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Jaganathan Anitha,Rajendran Selvakumar,Senthilnayagam Hema,Kadarkarai Murugan,타탄프렘쿠마르 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.105 No.-
Zinc oxide nanoparticles (ZnO NPs) were prepared by a facile, one-pot, greener approach using aqueousleaf extract of the medicinal plant Nuna (Morinda tinctoria) and were analyzed by ultraviolet–visible (UV–Vis) and Fourier-transform infrared (FT-IR) spectroscopy, powder X-ray diffraction (PXRD), field emissionscanning electron microscopy (FESEM), and transmission electron microscopy (TEM) techniques. TheTEM images confirmed that the as-prepared greener Nuna (Nu)-mediated ZnO NPs (Nu-ZnO NPs) werespherical in shape, with an average diameter of 8–10 nm. Further, the single phase and crystallinity ofthe Nu-ZnO NPs were observed by PXRD pattern. In addition, the biogenic Nu-ZnO NPs showed high cytotoxicityin human breast adenocarcinoma (MCF-7) cells in vitro. These tiny spherical bodies producedprofound toxicity according to the MTT assay, with IC50 of 46 mg/mL. Apoptosis and morphologicalchanges were studied using acridine orange/ethidium bromide and 40,6-diamidino-2-phenylindole fluorescencestaining and MTT assays. Finally, the anticancer efficacy of biosynthesized Nu-ZnO NPs wasimparted by dysregulation of cell division through arrest of growth-promoting and inhibiting signalsin the S phase, with further reduction in the G2/M phase of the cell cycle. In conclusion, Nu-ZnO NPs conferredMCF-7 cell toxicity by modulating proliferation and inducing apoptosis.