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김용백,Thomas P. Brown,Mary J. Pantin-Jackwood 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.3
In this study, we investigated the effects of T-cell suppression on the pathogenesis of subgroup J avian leukosis virus (ALV-J). Chickens were treated with cyclosporin A (CSP) 50 mg/Kg body weight or a corresponding volume of olive oil per every three days after hatching until the end of experiment. Some of the chickens from each treatment group were infected with an isolate of ALV-J, ADOL-7501, at 2 weeks of age. The effects of viral infection were compared to uninfected birds in same treatment group. Intramuscular injection of CSP induced significant T-cell specific immunosuppression determined by decreased cutaneous basophilic hypersensitivity response and decreased lymphocyte mitogenic activity using concanavalin A. Most of the chickens examined had Marek’s disease virus infection prior to 3 weeks of age. The percentage of antibody-positive birds and antibody titers were similar in infected chickens between both treatment groups. The ratio of viremic chickens was significantly higher in CSP treated group than that of the Oil treated group. Microscopically, one CSP treated chicken had a nephroblastoma at 10 weeks post infection. At 7 and 10 weeks post-infection, more chickens had myeloid cell infiltrations in multiple organs including heart, liver and occasionally lung. Expression of ALV-J viral antigen determined by immunohistochemical staining was significantly higher in CSP treated chickens than Oil treated chickens at 10 weeks post-infection. This study indicated that chemically-induced T-cell suppression may enhance pathogenicity of the AVL-J virus in broilers.
B?atrice Parguel,Karine Charry,Ga?lle Pantin Sohier,Fanny Thomas 글로벌지식마케팅경영학회 2023 Global Marketing Conference Vol.2023 No.07
Considering meat consumption's massive impact on climate change, environmental NGOs are increasingly campaigning to encourage consumers to reduce unsustainable meat consumption, i.e., to eat less and/or better meat. They usually use messages based on environmental appeals to do so. Yet, the effectiveness of such appeals in international campaigns may depend on countries as cultural beliefs influence food consumption behaviors. Therefore, in this research, we explore the effectiveness of such campaigns across 5 European countries, controlling for individual cultural orientations. Considering an environmental degradation appeal, we first show that countries have no influence on the campaign’s effectiveness, unlike specific individual cultural orientations, including masculinity and uncertainty avoidance. We replicate these results in the same 5 countries considering an alternative appeal, i.e., animal welfare. Recommendations to international NGOs managers result from these results.
Detection of Polarized Infrared Emission by Polycyclic Aromatic Hydrocarbons in the MWC 1080 Nebula
Zhang, Han,Telesco, Charles M.,Hoang, Thiem,Li, Aigen,Pantin, Eric,Wright, Christopher M.,Li, Dan,Barnes, Peter American Astronomical Society 2017 The Astrophysical journal Vol.844 No.1
<P>Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in astrophysical environments, as revealed by their pronounced emission features at 3.3, 6.2, 7.7, 8.6, 11.3, and 12.7 mu m commonly ascribed to the C-H and C-C vibrational modes. Although these features have long been predicted to be polarized, previous searches for PAH polarization led to null or, at best, tentative detections. Here we report the definite detection of polarized PAH emission at 11.3 mu m in the nebula associated with the Herbig Be star MWC 1080. We measure a polarization degree of 1.9% +/- 0.2%, which is unexpectedly high compared to models. This poses a challenge in the current understanding of the alignment of PAHs, which is required to polarize the PAH emission but thought to be substantially suppressed. PAH alignment with a magnetic field via a resonance paramagnetic relaxation process may account for such a high level of polarization.</P>
Yong-baek Kim,Thomas P. Brown,Mary J. Pantin-Jackwood 대한수의학회 2004 Journal of Veterinary Science Vol.5 No.1
Studies were performed to determine the effects of Bcell suppression on the pathogenesis of Subgroup J avian leukosis virus (ALV-J) in broiler chickens. Neonatal chickens were treated with cyclophosphamide (CY) or PBS, and then infected with ALV-J (ADOL-7501) at 2 weeks of age. CY treatment induced B cell specific immunosuppression throughout the experiment confirmed by decreased bursal weight, intact lymphocyte mitogenetic activity stimulated by Con A and increased relative subpopulation of CD3-positive cells as measured by flow cytometry. Chickens in this experiment had Mareks disease virus exposure prior to three weeks of age as determined by the presence of lymphocytic infiltration and antibody. Virus neutralizing antibody against ALV-J was first observed at 6 weeks post-infection in some of the infected chickens in the PBS group. As expected, none of the chickens from the CY group and uninfected chickens developed virus-neutralizing antibody. The viremic status was measured by real time RT-PCR using SYBR green I dye. The percentage of viremic chickens was significantly higher, and more chickens had high titered viremia, in the CY treated group. No neoplastic foci consistent with ALVJ infection were observed in any of the experimental chickens. The frequency and intensity of viral antigen expression determined by immunohistochemistry was significantly higher in tissues from CY treated birds than those of PBS treated chickens at 3 weeks post-infection. This study showed that B cell specific immunosuppression with CY treatment in chickens resulted in increase in viremia and viral antigen load in tissues.