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- 저자 : Park Sunghee Estelle (검색결과 2 건)
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Park, Sunghee Estelle,Song, Kang-Il,Kim, Hyungmin,Chung, Seok,Youn, Inchan Elsevier 2018 Behavioural brain research Vol.344 No.-
<P><B>Abstract</B></P> <P>Recent studies have established methods for establishing a rodent model that mimics progressive stages of human Parkinson’s disease (PD), via injection of graded doses of 6-hydroxydopamine (6-OHDA) into regions within the nigrostriatal pathway. However, the electrophysiological characteristics of the subthalamic nucleus (STN) in this model have not been fully elucidated in this model. This study aimed to investigate changes in the neuronal activity of the STN in a graded mouse model of PD. Increasing doses of 6-OHDA were unilaterally injected into the medial forebrain bundle (MFB) to produce a hemi-parkinsonian mouse model, mimicking early, moderate, advanced, and severe stages of human PD. Mice treated with higher doses of 6-OHDA demonstrated significantly lower rates of use of the impaired (contralateral) forelimb during wall contact, relative to sham mice. The STN firing rate was significantly increased in groups with >75% dopaminergic cell loss in the substantia nigra pars compacta (SNc), whereas little increase was observed in groups with partial lesions of the SNc, relative to the sham group. In addition, firing patterns of the STN in groups treated with higher doses of 6-OHDA became more irregular and exhibited burst-like patterns of activity, with dominant slow wave oscillations in the frequency range of 0.3–2.5 Hz. Our results demonstrated a strong correlation between neuronal activities in the STN and dopamine depletion in the nigrostriatal pathway, which can be manipulated by variation of 6-OHDA doses.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Dopamine depletion in the nigrostriatal pathway is dependent on 6-OHDA dose. </LI> <LI> Firing rate in the STN increases with >75% dopaminergic cell loss in the SNc. </LI> <LI> Firing patterns in the STN become more irregular with increasing doses of 6-OHDA. </LI> <LI> Dominant slow wave oscillation in the STN occurs with high doses of 6-OHDA. </LI> </UL> </P>
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Organ-on-a-chip technology for nanoparticle research
Kang Shawn,Park Sunghee Estelle,Huh Dan Dongeun 나노기술연구협의회 2021 Nano Convergence Vol.8 No.20
The last two decades have witnessed explosive growth in the field of nanoengineering and nanomedicine. In particular, engineered nanoparticles have garnered great attention due to their potential to enable new capabilities such as controlled and targeted drug delivery for treatment of various diseases. With rapid progress in nanoparticle research, increasing efforts are being made to develop new technologies for in vitro modeling and analysis of the efficacy and safety of nanotherapeutics in human physiological systems. Organ-on-a-chip technology represents the most recent advance in this effort that provides a promising approach to address the limitations of conventional preclinical models. In this paper, we present a concise review of recent studies demonstrating how this emerging technology can be applied to in vitro studies of nanoparticles. The specific focus of this review is to examine the use of organ-on-a-chip models for toxicity and efficacy assessment of nanoparticles used in therapeutic applications. We also discuss challenges and future opportunities for implementing organ-on-a-chip technology for nanoparticle research.
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