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- 저자 : Rajesh Khadgawat (검색결과 1 건)
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68Ga‑DOTANOC PET/CT for Screening and Surveillance of Von Hippel‑Lindau (VHL) disease
Shamim Ahmed Shamim,Geetanjali Arora,Naresh Kumar,Jhangir Hussain,Shreya Datta Gupta,Arun Raj ST,Kritin Shankar,Alpesh Goyal,Rajesh Khadgawat,Sambit Sagar,Chandrasekhar Bal 대한핵의학회 2023 핵의학 분자영상 Vol.57 No.5
Purpose Hereditary tumor syndrome Von Hippel-Lindau (VHL) disease is characterized by various benign and malignanttumors that are known to express somatostatin receptors (SSTR). We evaluated the role of 68Ga-DOTANOC PET/CT scan inpatients with positive germline mutation of the VHL gene, presented initially or on follow-up, for the detection of recurrentor synchronous/metachronous lesions. Methods Fourteen patients (8 males; 6 females) with mean age 30 ± 9.86 years were retrospectively analyzed, were testedpositive for VHL on gene dosage analysis, and underwent 68 Ga-DOTANOC PET/CT scan for disease evaluation. The numberand site of lesions were determined. The tracer uptake was analyzed semi-quantitatively by calculating the maximumstandardized uptake values (SUVmax) of lesion. Results Four of the 14 patients underwent scan for initial diagnosis as baseline, 6 patients for post-therapy disease status,and 4 patients for initial diagnosis as well as follow-up evaluation of the disease. A total of 67 lesions were detected in 14patients. The sites of lesions were cerebellar/vertebral/spinal (17; mean SUVmax = 7.85); pancreatic neuroendocrine tumor(NET) (11; mean SUVmax = 20.64); retina (3; mean SUVmax = 10.46); pheochromocytoma (10; mean SUVmax = 16.32);paragangliomas (3; mean SUVmax = 10.65); pancreatic cyst (9; mean SUVmax = 2.54); and renal cyst (8; mean SUVmax= 1.56) and miscellaneous lesions constituted 6 lesions. Conclusion Our results show that 68 Ga-DOTANOC PET/CT may be a useful modality for screening and follow-up of associatedtumors in patients with germline gene mutation for VHL. It can be used as a one-stop imaging modality for VHL patientsand may substitute for separate radiological investigations, making it more convenient for patients in terms of time and cost.
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