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Mo, J.-H.,Kang, E.-K.,Quan, S.-H.,Rhee, C.-S.,Lee, C. H.,Kim, D.-Y. Wiley (Blackwell Publishing) 2011 Allergy Vol.66 No.2
<P>To cite this article: Mo J-H, Kang E-K, Quan S-H, Rhee C-S, Lee CH, Kim D-Y. Anti-tumor necrosis factor-alpha treatment reduces allergic responses in an allergic rhinitis mouse model. Allergy 2011; 66: 279-286. ABSTRACT: Background:??Tumor necrosis factor (TNF)-관 is a principal mediator of the acute inflammatory response, including allergic rhinitis. TNF-관 inhibitors are widely used for the treatment of inflammatory conditions such as rheumatoid arthritis and inflammatory bowel diseases; however, the effects of TNF-관 inhibitors on allergic rhinitis are not well established. We aimed to investigate the effects of infliximab, a TNF-관 inhibitor, on allergic rhinitis in a mouse model. Methods:??BALB/c mice were sensitized with ovalbumin (OVA) and alum, and challenged intranasally with OVA. The TNF-관 inhibitor, infliximab was administered intraperitoneally, and multiple parameters of allergic responses were evaluated to determine the effects of infliximab. Results:??Infliximab reduced allergic symptoms and eosinophilic infiltration into the nasal mucosa. It also suppressed total and OVA-specific IgE levels, and inhibited local Th2 cytokine transcription in the nasal mucosa and systemic Th2 cytokine production by splenocytes. Furthermore, the expression of E-selectin, neither intercellular adhesion molecule 1 (ICAM-1) nor vascular cell adhesion molecule 1 (VCAM-1), in the nasal mucosa was suppressed in the infliximab-treated group when compared to the nontreated group. Conclusion:??This study shows that the TNF-관 inhibitor infliximab induces anti-allergic effects by decreasing local and systemic Th2 cytokine (IL-4) production, total and OVA-specific IgE levels, adhesion molecule (E-selectin) expression, and eosinophil infiltration into the nasal mucosa in an allergic rhinitis model. Therefore, infliximab should be considered as a potential agent in treating allergic rhinitis.</P>
Chlorpyrifos-induced biomarkers in Japanese medaka (Oryzias latipes)
Jeon, H. J.,Lee, Y. H.,Mo, H. h.,Kim, M. J.,Al-Wabel, M. I.,Kim, Y.,Cho, K.,Kim, T. W.,Ok, Y. S.,Lee, S. E. Springer 2016 Environmental Science and Pollution Research Vol. No.
<P>Chlorpyrifos (CHL) is an organophosphate compound that is widely used as an insecticide. Due to its repeated use and high environmental residual property, CHL is frequently passed into aquatic environments by runoff. Consequently, there may be an adverse effect on aquatic vertebrate animals, including fish. Therefore, in this study, we assessed how CHL affected Japanese medaka (Oryzias latipes). The acute toxicity of CHL in adult fish after 96 h of exposure was determined to be 212.50, 266.79, and 412.28 mu g L-1 (LC25, LC50, and LC95, respectively). Acetylcholinesterase (AChE), glutathione S-transferase (GST), and carboxylesterase (CE) activities were obtained from the livers of dead or surviving fish, and the results showed 4.8-fold lower, 4.5-fold higher, and 18.6-fold lower activities for the AChE, GST, and CE, respectively, for 64-h exposure at a concentration of 400 mu g L-1 of CHL. In the embryo toxicity test, curved spines were observed in embryos that were exposed to CHL for 48 h in a concentration-dependent manner. With identification of biomarkers for CHL in the fish, two protein peaks, 5550.86 and 5639.79 m/z, were found to be upregulated. These two proteins can be used as protein biomarkers for CHL contamination in aquatic systems. A phosphatidyl choline with an m/z ratio of 556.32 dramatically decreased after CHL exposure in the fish; thus, it may be considered as a lipid biomarker for CHL. It is assumed as the first report to identify a phospholipid biomarker using a lipidomics approach in fish toxicology. Taken together, these results demonstrated the adverse effects of CHL on Japanese medaka and reveal several candidate biomarkers that can be used as diagnostic tools for determining CHL.</P>
상세 화학반응 모델 및 RIF 모델을 이용한 디젤 분무의 자발화 과정 해석
김성구,손정락,김용모,유용욱 한국액체미립화학회 2000 한국액체미립화학회지 Vol.5 No.2
The interaction between chemistry and turbulence is treated by employing the Representative Interactive Flamelet (RIF) Model The detailed chemistry of 114 elementary steps and 49 chemical species is adopted for the n-heptane/air reaction. In order to account for the spatial inhomogeneity of the scalar dissipation rate, the mufti-RIF is used. The effect of the number of RIF on ignition delay is discussed in detail. Numerical results indicate that the present RIF approach successfully predicts the ignition delay time as well as the essential features of a spray auto-ignition process.
이보성,이창갑,홍원표,옹장우,모상영,홍봉식,김택기 충남대학교 공업교육연구소 1984 論文集 Vol.7 No.2
To cope with an international technical development competition and maintain the continuous economic growth of our country, the role of Chungnam National University, which is sited in the Daedeok Science Town, is training available brains who can perform innovation technology through the triple cooperation of Industry-Institute-University. For this, we have studied the tendency and cooperation system of technical development of developed countries, and prepared the list of available manpower and facilities in the Daedeok Science Town. Also we have investigated the present status of Daejeon Industry -Complex. As a result, for continuous scientific and technical development of our industries, it is recommended that the Science Park, which is similar to Cambridge Science Park, should be build up in the Daedeok Science Town and positively drived the cooperation works of Industry-Institue-University.
저온에서의 Fe(NH₄)(SO₄)₂·12H₂O 의 뫼스바우어 스펙트럼
홍치유,모연곤,정창섭 동국대학교 자연과학연구소 1985 자연과학연구 논문집 Vol.5 No.-
본 실험은 Fe(NH₄) (SO₄)₂ㆍ 12H₂O 의 Mossbaure parameter 의 온도의 존성을 조사한 것으로서 25K 에서 300K 까지의 저욘영역에서 isomer shift의 온도에 따른 변화를 조사하였다. 또한 Mazo와 Kirkwood가 제안한 Kinetic temperature를 이용하여 시료의 Debye 및 Einstein Temperature를 결정하였다. 결정된 Debye 및 Einstein Temperature 는 각각 282.2K, 203K 이었다. Mossbauer parameters of hydrated ferric ammonium sulfate (Fe(NH₄)(SO₄)2ㆍ12H₂O) have measured from 25K to room temperature. The isomer shift and the log recoilless fraction (logf) were not liner with absolute temperature, except at high temperature, because of quantized lattic level. We obtained the Debye and the Dinstein temperature by fitting the kinetic temperature proposed by Mazo and Kirkwool. The obtained Debye and Dinstein temperature were 282.2K. 203K, respectively.
Synthesis of pyrazine via chemoselective reduction of β-keto-α-oximino ester using baker's yeast
Mo, K.,Park, J.H.,Kang, S.B.,Kim, Y.,Lee, Y.S.,Lee, J.W.,Keum, G. Elsevier 2016 Journal of molecular catalysis Enzymatic Vol.123 No.-
<P>The synthesis of pyrazines by the baker's yeast-mediated reaction of beta-keto-alpha-oximino esters and amides is described. Baker's yeast reduced oximes selectively over ketones of beta-keto-alpha-oximino esters to give the corresponding beta-keto-alpha-amino ester intermediates, which underwent spontaneous dimerization followed by air-induced aromatization to yield pyrazines. The chemoselective reduction of beta-keto-alpha-oximino amides using baker's yeast also afforded the corresponding pyrazines. Interestingly, both hydroximes and alkoximes gave the pyrazines by the baker's yeast-mediated reduction via the corresponding amino ketones, the known precursors of pyrazines. The reaction was strongly dependent upon pH of reaction medium, and gave optimum yields at pH 5. These results demonstrate that pyrazines were synthesized efficiently and eco-friendly using a whole-cell biocatalytic system as an alternative to chemical reduction. (C) 2015 Elsevier B.V. All rights reserved.</P>
Characteristics of waterflood at low rate in low permeability sandstones based on the CT scanning
S.Y. Mo,Q. Lei,G. Lei,S.H. Gai,Z.K. Liu 한국자원공학회 2018 Geosystem engineering Vol.21 No.6
It is reported that the flooding rate in low permeability sandstones is low and the oil recovery is hard to increase after water breakthrough. Understanding characteristics of waterflood is hence important for the recovery improvement. In this work, flooding tests on low permeability sandstones were conducted. The corresponding flooding characteristics were investigated by means of CT scanning and Nuclear Magnetic Resonance. Effects of irreducible water and different rates were also discussed in detail. Experimental results reveal a piston-like displacement at a low rate in low permeability samples. The saturation profile is steep and almost vertical to the forward direction. The results at a low rate confirm that once water broke through, increasing the flooding rate or flooding time can hardly reduce the remaining oil inside the sample. It is probably due to the high pore-throat ratio proven by rate-controlled mercury. Results also confirm that the presence of initial water enhanced sweep efficiency substantially. On one hand, because water had previously occupied the small pores, the subsequent oil can only invade relatively large pores and became more movable. On the other hand, stable collars can not form due to the steep front, which may suppress the snap-off.