http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
A Novel Niosomal Combination of Selenium Coupled with Glucantime against Leishmania tropica
Mahshid Mostafavi,Payam Khazaeli,Iraj Sharifi,Saeedeh Farajzadeh,Hamid Sharifi,Alireza Keyhani,Maryam Hakimi Parizi,Sina Kakooei 대한기생충학ㆍ열대의학회 2019 The Korean Journal of Parasitology Vol.57 No.1
There is no effective treatment modality available against different forms of leishmaniasis. Therefore, the aim of this study was to improve the penetration and efficacy of selenium and glucantime coupled with niosomes and compared them with their simple forms alone on in vitro susceptibility assays. In this study, the niosomal formulations of selenium and in combination with glucantime were prepared. The size and morphology of the niosomal formulations were charac- terized and the effectivity of the new formulation was also evaluated using in vitro MTT assay, intra-macrophage model, and gene expression profile. From the results obtained, no cytotoxicity effect was observed for niosomal and simple forms of drugs, as alone or in combination. Niosomal formulations of the drugs significantly showed more inhibitory ef- fects (P ≤ 0.001) than the simple drugs when the selectivity index was considered. The gene expression levels of Interleu- kin (IL-10) significantly decreased, while the level of IL-12 and metacaspase significantly increased (P ≤ 0.001). The results of the present study showed that selenium plus glucantime niosome possess a potent anti-leishmanial effect and en- hanced their lethal activity as evidenced by the in vitro experiments.