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RISS 인기검색어
- 검색키워드
- 저자 : Rajagopalan Rukkumani (검색결과 3 건)
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Venugopal P. Menon,Rajagopalan Rukkumani,Penumathsa Suresh Varma,Kode Aruna 한국식품영양과학회 2005 Journal of medicinal food Vol.8 No.2
The matrix metalloproteinases (MMPs) are a family of secreted and membrane-bound zinc endopeptidases.Collectively, these enzymes can degrade all of the components of the extracellular matrix including collagen, fibronectin,laminin, and basement membrane glycoproteins. Regulation in expression and activation of proteinases is one of the most im-portant mechanisms in organ morphogenesis. Fibrosis is a dynamic pathological process with a net accumulation of extra-cellular matrix proteins. In the present communication, we have investigated the changes that occur in the activity of liverMMPs in normal and in pathological conditions. The activity of MMPs was increased in thermally oxidized sunflower oil-and alcohol-treated groups, whereas the activity was decreased in the thermally oxidized oil. alcohol-fed group when com-pared with the normal control group. The activity was positively modulated when dendrodoine analogue [4-amino-5-benzoyl-2(4-methoxyphenylamino)thiazole] was administered along with ethanol and thermally oxidized oil, which indicates the pro-tective effect of this drug.
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Venugopal P. Menon,Kode Aruna,Penumathsa Suresh Varma,Kallikat Narayanan Rajasekaran,Rajagopalan Rukkumani 한국식품영양과학회 2005 Journal of medicinal food Vol.8 No.2
Excessive alcohol intake induces hyperlipidemia. Studies suggest that natural principles and their analogs are known to possess anti-hyperlipidemic properties. In the present work we tested the effect of curcumin, an active principle of turmeric (Curcuma longa), and a curcumin analog on alcohol- and thermally oxidized polyunsaturated fatty acid (PUFA)- induced hyperlipidemia. Male albino Wistar rats were used for the experimental study. Anti-hyperlipidemic activity of curcumin and curcumin analog was evaluated by analyzing the levels of cholesterol, triglycerides (TGs), phospholipids (PLs), and free fatty acids (FFAs). The results showed that the levels of cholesterol, TGs, PLs, and FFAs were increased significantly in alcohol-, PUFA-, and alcohol PUFA-treated groups, which were brought down significantly on treatment with either of the curcuminoids. Curcumin analog treatment was found to be more effective than curcumin treatment. From the results obtained, we conclude that both curcumin and its analog effectively protect the system against alcohol- and PUFA-induced hyperlipidemia and are possible candidates for the treatment of hyperlipidemia.
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Hepatoprotective Role of Ferulic Acid: A Dose-Dependent Study
Venugopal Padmanabhan Menon,Kode Aruna,Penumathsa Suresh Varma,Rajagopalan Rukkumani 한국식품영양과학회 2004 Journal of medicinal food Vol.7 No.4
Alcohol use is contributing to an unprecedented decline in life expectancy. Damage to the liver after ethanoladministration is a well-known phenomenon. Free radical mechanisms have been proposed to play a part in ethanol-inducedliver toxicity. Ingestion of diets rich in polyunsaturated fatty acids (PUFAs) along with alcohol is known to result in enhancedliver damage. The present work is aimed at evaluating the protective role of ferulic acid, a naturally occurring plant compo-nent, on alcohol- and PUFA-induced liver toxicity. Three different doses of ferulic acid (10, 20, and 40 mg/kg of body weight)were administered to rats given alcohol, heated PUFA (.PUFA), and alcohol . . PUFA. Influence of ferulic acid on alco-hol- and PUFA-induced liver damage was evaluated by analyzing the activities of the liver marker enzymes alkaline phos-phatase, .-glutamyl transferase, alanine transaminase, and aspartate transaminase. The activities of these liver marker enzymeswere increased in the alcohol, .PUFA, and alcohol .. PUFA groups but were decreased significantly on treatment with fer-ulic acid. The low dose (10 mg/kg of body weight) was not effective, but both 20 mg and 40 mg/kg of body weight werefound to be effective. The 20 mg/kg of body weight dose was found to be more effective than 40 mg/kg of body weight (thehigh dose). The administration of ferulic acid to normal rats did not produce any harmful effects. Thus our results show thatferulic acid is an effective anti-hepatotoxic agent without side effects and may be a good candidate in the current search fora natural hepatoprotective agent.
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