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RISS 인기검색어
- 검색키워드
- 저자 : Safai, P.D. (검색결과 13 건)
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Ganglioside as a Therapy Target in Various Types of Cancer
Qamsari, Elmira Safaie,Nourazarian, Alireza,Bagheri, Salman,Motallebnezhad, Morteza Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.4
Since their discovery in 1940, it has been well established that gangliosides are associated with a number of biological pathways and cellular processes such as growth, differentiation and toxin uptake. Gangliosides are glycosphingolipids containing neuraminic acid which are expressed on the plasma membrane of cells particularly in the nervous system. Heterogeneity and structural variation in the carbohydrate chains of gangliosides contributes to unique features of each of these molecules. Thirty five years ago it was discovered that aberrant glycosylation occurs in a variety of human cancers, including aberrant glycosylation of gangliosides. Ganglioside expression in terms of quality and quantity varies in different cancers and different roles may be played. Gangliosides, by affecting the immune system, including esxpression of cytokines and adhesion molecules, may inhibit anti-tumor mechanisms, as well as having direct impact on angiogenesis, cell movement and metastasis. It should be noted that different kinds of gangliosides do not all act by the same mechanisms.
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Diversity of Macrophomina phaseolina Based on Morphological and Genotypic Characteristics in Iran
Mahdizadeh, Valiollah,Safaie, Naser,Goltapeh, Ebrahim Mohammadi The Korean Society of Plant Pathology 2011 Plant Pathology Journal Vol.27 No.2
Fifty two Macrophomina phaseolina isolates were recovered from 24 host plant species through the 14 Iranian provinces. All isolates were confirmed to species using species-specific primers. The colony characteristics of each isolate were recorded, including chlorate phenotype, relative growth rate at $30^{\circ}C$ and $37^{\circ}C$, average size of microsclerotia, and time to microsclerotia formation. The feathery colony phenotype was the most common (63.7%) on the chlorate selective medium and represented the chlorate sensitive phenotype of the Iranian Macrophomina phaseolina population. Meantime, inter simple sequence repeats (ISSR) Markers were used to assess the genetic diversity of the fungus. Unweighted pair-group method using arithmetic means (UPGMA) clustering of data showed that isolates did not clearly differentiate to the specific group according to the host or geographical origins, however, usually the isolates from the same host or the same geographic origin tend to group nearly. Our results did not show a correlation between the genetic diversity based on the ISSR and phenotypic characteristics. Similar to the M. phaseolina populations in the other countries, the Iranian isolates were highly diverse based on the phenotypic and the genotypic characteristics investigated and needs more studies using neutral molecular tools to get a deeper insight into this complex species.
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Sorahinobar Mona,Safaie Naser,Moradi Babak 한국식물학회 2022 Journal of Plant Biology Vol.65 No.5
Priming of seeds is a simple and low-cost method in agriculture that improves plant growth, crop yield, and manages pathogens. The current study was carried out to determine SA seed priming effect on susceptibility and resistance of two wheat cultivars (Falat and Sumai3) to Fusarium graminearum at the seedling stage. Both the 1 and 2 mM SA-primed seeds showed a higher level of resistance against F. graminearum, as a lower disease incidence of 53% and 63% in the Falat and 48% and 76% in the Sumai3 was observed compared to the F. graminearum-inoculated water-primed control. Along with the increased resistance induced by SA priming, we observed increased activities of superoxide dismutase (SOD), polyphenol oxidase (PPO), peroxidases (POX) and phenylalanine ammonia lyase (PAL), in addition to higher mRNA accumulation of PAL, β-1,3-glucanase (GLU-2), chitinase (CHI), cytochrome P450 (CYP), and pleiotropic drug resistance (PDR) genes compared to the water-primed F. graminearum-inoculated control. Therefore, SA seed priming is a suitable alternative to manage the incidence of F. graminearum infection by triggering plant defense responses.
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Diversity of Macrophomina phaseolina Based on Morphological and Genotypic Characteristics in Iran
Valiollah Mahdizadeh,Naser Safaie,Ebrahim Mohammadi Goltapeh 한국식물병리학회 2011 Plant Pathology Journal Vol.27 No.2
Fifty two Macrophomina phaseolina isolates were recovered from 24 host plant species through the 14Iranian provinces. All isolates were confirmed to species using species-specific primers. The colony characteristics of each isolate were recorded, including chlorate phenotype, relative growth rate at 30°C and 37°C, average size of microsclerotia, and time to microsclerotia formation. The feathery colony phenotype was the most common (63.7%) on the chlorate selective medium and represented the chlorate sensitive phenotype of the Iranian Macrophomina phaseolina population. Meantime,inter simple sequence repeats (ISSR) Markers were used to assess the genetic diversity of the fungus. Unweighted pair-group method using arithmetic means (UPGMA) clustering of data showed that isolates did not clearly differentiate to the specific group according to the host or geographical origins, however, usually the isolates from the same host or the same geographic origin tend to group nearly. Our results did not show a correlation between the genetic diversity based on the ISSR and phenotypic characteristics. Similar to the M. phaseolina populations in the other countries, the Iranian isolates were highly diverse based on the phenotypic and the genotypic characteristics investigated and needs more studies using neutral molecular tools to get a deeper insight into this complex species.
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Safi, Yaser,Kadkhodazadeh, Mahdi,Safai, Pooria,Esmaeelinejad, Mohammad,Shamloo, Nafiseh Korean Academy of Periodontology 2014 Journal of Periodontal & Implant Science Vol.44 No.5
Purpose: This study aimed to assess the interdental bone level in premolar bitewing radiographs while retracting the cheeks. Methods: Seventy-two horizontal bone defects were created on dried mandibles and maxillae. The distance from the bone level to the cement-enamel junction of premolars was detected by a modified digital caliper (considered the gold standard). The reliability of all radiographs was assessed by intraclass correlation coefficient (ICC), and the validity was compared to the gold standard using the analysis of variance test. P-values less than 0.05 were considered statistically significant. Results: This study showed that the reliability of radiographs without a cheek simulator and with 0.16 second exposure time was significantly higher than that of the two other groups (ICC=0.96 compared to 0.93 and 0.88, respectively). The results from the radiographs without a cheek simulator and with 0.16 second exposure time were more similar to the gold standard measures than those of the two other groups, although the difference was not statistically significant. Conclusions: Retracting the buccal soft tissue plays an important role in increasing the accuracy of radiographs in detecting the interdental alveolar bone level and produces more accurate results than increasing the exposure time, although it does not have a significant role in reliability of results.
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Shayanfar, Nasrin,Bahari, Leila,Safaie-Naraghi, Zahra,Kamyab, Kambiz,Gheytanchi, Elmira,Rezaei, Nima Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2
Background: This study was performed to evaluate the amplification of HER-2/neu in patients with melanoma. Materials and Methods: Amplification of HER-2/neu was evaluated in a group of patients with melanoma, referred to two referral centers in Tehran, using immunohistochemistry (IHC) and chromogenic in situ hybridization (CISH) techniques. Results: Forty patients with mean age $57.9{\pm}19.5years$ were enrolled in this study. The most frequent type of melanoma was acral, while lower limbs were the most frequent sites. The amplification of HER2/neu was negative in 97.5% of patients with IHC and in 100% of patients with CISH technique. Only one case (2.5%) shows weak positive staining (+2) in IHC method. Fifty five percent of melanoma was ulcerative, and the most common stages of tumors were stages 4b and 3b. More than 47% of cases were in Clark level III, while the mean of Breslow thickness was $3.56{\pm}2.87mm$. The stage of the case that showed weakly positive staining (2+) in IHC was 4b. Conclusions: The amplification of HER2/neu biomarker was negative in patients with melanoma, using both CISH and IHC techniques.
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Ali Pourjavadi,Niloofar Safaie,Seyed Hassan Hosseini,Craig Bennett 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.38 No.-
A multi-layered catalyst based on poly(imidazole/imidazolium) and graphene oxide, with high loadingcapacity for immobilization of palladium nanoparticles was prepared. The catalyst was proven to behighly efficient for reduction of nitroarenes and also for Heck reaction with the use of only 0.1 mol% ofthe catalyst. The reduction of nitroarenes and Heck reaction were performed in water medium andexcellent yields of products were achieved. The synthesized catalyst was readily recovered and reusedfor up to 10 subsequent runs without significant loss of activity.
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Sotoodehnia, Mehran,Farmahini-Farahani, Mozhgan,Safaie, Arash,Rasooli, Fatemeh,Baratloo, Alireza The Korean Pain Society 2019 The Korean Journal of Pain Vol.32 No.2
Background: This study was conducted to compare the effectiveness of low-dose ketamine versus ketorolac in pain control in patients with acute renal colic presenting to the emergency department (ED). Methods: This is a double-blind randomized clinical trial. The initial pain severity was assessed using the numerical rating scale (NRS). Then, ketamine or ketorolac was administered intravenously at a dose of 0.6 mg/kg and 30 mg respectively. The pain severity and adverse drug reactions were recorded 5, 15, 30, 60, and 120 min thereafter. Results: The data of 62 subjects in the ketamine group and 64 patients in the ketorolac group were analyzed. The mean age of the patients was $34.2{\pm}9.9$ and $37.9{\pm}10.6\;years$ in the ketamine and ketorolac group, respectively. There was no significant difference in the mean NRS scores at each time point, except for the 5 min, between the two groups. Despite a marked decrease in pain severity in the ketamine group from drug administration at the 5 min, a slight increase in pain was observed from the 5 min to the 15 min. The rate of adverse drug reactions, including dizziness (P = 0.001), agitation (P = 0.002), increased systolic blood pressure (> 140 mmHg), and diastolic blood pressure (> 90 mmHg) was higher in the ketamine group. Conclusions: Low dose ketamine is as effective as ketorolac in pain management in patients with renal colic presenting to the ED. However, it is associated with a higher rate of adverse drug reactions.
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Increased lignan biosynthesis in the suspension cultures of Linum album by fungal extracts
Bahabadi, Sedigheh Esmaeilzadeh,Sharifi, Mozafar,Safaie, Naser,Murata, Jun,Yamagaki, Tohru,Satake, Honoo The Korean Society of Plant Biotechnology 2011 Plant biotechnology reports Vol.5 No.4
Linum album accumulates anti-tumor podophyllotoxin (PTOX) and its related lignans, which were originally isolated from an endangered species Podophyllum. In the present study, we examined the effects of five fungal extracts on the production of lignans in L. album cell cultures. Fusarium graminearum extract induced the highest increase of PTOX [$143{\mu}g\;g^{-1}$ dry weight (DW) of the L. album cell culture], while Rhizopus stolonifer extract enhanced the accumulation of lariciresinol up to $364{\mu}g\;g^{-1}$ DW, instead of PTOX. Typical elicitors, such as chitin, chitosan, or methyl jasmonate (MeJA), were shown to be less effective in lignan production in L. album cell cultures. These results verified the advantages of fungal extracts to increase lignan production in L. album cell culture, and suggested potential on-demand metabolic engineering of lignan biosynthesis using differential fungal extracts.
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Panicker, A.S.,Pandithurai, G.,Safai, P.D.,Dipu, S.,Lee, Dong-In Elsevier 2010 Atmospheric environment Vol.44 No.25
<P><B>Abstract</B></P><P>This paper discusses the extent of Black Carbon (BC) radiative forcing in the total aerosol atmospheric radiative forcing over Pune, an urban site in India. Collocated measurements of aerosol optical properties, chemical composition and BC were carried out for a period of six months (during October 2004 to May 2005) over the site. Observed aerosol chemical composition in terms of water soluble, insoluble and BC components were used in Optical Properties of Aerosols and Clouds (OPAC) to derive aerosol optical properties of composite aerosols. The BC fraction alone was used in OPAC to derive optical properties of BC aerosols. The aerosol optical properties for composite and BC aerosols were separately used in SBDART model to derive direct aerosol radiative forcing due to composite and BC aerosols. The atmospheric radiative forcing for composite aerosols were found to be +35.5, +32.9 and +47.6Wm<SUP>−2</SUP> during post-monsoon, winter and pre-monsoon seasons, respectively. The average BC mass fraction found to be 4.83, 6.33 and 4μgm<SUP>−3</SUP> during the above seasons contributing around 2.2 to 5.8% to the total aerosol load. The atmospheric radiative forcing estimated due to BC aerosols was +18.8, +23.4 and +17.2Wm<SUP>−2</SUP>, respectively during the above seasons. The study suggests that even though BC contributes only 2.2–6% to the total aerosol load; it is contributing an average of around 55% to the total lower atmospheric aerosol forcing due to strong radiative absorption, and thus enhancing greenhouse warming.</P>
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