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RISS 인기검색어
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- 저자 : Parisa Yazdi (검색결과 3 건)
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Forat-Yazdi, Mohammad,Gholi-Nataj, Mohsen,Neamatzadeh, Hossein,Nourbakhsh, Parisa,Shaker-Ardakani, Hossein Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8
Background: Non-synonymous polymorphisms in XRCC1 hase been shown to reduce effectiveness of DNA repair and be associated with risk of certain cancers. In this study we aimed to clarify any association between XRCC1 Arg399Gln and colorectal cancer (CRC) risk by performing a meta-analysis of published case-control studies. Materials and Methods: PubMed and Google Scholar were searched to explore the association between XRCC1 and CRC. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the association strength. Publication bias was assessed by Egger's and Begg's tests. Results: Up to January 2015, 35 case control studies involving 9,114 CRC cases and 13,948 controls were included in the present meta-analysis. The results showed that the Arg399Gln polymorphism only under an allele genetic model was associated with CRC risk (A vs. G: OR 0.128, 95% CI 0.119-0.138, p<0.001). Also, this meta-analysis suggested that the XRCC1 Arg399Gln polymorphism might associated with susceptibility to CRC in Asians (A vs G: OR 0.124, 95% CI 0.112-0.138, p<0.001) and Caucasian (A vs G: OR 0.132, 95% CI 0.119-0.146, p<0.001) only under an allele genetic model. Conclusions: This meta-analysis confirms the association between XRCC1 Arg399Gln polymorphism and CRC risk and suggests that the heterogeneity is not strongly modified by ethnicity and deviation from the Hardy-Weinberg equilibrium.
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Hartoonian, Christine,Sepehrizadeh, Zargham,Tabatabai Yazdi, Mojtaba,Jang, Yong Suk,Langroudi, Lida,Amir Kalvanagh, Parisa,Negahdari, Babak,Karami, Ali,Ebtekar, Massoumeh,Azadmanesh, Kayhan Kowsar 2014 Hepatitis monthly Vol.14 No.3
<P><B>Background:</B></P><P>Using molecular adjuvants offers an attractive strategy to augment DNA vaccine-mediated immune responses. Several studies have revealed that an efficient HCV vaccine model should be able to induce both humoral and cell mediated immune responses targeting the conserved regions of the virus to circumvent the immune escape mutants. The beta chemokine Macrophage Inflammatory Protein 3-beta (MIP-3beta) is a key modulator of dendritic cells (DCs) and T-cells interaction, functions during immune response induction and is secreted specifically by cells in the lymphoid tissues.</P><P><B>Objectives:</B></P><P>In the present study, we questioned whether co-administration of MIP-3beta gene could enhance the immune responses to HCV core in DNA vaccination.</P><P><B>Materials and Methods:</B></P><P>Expression and biological activity of MIP-3beta expressing plasmid were evaluated by ELISA and transwell migration assays, respectively. HCV core DNA vaccine ± plasmid expressing MIP-3beta were electroporated subcutaneously to the front foot pads of BALB/c mice on days 0 and 14, and HCV core protein booster was applied to all core-DNA-vaccine received mice on the day 28. Both cell mediated immunity (proliferation, IFN-γ and IL-4 cytokine release, IFN-γ ELISpot and cytotoxic Granzyme B release assays) and humoral immune responses (total IgG and IgG2a/IgG1 subtyping) were evaluated ten days after final immunization.</P><P><B>Results:</B></P><P>Mice covaccinated with MIP-3beta elicited an enhanced Th1 biased systemic immune response as evidenced by higher IFN-γ/IL-4 and anti-core IgG2a/IgG1 ratio, lymphoproliferation, strong cytolytic GrzB release and enhanced population of IFN-γ producing immunocytes. Likewise, the humoral immune response assumed as the total anti-core IgG level was augmented by MIP-3beta co-delivery.</P><P><B>Conclusions:</B></P><P>These results exhibited the immuno potentiator effects of MIP-3beta plasmid when coadministrated with the HCV core DNA vaccine. Complimentary studies integrating MIP-3beta as a genetic adjuvant in HCV-core-DNA vaccination models are warranted.</P>
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Zoya Tahergorabi,Fatemeh Salmani,Samira Hooshmand Jonaidabad,Bahere Behdani,Parisa Yazdi,Mahmoud Zardast,Mitra Moodi 대한산부인과학회 2019 Obstetrics & Gynecology Science Vol.62 No.6
PurposePolycystic ovary syndrome (PCOS) is a gynecological endocrine disorder that is characterized by disturbances in ovarianblood flow and angiogenesis. The aim of this study was to determine the association of vascular endothelial growthfactor (VEGF) and thrombospondin-1 (TSP-1) serum levels with the body mass index (BMI) in patients with PCOScompared with healthy subjects. MethodsThe study was conducted with 80 subjects in 3 PCOS groups, including normal weight, overweight, and obese PCOSgroups, and a control group of healthy subjects (n=20). The participants in all groups completed a questionnairecomprising sociodemographic and obstetric questions. The PCOS diagnosis in the study subjects was confirmed basedon the Rotterdam criteria, BMI was determined according to the World Health Organization guidelines, and the lipidaccumulation product index was calculated for all groups. Venous blood samples were collected from all participantsafter fasting to measure the serum levels of fasting blood glucose (FBG), lipids, insulin, VEGF, TSP-1, and leptin. ResultsOur findings showed that the serum VEGF level was significantly higher in the normal BMI PCOS group than thatin the control group (P=0.03), and the TSP-1 level was significantly lower in the obese PCOS group than that in thecontrol group (P=0.04). ConclusionsOur study demonstrated that alterations in VEGF and TSP-1 concentrations are dependent on BMI. Because abnormalovarian angiogenesis is considered to be the main feature of PCOS, the study of ovarian angiogenic imbalance isproposed as a new tool for PCOS diagnosis and management.
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