RISS 검색 - 국내학술지논문

무료
기관 내 무료
유료

내보내기
내책장담기
한글로보기

정확도순

내림차순

내림차순

10개씩 출력

1
Attitudes of Communication Sciences and Disorders Students at Jordan University of Science and Technology toward Stuttering and People Who Stutter

Khalid G. Al-Shdifat,Mikhled Maayah,Robert Mayo,Kenneth St. Louis 한국언어청각임상학회 2018 Communication Sciences and Disorders Vol.23 No.4
- 원문보기
Objectives: The current study explored the attitudes of 1st, 2nd, 3rd, and 4th year students in Communication Sciences and Disorders (CSD) at Jordan University of Science and Technology (JUST) toward stuttering and people who stutter (PWS). Methods: All students in the CSD program from each year level at JUST were invited to participate in the current study. A translated Arabic version of the Public Opinion Survey of Human Attributes-Stuttering (POSHA-S), a standard instrument, was used to compare stuttering attitudes from the four classes and also to compare them to attitudes of similar students and the general population from different countries on the POSHA-S database. Results: Data collected from the CSD students at JUST did not reflect any significant change in students’ overall attitudes toward stuttering as they progressed from the 1st through the 4th year. However, they exhibited more positive attitudes than the public in Jordan. Compared to the POSHA-S database, Jordanian attitudes were somewhat less positive than most SLP students sampled in other regions. Conclusion: The current study revealed that students of CSD in Jordan hold less positive attitudes toward stuttering and PWS compared to people from other countries in the same region. Findings are discussed relevant to the literature on attitudes toward stuttering and PWS.
2
Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma

Ally, Adrian,Balasundaram, Miruna,Carlsen, Rebecca,Chuah, Eric,Clarke, Amanda,Dhalla, Noreen,Holt, Robert A.,Jones, Steven J.M.,Lee, Darlene,Ma, Yussanne,Marra, Marco A.,Mayo, Michael,Moore, Richard A Elsevier 2017 Cell Vol.169 No.7
- 원문보기
Summary Liver cancer has the second highest worldwide cancer mortality rate and has limited therapeutic options. We analyzed 363 hepatocellular carcinoma (HCC) cases by whole-exome sequencing and DNA copy number analyses, and we analyzed 196 HCC cases by DNA methylation, RNA, miRNA, and proteomic expression also. DNA sequencing and mutation analysis identified significantly mutated genes, including LZTR1, EEF1A1, SF3B1, and SMARCA4. Significant alterations by mutation or downregulation by hypermethylation in genes likely to result in HCC metabolic reprogramming (ALB, APOB, and CPS1) were observed. Integrative molecular HCC subtyping incorporating unsupervised clustering of five data platforms identified three subtypes, one of which was associated with poorer prognosis in three HCC cohorts. Integrated analyses enabled development of a p53 target gene expression signature correlating with poor survival. Potential therapeutic targets for which inhibitors exist include WNT signaling, MDM4, MET, VEGFA, MCL1, IDH1, TERT, and immune checkpoint proteins CTLA-4, PD-1, and PD-L1. Highlights <UL> <LI> Analysis of hepatocellular carcinomas integrates data of multiple genomic platforms </LI> <LI> Mutated genes reveal oncogenic processes altering hepatocyte energy balance </LI> <LI> Multiplex analyses suggest a key role for Sonic hedgehog signaling in HCC </LI> <LI> IDH mutations point to a HCC subgroup molecularly similar to cholangiocarcinoma </LI> </UL> Graphical Abstract [DISPLAY OMISSION]