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RISS 인기검색어
- 검색키워드
- 저자 : Reger, Roxanne L. (검색결과 3 건)
- 무료
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EVALUATION OF SORBITOL/ETHANOL PRODUCTION BY ZYMOMONAS MOBILIS
Chun, U.H.,Regers, P.L. 경희대학교 부설 식량자원개발연구소 1989 硏究論文集 Vol.10 No.-
Zymomonas mobilis를 이용한 sorbitol ethanol 생산에 관해서 회분배양과 쎄라믹(ceramic) 반투과성막을 사용한 세포의 재이용법에 의한 연속배양 실험을 하였다. 주로 ethanol을 생산하는 균주의 glucose/fructose oxidoreductase(NADP와 결합된) system을 이용하였으며 glucose와 fructose가 동량 첨가된 배지에서 pH6.2, 온도35°에서 효소의 최대환성도를 나타내었다. 세포 재이용 연속배양에서 10%(W/V)의 각각 glucose와 fructose로부터 40.9g/ℓ의 sorbitol과 71g/ℓ의 ethanol이 생산되었다. The production of sorbitol and ethanol by Zymomonas mobilis as been evaluated at various conditions in batch and continuous cell recycle systems using ceramic membrane module. The conversion is carried out by a glucose/fructose oxidoreductase (and bound co-factor NADP) of Z. mobilis. Specific values (qp. ethanol, qp. sorbitol) were found to be highest at 35℃, pH 6.2 with an equimolar mixture of glucose and fructose. With 10% (w/v) each of glucose and fructose, a product stream containing 40.9g/l sorbitol and 7lg/l of ethanol was obtained in cell recycle system.
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Synthesis and Photophysical Properties of Hexaphenylbenzene-Pyrrolo[3,2-b]pyrroles
Stę,ż,ycki, Rafał,Reger, David,Hoelzel, Helen,Jux, Norbert,Gryko, Daniel Georg 2018 Synlett Vol. No.
<P>Methods for the synthesis of pyrrolo[3,2-b]pyrroles containing hexaphenylbenzene moieties at the 2- and 5-positions or the 1- and 4-positions have been developed. It was shown that placing a hexaphenylbenzene moiety at the 2- and 5-positions requires a Diels-Alder reaction between an alkyne-substituted pyrrolopyrrole core and a 2,3,4,5-tetraphenylcyclopenta-2,4-dien-1-one. The resulting dyes show a strong blue fluorescence that was hypsochromically shifted by chlorination at the 3- and 6-positions. The overall conjugation between the hexaphenylbenzene moieties and the pyrrolopyrrole core is limited, as evident from their photophysical properties. The hexaphenylbenzene moieties attached to the pyrrolo[3,2-b]pyrrole core could not be transformed into hexa-peri-hexabenzocoronenes through intramolecular oxidative aromatic coupling.</P>
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Yun, Young In,Park, Se Yeon,Lee, Hyun Ju,Ko, Jung Hwa,Kim, Mee Kum,Wee, Won Ryang,Reger, Roxanne L.,Gregory, Carl A.,Choi, Hosoon,Fulcher, Samuel F.,Prockop, Darwin J.,Oh, Joo Youn Elsevier 2017 cytotherapy Vol.19 No.1
<P>Background aims. Mesenchymal stromal cells (MSCs) offer tremendous potential for therapeutic applications for inflammatory diseases. However, tissue-derived MSCs, such as bone marrow derived MSCs (BM-MSCs), have considerable donor variations and limited expandability. It was recently demonstrated that MSCs derived from induced pluripotent stem cells (iPSC-MSCs) have less pro-tumor potential and greater expandability of homogenous cell population. In this study, we investigated the anti-inflammatory effects and mechanism of iPSC-MSCs in a murine model of chemical and mechanical injury to the cornea and compared the effects with those of BM-MSCs. Methods. To create an injury, ethanol was applied to the corneal surface in mice, and the corneal epithelium was removed with a blade. Immediately after injury, mice received an intravenous injection of (i) iPSC-MSCs, (ii) BM-MSCs or (iii) vehicle. Clinical, histological and molecular assays were performed in the cornea to evaluate inflammation. Results. We found that corneal opacity was significantly reduced by iPSC-MSCs or BM-MSCs. Histological examination revealed that the swelling and inflammatory infiltration in the cornea were markedly decreased in mice treated with iPSC-MSCs or BM-MSCs. Corneal levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta and IL-6 were lower in iPSC-MSC- and BM-MSC-treated mice, compared with vehicle-treated controls. In contrast, iPSC-MSCs with a knockdown of the TNF-alpha stimulating gene (TSG)-6 did not suppress the levels of inflammatory cytokines and failed to reduce corneal opacity. Conclusions. Together these data demonstrate that iPSC-MSCs exert therapeutic effects in the cornea by reducing inflammation in part through the expression of TSG-6, and the effects are similar to those seen with BM-MSCs.</P>
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