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Xianfeng Gong,M inwei Wang,Zhen Wu,S hin -ichi T ashiro,Satoshi Onodera,Takashi Ikejima 생화학분자생물학회 2004 Experimental and molecular medicine Vol.36 No.6
Pseudolaric acid B was isolated from Pseudolarix kaempferi Gordon (Pinaceae) and was evaluated for the anti-cancer effect in HeLa cells. We ob-served that pseudolaric acid B inhibited cel proliferation and induced apoptosis in a time- and dose-dependent manner. HeLa cels treated with pseudolaric acid B showed typical characteristics of apoptosis including the morphological changes and DNA fragmentation. JNK inhibitor, SP60125, markedly inhibited pseudolaric acid B-induced cel death. In addition, Bcl-2 expression was down-re-gulated while Bax protein level was up-regulated. Caspase-3 inhibitor, z-DEVD-fmk, partially blocked pseudolaric acid B-induced cel death, and the expression of two classical caspase substrates, PARP and ICAD, were both decreased in a time- pase activation.