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Mechanical irritation by protruding bone: A possible cause of breast implant rupture
Aitzetmuller, Matthias Michael,Haslhofer, David Johannes,Wenny, Raphael,Schmidt, Manfred,Duscher, Dominik,Huemer, Georg Michael Korean Society of Plastic and Reconstructive Surge 2018 Archives of Plastic Surgery Vol.45 No.5
Although breast implants have been in clinical use for almost 6 decades and have undergone considerable development during this time, implant rupture is still a dreaded long-term complication. Some obvious external factors, such as trauma, can lead to implant rupture, but many studies have reported a high rate of "spontaneous" implant rupture. Herein, we present two cases with the aim of raising awareness of a new possible cause of "spontaneous" implant rupture: mechanical irritation by bony protrusions.
Mechanical irritation by protruding bone: A possible cause of breast implant rupture
Matthias Michael Aitzetmüller,David Johannes Haslhofer,Raphael Wenny,Manfred Schmidt,Dominik Duscher,Georg Michael Huemer 대한성형외과학회 2018 Archives of Plastic Surgery Vol.45 No.5
Although breast implants have been in clinical use for almost 6 decades and have undergone considerable development during this time, implant rupture is still a dreaded long-term complication. Some obvious external factors, such as trauma, can lead to implant rupture, but many studies have reported a high rate of “spontaneous” implant rupture. Herein, we present two cases with the aim of raising awareness of a new possible cause of “spontaneous” implant rupture: mechanical irritation by bony protrusions.
Preneet Cheema Brar,Elena Dingle,Daniela Ovadia,Sarah Pivo,Veeramac Prasad,Raphael David 대한소아내분비학회 2018 Annals of Pediatirc Endocrinology & Metabolism Vol.23 No.4
Purpose: Premature adrenarche (PA) often leads to polycystic ovary syndrome (PCOS). Higher anti-mullerian hormone (AMH) levels are reported in PCOS. We studied the androgen profile and AMH profiles in Hispanic girls with PA (aged 5–8 years) and age and body mass index (BMI) matched controls. Methods: Retrospective review of electronic medical records of girls who met the inclusion criteria for premature adrenarche were done. Results: PA girls (n=76) were matched to control girls (n=12) for age (mean±standard deviation) (6.7±1 years vs. 6.2±1.3 years) and BMI (20±10 kg/m2 vs. 17.8±2.7 kg/ m2). Dehydroepiandrostenedione sulfate (63.3±51.3 µg/dL vs. 29.8±17.3 µg/dL, P<0.001) and testosterone levels (11.4±4.8 ng/dL vs. 8.2±2.9 ng/dL, P=0.001) were significantly higher in the PA group than controls. AMH values (<14 years: reference range, 0.49–3.15 ng/mL) were 3.2±2.2 ng/mL vs. 4.6± 3.2 ng/mL respectively in the PA and control groups and were not different (P=0.4). AMH did not show a correlation with bone age (P=0.1), and testosterone (P=0.9) in the PA group. 17-hydroxyprogesterone levels (17-OHP ng/dL) were 39.5±30.5 ng/dL vs. 36.8±19.8 ng/dL in PA versus control girls. The concentration of 17-OHP was not statistically different between the control and PA groups. Conclusion: Higher AMH was not observed in PA girls and no correlation with BA and androgen levels was observed.
Weikert Thomas,Rapaka Saikiran,Grbic Sasa,Re Thomas,Chaganti Shikha,Winkel David J.,Anastasopoulos Constantin,Niemann Tilo,Wiggli Benedikt J.,Bremerich Jens,Twerenbold Raphael,Sommer Gregor,Comaniciu 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.6
Objective: To extract pulmonary and cardiovascular metrics from chest CTs of patients with coronavirus disease 2019 (COVID-19) using a fully automated deep learning-based approach and assess their potential to predict patient management. Materials and Methods: All initial chest CTs of patients who tested positive for severe acute respiratory syndrome coronavirus 2 at our emergency department between March 25 and April 25, 2020, were identified (n = 120). Three patient management groups were defined: group 1 (outpatient), group 2 (general ward), and group 3 (intensive care unit [ICU]). Multiple pulmonary and cardiovascular metrics were extracted from the chest CT images using deep learning. Additionally, six laboratory findings indicating inflammation and cellular damage were considered. Differences in CT metrics, laboratory findings, and demographics between the patient management groups were assessed. The potential of these parameters to predict patients’ needs for intensive care (yes/no) was analyzed using logistic regression and receiver operating characteristic curves. Internal and external validity were assessed using 109 independent chest CT scans. Results: While demographic parameters alone (sex and age) were not sufficient to predict ICU management status, both CT metrics alone (including both pulmonary and cardiovascular metrics; area under the curve [AUC] = 0.88; 95% confidence interval [CI] = 0.79–0.97) and laboratory findings alone (C-reactive protein, lactate dehydrogenase, white blood cell count, and albumin; AUC = 0.86; 95% CI = 0.77–0.94) were good classifiers. Excellent performance was achieved by a combination of demographic parameters, CT metrics, and laboratory findings (AUC = 0.91; 95% CI = 0.85–0.98). Application of a model that combined both pulmonary CT metrics and demographic parameters on a dataset from another hospital indicated its external validity (AUC = 0.77; 95% CI = 0.66–0.88). Conclusion: Chest CT of patients with COVID-19 contains valuable information that can be accessed using automated image analysis. These metrics are useful for the prediction of patient management.
Isolation and NMR Assignment of a Pennogenin Glycoside from Dioscorea bulbifera L. var sativa
Remy Bertrand Teponno,Azefack Leon Tapondjou,Jules Desire Djoukeng,Eliane Abou-Mansour,Raphael Tabacci,Pierre Tane,David Lontsi,Hee-Juhn Park 한국생약학회 2006 Natural Product Sciences Vol.12 No.1
steroidal saponin, 3-O-α-L-rhamnopyranosyl-(1. 2)-[α-L-rhamnopyranosyl-(1. 3)]-β-D-glucop-yranosylpennogenin (1, spiroconazole A) was isolated from the tubers of Dioscorea bulbifera L. var sativa and1H-and 13C-NMR assignment was completed using HMBC corelation. In addition, four phenolic substances, 2,7-dihydroxy-4-methoxyphenanthrene (2), quercetin (3), quercetin-3-O-β-D-glucopyranoside (4), and quercetin-3-O-β-D-galactopyranoside (5) were also isolated. KeywordsDioscorea bulbifera L. var sativa, steroidal saponin, phenanthrene, flavonoid, HMBC
Rael, Leonard T.,Thomas, Gregory W.,Craun, Michael L.,Curtis, C. Gerald,Bar-Or, Raphael,Bar-Or, David 한국생화학분자생물학회 (구 한국생화학회) 2004 BMB Reports Vol.37 No.6
Saturated fatty acids are less vulnerable to lipid peroxidation than their unsaturated counterparts. In this investigation, individual fatty acids of the C_(16), C_(18) and C_(20) families were subjected to the thiobarbituric (TBA) assay. These fatty acids were chosen based on their degree of saturation and configuration of double bonds. Interestingly, an assay threshold was reached where increasing the fatty acid concentration resulted in no additional decrease in the TBARS concentrations. Therefore, the linear range of TBARS inhibition was determined for fatty acids in the C_(16) and C_(20) families. The rate of TBARS inhibition was greater for the saturated than for unsaturated fatty acids, as measured from the slope of the linear range. These findings demonstrate the need to standardize the TBARS assay using multiple fatty acid concentrations when using this assay for measuring in vitro lipid peroxidation.
Rael, Leonard T.,Thomas, Gregory W.,Craun, Michael L.,Curtis, C. Gerald,Bar-Or, Raphael,Bar-Or, David Korean Society for Biochemistry and Molecular Biol 2004 Journal of biochemistry and molecular biology Vol.37 No.6
Saturated fatty acids are less vulnerable to lipid peroxidation than their unsaturated counterparts. In this investigation, individual fatty acids of the $C_{16}$, $C_{18}$ and $C_{20}$ families were subjected to the thiobarbituric (TBA) assay. These fatty acids were chosen based on their degree of saturation and configuration of double bonds. Interestingly, an assay threshold was reached where increasing the fatty acid concentration resulted in no additional decrease in the TBARS concentrations. Therefore, the linear range of TBARS inhibition was determined for fatty acids in the $C_{16}$ and $C_{20}$ families. The rate of TBARS inhibition was greater for the saturated than for unsaturated fatty acids, as measured from the slope of the linear range. These findings demonstrate the need to standardize the TBARS assay using multiple fatty acid concentrations when using this assay for measuring in vitro lipid peroxidation.