedded on the Pasternak elastic foundation and exposed to an in-plane magnetic field are investigated by adopting an analytical eigenvalue approach. The formulation, which is based on refined-hyperbolic-shear-deformation-plate theory in conjunction with the Eringen Nonlocal Differential Model (ENDM), is tested against considering problems for which numerical/analytical solutions available in the literature. The findings of this study demonstrated the role of magnetic field, size effect, elastic foundation coefficients, geometry, moduli ratio, lay-up numbers and fiber orientations on the nonlocal frequency of cross-/angle-ply laminated composite plates.
On buckling analysis of laminated composite plates using a nonlocal refined four-variable model
Davood Shahsavari,Behrouz Karami,Maziar Janghorban 국제구조공학회 2019 Steel and Composite Structures, An International J Vol.32 No.2
This study is concerned with the stability of laminated composite plates modelled using Eringen’s nonlocal differential model (ENDM) and a novel refined-hyperbolic-shear-deformable plate theory. The plate is assumed to be lying on the Pasternak elastic foundation and is under the influence of an in-plane magnetic field. The governing equations and boundary conditions are obtained through Hamilton’s principle. An analytical approach considering Navier series is used to fine the critical bucking load. After verifying with existing results for the reduced cases, the present model is then used to study buckling of the laminated composite plate. Numerical results demonstrate clearly for the first time the roles of size effects, magnetic field, foundation parameters, moduli ratio, geometry, lay-up numbers and sequences, fiber orientations, and boundary conditions. These results could be useful for designing better composites and can further serve as benchmarks for future studies on the laminated composite plates.
Amirreza Shahsavari(아미레자 샤사바리),Mahdi Nili-Ahmadabadi(마흐디 닐리-아마다바디),Kyung Chun Kim(김경천) 대한기계학회 2020 대한기계학회 춘추학술대회 Vol.2020 No.12
The present study attempts to improve the aerodynamic performance of a slender delta wing. In this study, the effect of needle vortex generators on the flow of a delta wing with a sweep angle of 65° was studied. The experiments were performed at AOA= 20 degrees at a speed of 2.6 m/s on two delta wings with and without equipped needle vortex generators at the leading edge and a Reynolds number of Re = 2.6 × 10⁴. Smoke and laser flow visualization were used to understand the effect of the vortex generator on the flow over the delta wing at six different sections of the delta wing. The results showed that the use of the needle vortex generators along the leading edge of the delta wing makes the vortices smaller and closer to the wing surface. The needle vortex generators on the leading edge also cause the vortex breakdown to postpone.
A high-order gradient model for wave propagation analysis of porous FG nanoplates
Davood Shahsavari,Behrouz Karami,Li Li 국제구조공학회 2018 Steel and Composite Structures, An International J Vol.29 No.1
A high-order nonlocal strain gradient model is developed for wave propagation analysis of porous FG nanoplates resting on a gradient hybrid foundation in thermal environment, for the first time. Material properties are assumed to be temperature-dependent and graded in the nanoplate thickness direction. To consider the thermal effects, uniform, linear, nonlinear, exponential, and sinusoidal temperature distributions are considered for temperature-dependent FG material properties. On the basis of the refined-higher order shear deformation plate theory (R-HSDT) in conjunction with the bi-Helmholtz nonlocal strain gradient theory (B-H NSGT), Hamilton's principle is used to derive the equations of wave motion. Then the dispersion relation between frequency and wave number is solved analytically. The influences of various parameters (such as temperature rise, volume fraction index, porosity volume fraction, lower and higher order nonlocal parameters, material characteristic parameter, foundations components, and wave number) on the wave propagation behaviors of porous FG nanoplates are investigated in detail.
Mohammadhossein Shahsavari Alavijeh,Adel Maghsoudpour,Morteza Khayat,Iman Rad,Shadie Hatamie 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.3
The aims were to characterize MoS 2 /CoFe 2 O 4 nanocomposite and investigate its thermal therapy efficiency on cancerous (MCF-7) and normal (MCF-10A) human breast cells. Magnetic nanocomposites (MNCs) characterized by scanning/transmission electron microscopy (SEM/TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and vibrating sample magnetometer (VSM) techniques. TEM and SEM techniques showed MoS 2 /CoFe 2 O 4 MNCs had an average size of 17±4 nm with almost spherical morphology. Magnetic properties of MNC measured by VSM, which resulted in specific loss power (SLP) of 766.61 W/g at 300 K. Cytotoxicity of MoS 2 /CoFe 2 O 4 nanocomposites in MCF-7 and MCF-10A cell lines remained insignificant until 48 hours, which confirms its biocompatibility. Low concentration (200 µg/mL) of MoS 2 /CoFe 2 O 4 was exposed to the low-frequency alternative magnetic field (f = 150 kHz, H = 31.16 mT) in a way that delivery of thermal ablation via magnetic fluid hyperthermia (MFH) occurred exclusively in cancerous (MCF-7) cells.
Antibacterial properties of ferrimagnetic and superparamagnetic nanoparticles: a comparative study
Mohammadhossein Shahsavari Alavijeh,Milad Salimi Bani,Iman Rad,Shadie Hatamie,Mahsa Soufi Zomorod,Mohammad Haghpanahi 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.2
In this study, antibacterial impact of magnetic nanocomposite (MNC: MoS2 /CoFe2O4) and super paramagnetic iron oxide nanoparticle (SPION: Fe3O4 -Casein) against staphylococcus aureus was studied. It was expected that such comparative study, address key points in optimization of synthesis and design of nanomaterials, which are supposed to be used as antibacterial agents for magnetic fluid hyperthermia (MFH) purposes. As the results, the MNC and SPION had average sizes of 17±4 nm and 15±5 nm, and diffused homogenously in agarose gel. They both were bacteriostatic against S. aureus at very low concentrations, while were bactericidal at concentrations of 200 µg/mL and more in MFH condition. In conclusion, both MNC and SPION inhibit S. aureus viability when low amplitude (H = 31.16 mT) alternative magnetic field (AMF: f = 150 kHz) was applied. Therefore, both of the nanomaterials are eligible to be considered as antibacterial candidates for treatment of complicated infections in upper respiratory tract or skin.