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RISS 인기검색어
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- 저자 : Sethna, P. (검색결과 4 건)
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Zheng, Fei,Zhang, Ming,Ding, Qi,Sethna, Ferzin,Yan, Lily,Moon, Changjong,Yang, Miyoung,Wang, Hongbing Cold Spring Harbor Laboratory Press 2016 Learning & Memory Vol.23 No.8
<P>Mental health and cognitive functions are influenced by both genetic and environmental factors. Although having active lifestyle with physical exercise improves learning and memory, how it interacts with the specific key molecular regulators of synaptic plasticity is largely unknown. Here, we examined the effects of voluntary running on long-term potentiation (LTP) and memory formation in mice lacking type 1 adenylyl cyclase (AC1), a neurospecific synaptic enzyme that contributes to Ca2+-stimulated cAMP production. Following 1 mo of voluntary running-wheel exercise, the impaired LTP and object recognition memory in AC1 knockout (KO) mice were significantly attenuated. Running up-regulated exon II mRNA level of BDNF (brain-derived neurotrophic factor), though it failed to increase exon I and IV mRNAs in the hippocampus of AC1 KO mice. Intrahippocampal infusion of recombinant BDNF was sufficient to rescue LTP and object recognition memory defects in AC1 KO mice. Therefore, voluntary running and exogenous BDNF application overcome the defective Ca2+-stimulated cAMP signaling. Our results also demonstrate that alteration in Ca2+-stimulated cAMP can affect the molecular outcome of physical exercise.</P>
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Outcomes Associated with Nasal Reconstruction Post-Rhinectomy: A Narrative Review
John Jithin,Gupta Rohun,Grossbauer Anne,Chung Michael,Sethna Anita,Abboud Michel,Cox Eric,Hart Justin,Folbe Adam,Chaiyasate Kongkrit 대한성형외과학회 2022 Archives of Plastic Surgery Vol.49 No.1
The face and the external nose define an individual's physical appearance. Nasal deformities can cause facial disfigurement along with unwanted psychological repercussions. Nasal deformities range in severity, with the most severe cases being indications for a rhinectomy, due to the complexity of the nasal defect. According to published literature, there is no consensus among otolaryngologists and plastic surgeons on which technique or flap use is preferred in terms of complications, aesthetic outcome, or patient satisfaction. The goal of this study is to provide a comprehensive analysis of published studies on nasal reconstruction following rhinectomy. Using the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols guidelines for writing systematic reviews, a systematic review was conducted. Four databases were searched using a search strategy. These articles were then imported into the COVIDENCE software and went screening and thorough article review. After screening 2,237 articles, 23 studies were then extracted for data collection analysis. We collected data from 12 case series, 4 case studies, 1 prospective case series, and 4 retrospective chart review studies. The most commonly reported flaps were forehead flaps, superior extended nasal myocutaneous island, forearm free flaps, anterolateral thigh (ALT) free flap, medial femoral condyle free flap (n = 8), and zygomaticus implants (n = 6), and retained nasal prosthesis. Although not specifically indicated by a certain number, the most common indication for the rhinectomy was malignancy, followed by traumas, postsurgical complications, radionecrosis, and congenital nasal malformations.Although several donor flaps can be used after rhinectomy, we conclude that there is no preference over what flap has superior patient outcomes after analysis. As of current, there are no prospective studies that exist. Therefore, more research is necessary to determine the results of each flap.
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Outcomes Associated with Nasal Reconstruction Post-Rhinectomy: A Narrative Review
John Jithin,Gupta Rohun,Grossbauer Anne,Chung Michael,Sethna Anita,Abboud Michel,Cox Eric,Hart Justin,Folbe Adam,Chaiyasate Kongkrit 대한성형외과학회 2022 Archives of Plastic Surgery Vol.49 No.2
The face and the external nose define an individual's physical appearance. Nasal deformities can cause facial disfigurement along with unwanted psychological repercussions. Nasal deformities range in severity, with the most severe cases being indications for a rhinectomy, due to the complexity of the nasal defect. According to published literature, there is no consensus among otolaryngologists and plastic surgeons on which technique or flap use is preferred in terms of complications, aesthetic outcome, or patient satisfaction. The goal of this study is to provide a comprehensive analysis of published studies on nasal reconstruction following rhinectomy. Using the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols guidelines for writing systematic reviews, a systematic review was conducted. Four databases were searched using a search strategy. These articles were then imported into the COVIDENCE software and went screening and thorough article review. After screening 2,237 articles, 23 studies were then extracted for data collection analysis. We collected data from 12 case series, 4 case studies, 1 prospective case series, and 4 retrospective chart review studies. The most commonly reported flaps were forehead flaps, superior extended nasal myocutaneous island, forearm free flaps, anterolateral thigh (ALT) free flap, medial femoral condyle free flap (n = 8), and zygomaticus implants (n = 6), and retained nasal prosthesis. Although not specifically indicated by a certain number, the most common indication for the rhinectomy was malignancy, followed by traumas, postsurgical complications, radionecrosis, and congenital nasal malformations.Although several donor flaps can be used after rhinectomy, we conclude that there is no preference over what flap has superior patient outcomes after analysis. As of current, there are no prospective studies that exist. Therefore, more research is necessary to determine the results of each flap.
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A Minimum-Complexity 0.35㎛ Surface-Channel CMOS Process for Digital Logic and Analog Applications
Demirlioglu, E.,Yoon, E.,Pierce, J.,Blair, C.,Moverly, L.,Geha, S.,Wei, J.,Ciari, R.,Chen, K.,Kuo, C. S.,Sadjadi, R.,Brown, K.,Sethna, P.,Bariya, A.,Rocchetta, S. Della 대한전자공학회 1993 ICVC : International Conference on VLSI and CAD Vol.3 No.1
This paper presents a minimum-complexity 0.35 ㎛ CMOS technology with high performance and law mask count. Scaled LOCOS isolation and implantation through the field oxide allow a simplified process flow and provide adequate isolation at minimum active pacing. This architecture produces a retrograde well structure without requiring a MeV-energy implant. Surface channel PMOS and NMOS transistors with double diffused drains and silicide give high drive currents of 0.23 and 0.47mA/㎛, respectively, and low off-state leakage below 10pA/㎛ at drain voltage of 3.3 V.
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