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- 저자 : Seungwon Shin (검색결과 236 건)
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An Seungwon,Nedumaran Balachandar,Koh Hong,Joo Dong Jin,Lee Hyungjo,Park Chul-Seung,Harris Robert A.,Shin Keong Sub,Djalilian Ali R.,Kim Yong Deuk 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Melatonin is involved in the regulation of various biological functions. Here, we explored a novel molecular mechanism by which the melatonin-induced sestrin2 (SESN2)-small heterodimer partner (SHP) signaling pathway protects against fasting- and diabetes-mediated hepatic glucose metabolism. Various key gene expression analyses were performed and multiple metabolic changes were assessed in liver specimens and primary hepatocytes of mice and human participants. The expression of the hepatic cereblon (CRBN) and b-cell translocation gene 2 (BTG2) genes was significantly increased in fasting mice, diabetic mice, and patients with diabetes. Overexpression of Crbn and Btg2 increased hepatic gluconeogenesis by enhancing cyclic adenosine monophosphate (cAMP)-responsive element-binding protein H (CREBH), whereas this phenomenon was prominently ablated in Crbn null mice and Btg2-silenced mice. Interestingly, melatonin-induced SESN2 and SHP markedly reduced hepatic glucose metabolism in diabetic mice and primary hepatocytes, and this protective effect of melatonin was strikingly reversed by silencing Sesn2 and Shp. Finally, the melatonin-induced SESN2-SHP signaling pathway inhibited CRBN- and BTG2-mediated hepatic gluconeogenic gene transcription via the competition of BTG2 and the interaction of CREBH. Mitigation of the CRBN-BTG2-CREBH axis by the melatonin-SESN2-SHP signaling network may provide a novel therapeutic strategy to treat metabolic dysfunction due to diabetes.
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A hybrid interface tracking – level set technique for multiphase flow with soluble surfactant
Shin, Seungwon,Chergui, Jalel,Juric, Damir,Kahouadji, Lyes,Matar, Omar K.,Craster, Richard V. Elsevier 2018 Journal of computational physics Vol.359 No.-
<P><B>Abstract</B></P> <P>A formulation for soluble surfactant transport in multiphase flows recently presented by Muradoglu and Tryggvason (JCP 274 (2014) 737–757) is adapted to the context of the Level Contour Reconstruction Method, LCRM, (Shin et al. IJNMF 60 (2009) 753–778, ) which is a hybrid method that combines the advantages of the Front-tracking and Level Set methods. Particularly close attention is paid to the formulation and numerical implementation of the surface gradients of surfactant concentration and surface tension. Various benchmark tests are performed to demonstrate the accuracy of different elements of the algorithm. To verify surfactant mass conservation, values for surfactant diffusion along the interface are compared with the exact solution for the problem of uniform expansion of a sphere. The numerical implementation of the discontinuous boundary condition for the source term in the bulk concentration is compared with the approximate solution. Surface tension forces are tested for Marangoni drop translation. Our numerical results for drop deformation in simple shear are compared with experiments and results from previous simulations. All benchmarking tests compare well with existing data thus providing confidence that the adapted LCRM formulation for surfactant advection and diffusion is accurate and effective in three-dimensional multiphase flows with a structured mesh. We also demonstrate that this approach applies easily to massively parallel simulations.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Extension of the LCRM Front-tracking method (Shin et al. IJNMF 60 (2009) 753–778) to flows with surfactant. </LI> <LI> Following Muradoglu and Tryggvason (JCP 274 (2014) 737–757) surfactant transport is solved on the interface and in the bulk. </LI> <LI> Accuracy demonstrated for mass conservation, surface advection and diffusion, bulk transport and Marangoni stresses. </LI> <LI> Large scale parallel calculations of two-phase annular film flow in the counter-current flow regime. </LI> </UL> </P>
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On the validity of archeomagnetic dating method in Korea: a case study
Seungwon Shin,Yong-Hee Park,Daekyo Cheong,Sook Chung Shin 한국지질과학협의회 2018 Geosciences Journal Vol.22 No.1
An archeomagnetic study has been performed for six archeological relics of the Proto-Three Kingdoms period excavated in Jungdo Island, South Korea. Among a total of 90 samples from hearths remains of six dwelling sites, the characteristic remanent magnetization components were isolated from 70 samples using the progressive alternating field demagnetizations and considered to record faithfully a thermoremanent magnetization at the timing of the last cooling of the hearths. Two different approaches were made to determine the archeomagnetic ages: One is the conventional method using the relocated paleosecular variation (PSV) curve obtained from southwestern Japan. The other method adopts a Matlab archaeo_dating tool using a Bayesian statistics with global geomagnetic field prediction model (ARCH3K.1). Both archeomagnetic ages using two individual dating methods generally overlapped with the radiocarbon age ranges for each sites. However, no systematic relationship between archeomagnetic ages and radiocarbon ages was observed, implying that neither the relocated Japanese PSV data nor the global model accurately represent the Korean secular variation during the archeological period of this study. At present, archeomagnetic dating in Korea should be carefully applied in conjunction with other dating methods on the consideration of archeological context.
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Numerical Simulation of Droplet Jumping Process on Condensing Surface
Seungwon Shin,Youngsuk Nam 한국전산유체공학회 2014 한국전산유체공학회 학술대회논문집 Vol.2014 No.10
During the condensation on non-wetting surface, droplets formed on cooling wall can merge together then jump away from the surface. This behavior can increase heat and mass transfer significantly and recently draw quite attentions for potential performance enhancement in related engineering applications such as power generation, water harvesting, and thermal management. We tried to model complete jumping process of condensing droplet numerically. Level Contour Reconstruction Method was utilized with full parallelization. Multiphase flow simulation with phase change will be necessary ingredient along with accurate contact line dynamic handling. In this study, preliminary test results for droplet jumping process with phase change will be provided.
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Shin, Seungwon,Kim, Jinyoung,Yu, Ami,Seo, Hyung-Sik,Shin, Mi-Ran,Cho, Jae-Heung,Yi, Gilhee,Hong, Seung-Ug,Lee, Euiju Hindawi 2017 Evidence-based Complementary and Alternative Medic Vol.2017 No.-
<P>This study protocol aims to explore the effectiveness, safety, and cost-effectiveness of a herbal medication,<I> Gongjindan</I> (GJD), in patients with chronic dizziness. This will be a prospective, multicenter, randomized, double-blind, placebo-controlled, parallel-group, clinical trial. Seventy-eight patients diagnosed with Meniere's disease, psychogenic dizziness, or dizziness of unknown cause will be randomized and allocated to either a GJD or a placebo group in a 1 : 1 ratio. Participants will be orally given 3.75 g GJD or placebo in pill form once a day for 56 days. The primary outcome measure will be the Dizziness Handicap Inventory score. Secondary outcome measures will be as follows: severity (mean vertigo scale and visual analogue scale) and frequency of dizziness, balance function (Berg Balance Scale), fatigue (Fatigue Severity Scale) and deficiency pattern/syndrome (qi blood yin yang-deficiency questionnaire) levels, and depression (Korean version of Beck's Depression Inventory) and anxiety (State-Trait Anxiety Inventory) levels. To assess safety, adverse events, including laboratory test results, will be monitored. Further, the incremental cost-effectiveness ratio will be calculated based on quality-adjusted life years (from the EuroQoL five dimensions' questionnaire) and medical expenses. Data will be statistically analyzed at a significance level of 0.05 (two-sided). This trial is registered with ClinicalTrials.gov NCT03219515, in July 2017.</P>
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Shin, Seungwon,Juric, Damir John Wiley Sons, Ltd. 2009 International journal for numerical methods in flu Vol.60 No.7
<P>Successful interface methods for multiphase flows need to be designed to operate well in the opposite extremes of strongly surface tension-dominant flows on the one hand and strongly deforming flows on the other. To this end, recent advances in direct numerical simulation of multiphase flows have involved the hybridization of popular methods. One hybrid approach developed by the authors is the level contour reconstruction method (LCRM), which combines the characteristics of both the front tracking and the level set method. It was designed specifically for general 3D multiphase flow problems where very dynamic and deformable interfaces interact and where accuracy, reliability, and simplicity are essential features. In this paper, we carry the hybridization of the LCRM with the level set technique to a further level in that the explicit calculation of a distance function is introduced and plays a crucial role in the interface reconstruction procedure as well as in the calculation of the surface tension force. An accurate method of computing the distance function directly from the tracked interface is presented whereby a vector distance function is found, i.e. the minimum distance to the interface as well as the corresponding minimum distance point location on the interface itself. This information allows us to calculate a compact curvature field for the computation of the surface tension force, which decreases the level of parasitic currents to a negligible level. Various benchmark test cases to demonstrate the accuracy of the new schemes compared with other existing methods are provided. Copyright © 2008 John Wiley & Sons, Ltd.</P>
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Seungwon Shin,박수정,황민우 한국한의학연구원 2021 Integrative Medicine Research Vol.10 No.2
Background: Sipjeondaebo-tang (SJDBT, Shi-quan-da-bu-tang in Chinese) is a widely prescribed herbal medicine in traditional Korean medicine. This study aimed to evaluate the effectiveness and safety of SJDBT for treating chronic fatigue syndrome (CFS). Methods: Ninety-six eligible participants were randomly allocated to either the SJDBT or placebo groups in a 1:1 ratio. Nine grams of SJDBT or placebo granules were administered to the patients for 8 weeks. The primary outcome was the response rate, defined as the proportion of participants with a score of 76 or higher in the Checklist Individual Strength assessment. Other measurements for fatigue severity, quality of life, and qi/blood/yin/yang deficiency were included. Safety was assessed throughout the trial. Results: At week 8, the response rate did not significantly differ between the groups (SJDBT: 35.4%; placebo: 54.2%; P = 0.101, effect size [95% confidence interval] = 0.021 [-0.177, 0.218]). However, the scores of the visual analogue scale (P = 0.001, -0.327 [-0.506, -0.128]), Fatigue Severity Scale (P = 0.020, 0.480 [0.066, 0.889]), and Chalder fatigue scale (P = 0.004, -0.292 [-0.479, -0.101]) for the SJDBT group showed significant improvements in fatigue severity at the endpoint. Quality of life was not significantly different. Furthermore, SJDBT significantly ameliorated the severity of qi deficiency compared to that in the placebo group. No serious adverse events were observed. Conclusion: This trial failed to show a significant improvement in fatigue severity, as assessed by the CIS-deprived response rate. It merely showed that SJDBT could alleviate the severity of fatigue and qi deficiency in patients with CFS. However, the further study is needed to confirm the details.
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Diagnosis and treatment principle in <i>Sasang</i> medicine: original symptom
Shin, Seungwon,Kim, Yun-Hee,Hwang, Min-Woo Elsevier Science B.V., Amsterdam 2016 Integrative medicine research Vol.7 No.4
<P>The purpose of this review was to demonstrate the definition of the original symptom (OS) and how it works in medical procedures as to the <I>Sasang</I> medicine based on the Jema Lee's <I>Donguisusebowon</I> (<I>Longevity and Life Preservation in Eastern Medicine</I>). OS is defined as the sum of all clinical information featured by an individual's intrinsic characteristics as <I>Sasangin</I> and health state prior to onset. It is the key factor in the clinical application of <I>Sasang</I> medicine including the diagnosis of constitutional type and <I>Sasang</I> symptomatology because the imbalance of metabolic functions of each <I>Sasangin</I> originates from that. The working principles of the OS and <I>Sasang</I> symptomatology can be summarized as follows. First, clinical information regarding cold or heat intolerance determines the cold or heat pattern of <I>Sasang</I> symptomatology. Another is the present worsening of the severity of <I>Sasang</I> symptomatology by one level as compared with that in the past. Symptoms prior to the onset worsen to a higher level of severity after any disorder breaks out. Finally, the treatment strategy and progress of each <I>Sasangin</I> are determined following the characteristics of the OS. Theoretical and clinical studies should be conducted to show the specific criteria for the diagnosis of <I>Sasang</I> symptomatology in the future.</P>
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