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RISS 인기검색어
- 검색키워드
- 저자 : Saeedeh Farajzadeh (검색결과 3 건)
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Epidemiology and Clinical Features of Atopic Dermatitis in Kerman, a Desert Area of Iran
( Saeedeh Farajzadeh ),( Iraj Esfandiarpour ),( Maryam Sedaghatmanesh ),( Mahdieh Saviz ) 대한피부과학회 2014 Annals of Dermatology Vol.26 No.1
Background: Epidemiologic studies of atopic dermatitis (AD) in desert areas are still lacking. Objective: The aim of this study was to investigate the epidemiology of AD in children in Kerman city, a desert area in Iran. Methods: We evaluated preschool children (age, 2 to 7 years) and primary school students (age, greater than 7 up to 12 years) in Kerman. We selected 865 students to estimate the prevalence and assess other features of AD such as distribution of lesions, personal history, family history of atopy, aggravating factors, associated symptoms, and morphological variants. Results: The prevalence of AD was 9.1% in our study population. The prevalence of AD was 9.17% and 9.09% in males and females, respectively. The prevalence of AD in the age range of 2 to 7 years was 13.53% and 8.33% among children aged greater than 7 up to 12 years. In total, 82.27% of the patients were in chronic stage of the disease, and 31.6% had a personal history of other atopic diseases. At least one first-degree family member with atopy was seen in 46.83% of the patients. The most common sites of involvement were the head and neck. The most involved areas in the limbs were extensor surfaces. The most frequent morphological variant of AD was the common type. Conclusion: The prevalence of AD in Kerman was higher than in other Iranian cities but lower than that in developed countries. Diversity in the clinical features of AD has been observed among different studies, and the diagnostic criteria of AD should be adapted in proportion to the studied area. (Ann Dermatol 26(1) 26∼ 34, 2014)
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Maryam Hakimi Parizi,Saeedeh Farajzadeh,Iraj Sharifi,Abbas Pardakhty,Mohammad Hossein Daie Parizi,Hamid Sharifi,Ehsan Salarkia,Saeid Hassanzadeh 대한기생충학ㆍ열대의학회 2019 The Korean Journal of Parasitology Vol.57 No.4
In this study, we carried out extensive in vitro studies on various concentrations of tioxolone along with ben- zoxonium chloride and their niosomal forms against Leishmania tropica. Niosomes were prepared by the hydration meth- od and were evaluated for morphology, size, release study, and encapsulation efficiency. This study measured leishmani- cidal activity against promastigote and amastigote, apoptosis and gene expression levels of free solution and niosomal- encapsulated tioxolone along with benzoxonium chloride. Span/Tween 60 niosome had good physical stability and high encapsulation efficiency (more than 97%). The release profile of the entrapped compound showed that a gradual release rate. The combination of niosomal forms on promastigote and amastigote were more effective than glucantime. Also, the niosomal form of this compound was significantly less toxic than glucantime (P ≤ 0.05). The flowcytometric analysis on niosomal form of drugs showed that higher number of early apoptotic event as the principal mode of action (89.13% in 200 μg/mL). Also, the niosomal compound increased the expression level of IL-12 and metacaspase genes and de- creased the expression level of the IL-10 gene, which further confirming the immunomodulatory role as the mechanism of action. We observed the synergistic effects of these 2 drugs that induced the apoptotic pathways and also up regulation of an immunomodulatory role against as the main mode of action. Also, niosomal form of this combination was safe and demonstrated strong anti-leishmaniasis effects highlights further therapeutic approaches against anthroponotic cutane- ous leishmaniasis in future planning.
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A Novel Niosomal Combination of Selenium Coupled with Glucantime against Leishmania tropica
Mahshid Mostafavi,Payam Khazaeli,Iraj Sharifi,Saeedeh Farajzadeh,Hamid Sharifi,Alireza Keyhani,Maryam Hakimi Parizi,Sina Kakooei 대한기생충학ㆍ열대의학회 2019 The Korean Journal of Parasitology Vol.57 No.1
There is no effective treatment modality available against different forms of leishmaniasis. Therefore, the aim of this study was to improve the penetration and efficacy of selenium and glucantime coupled with niosomes and compared them with their simple forms alone on in vitro susceptibility assays. In this study, the niosomal formulations of selenium and in combination with glucantime were prepared. The size and morphology of the niosomal formulations were charac- terized and the effectivity of the new formulation was also evaluated using in vitro MTT assay, intra-macrophage model, and gene expression profile. From the results obtained, no cytotoxicity effect was observed for niosomal and simple forms of drugs, as alone or in combination. Niosomal formulations of the drugs significantly showed more inhibitory ef- fects (P ≤ 0.001) than the simple drugs when the selectivity index was considered. The gene expression levels of Interleu- kin (IL-10) significantly decreased, while the level of IL-12 and metacaspase significantly increased (P ≤ 0.001). The results of the present study showed that selenium plus glucantime niosome possess a potent anti-leishmanial effect and en- hanced their lethal activity as evidenced by the in vitro experiments.
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