비만증 환자에서 한약제에 의한 체중 감소효과

Oh, Seung-Joon,Jeong, In-Kyung,Kim, Young-Seol,Choi, Young-Kil,Paeng, Jeong-Ryung,Bae, Jung-Hwan,Shin, Hyun-Dae 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Seung-Joon Oh, In-Kyung Jeong, Young-Seol Kim, Young-Kil Choi, Jeong-Ryung Paeng¹, Jung-Hwan Bae and Hyun-Dae Shin²Department of internal Medicine, College Medicine, Endocrine Research Institute¹. Department of Rehabilitation, College of Oriental Medicine², Seoul, korea. Bady Fat Reduction Effects of Red Ginseng Compound Preparation on the Patients with Obesity. Proceedings of International Symposium on East-West Medicine, Seoul. 244-254, 1999.-Obesity can be defined as a metabolic disease due to an increased state of fat tissues caused by an imbalance of calorie intake and use. Recently, in Korea by improvement and westernization of food intake, along with decrease in exercise activities, the prevalence of obesity has increased greatly. Our objectives were to study stability and effects of decrease in body fat by administering red ginseng compound preparation (known to have body fat decreasing effects in laboratory animals) to obesity patients on low calorie diets. Changes in weight and body fat were measured while carrying out calorie-restricted diets on patients for 4 weeks, then administering red ginseng compound preparation for another 4 weeks. The patients were 20 people whose BMI were 25kg/㎡ or over and whose percent body fat was also 30% or over when tested by bioelectrical conductivity. 1. Changes in weight were from 70.04kg(base line) to 67.43kg(after taking red ginseng compound preparation). 2. In similar sense, BMI decreased from 27.12kg/㎡(base line) to 26.56kg/㎡(after dieting), and further to 26.01kg/㎡ (after taking red ginseng compound preparation). The BMI seemed to decrease significantly compared to the baseline after the use of red ginseng compound. 3. Waist hip ratio was changed from 0.8858(base line) to 0.8728, but it was statistically insignificant. 4. The percent body fat was 35,16%(base line), 33.87%(after dieting), and 31.68%(after taking red ginseng compound preparation). 5. Complete blood cell count and blood chemisrty remained unaffected by the administration. 6. In concern to endocrinologic studies, T3 decreased from 118.7 to 98.2ng/dL, and T4 increased from 8.8 to 9.2㎕/ dL. Epinephrine showed a tendency to decreased from 0.27 to 0.25 ng/mL, and norepinephrine increased from 0.39 to 0.44ng/mL. 7. Leptin was not changed. 8. Some patients complained adverse effects; constipation(5 patients, may be due to diet therapy), fatigue (2 patients), pruritus(2 patients), flushing(s patients), dizziness(3 patients) and epigastric discomfort(2 patients). However their symptoms were mild, so medication did not stopped. In conclusion, loss of weight without significant side effects was observed during low calorie diet and red ginseng compound preparation administration. This is thought to be in relation to sympathetic nerve system rather than adrenal gland. Also, further long0term studies should be required, since the observed results were based on short-term changes in weight.

Electrochemical Dechlorination of 1,2,4-Trichlorobenzene Using a Reticulated Vitreous Carbon Electrode

Paeng, Ki-Jung,Lim, Chae-Yun,Lee, Bo-Young,Myung, No-Seung,Rhee Paeng, In-Sook Korean Chemical Society 2003 Bulletin of the Korean Chemical Society Vol.24 No.9

Stepwise dechlorination of 1,2,4-trichlorobenzene was observed at a glassy carbon electrode in dimethylformamide containing 0.1 M tetraethylammonium perchlorate. Especially, dechlorination to dichlorobenzene and further to monochlorobenzene or benzene was successfully demonstrated with a porous reticulated vitreous carbon electrode. Electrochemical dechlorination of polychlorobenzenes employing a flow cell with a reticulated vitreous carbon working electrode is also described. Preliminary experiments with a flow cell showed that dechlorination of trichlorobenzene to dichlorobenzene was partially completed while dechlorination to benzene or monochlorobenzene was not successful, suggesting that a flow rate and electrolysis time should be further optimized for the complete electrolysis.

TOWARDS AN EFFECTIVE FIELD THEORY FOR COLD COMPRESSED BARYONIC MATTER

PAENG, WON-GI,RHO, MANNQUE World Scientific 2010 Modern Physics Letters A Vol.25 No.6

<P> This is an extended version of the note taken by the first author (W.-G.P.) on a lecture given by the second author (M.R.) as a first part of the series on 'Hadronic Matter Under Extreme Conditions,' the principal theme of the WCU-Hanyang Program. It covers the attempts to go in a framework anchored on effective field theory of QCD from zero density to the nuclear matter density and slightly beyond, with the ultimate goal of arriving at the density relevant to compact stars, including chiral phase transition and quark matter. The focus is on the conceptual aspects rather than detailed 'fitting' of the data on the kinds of physics that are being addressed to in radioactive-ion-beam machines in operation as well as in project (such as 'KoRIA' in Korea) and will be explored at such forthcoming accelerators as FAIR/GSI. The approach presented here is basically different from the standard ones found in the literature in that the notion of hidden local symmetry - which underlies the chiral symmetry of the strong interactions - and its generalization to dual gravity description involving infinite tower of hidden gauge fields are closely relied on. </P>

Alternative Medical Treatment for Radioiodine-Refractory Thyroid Cancers

Paeng, Jin-Chul,Kang, Keon-Wook,Park, Do-Joon,Oh, So-Won,Chung, June-Key The Korea Society of Nuclear Medicine 2011 핵의학 분자영상 Vol.45 No.4

Thyroid cancer is one of the most rapidly increasing cancers in many countries. Although most thyroid cancers are differentiated cancers and easily treated with radioiodine (RI), a portion of differentiated and undifferentiated cancers is refractory not only to RI therapy, but also to radiotherapy and chemotherapy. Thus, various alternative therapies have been tested in RI-refractory thyroid cancers. These alternative therapies include two major categories: redifferentiation therapy and recent molecular target therapy. Several clinical trials have investigated these therapies. They demonstrated potential effects of the therapies, although the results have been somewhat limited so far. Thus, the future strategy for undifferentiated thyroid cancers will involve individualized, lesion-specific, and combined therapy. In this review, the basic mechanism of each redifferentiation and molecular target therapy is discussed, and results of recent clinical trials using these therapeutic agents are summarized.

MANIFOLDS WITH NONNEGATIVE RICCI CURVATURE ALMOST EVERYWHERE

Paeng, Seong-Hun Korean Mathematical Society 1999 대한수학회지 Vol.36 No.1

Under the condition of RicM $\geq$ -(n-1), injM $\geq$ I0, we prove the existence of an $\varepsilon$>0 such that on the region of volume $\varepsilon$>0 the curvature condition of splitting theorem can be weakened.

The Goldreich-Goldwasser-Halevi cryptosystem using polynomial representations

Paeng, Seong-Hun 建國大學校基礎科學硏究所 2003 理學論集 Vol.28 No.-

A public key cryptosystem based on the closest vector problem was suggested by Goldreich, Goldwasser and Halevi [2]. We suggest an improvement of this system by suing polynomial representations.

Computation of the Mutual Radiation Impedance in the Acoustic Transducer Array: A Literature Survey

Paeng, Dong-Guk,Bok, Tae-Hoon,Lee, Jong-Kil The Acoustical Society of Korea 2009 韓國音響學會誌 Vol.28 No.e2

Mutual radiation impedance becomes more important in the design and analysis of acoustic transducers for higher power, better beam pattern, and wider bandwidth at low frequency sonar systems. This review paper focused on literature survey about the researches of mutual radiation impedance in the acoustic transducer arrays over 60 years. The papers of mutual radiation impedance were summarized in terms of transducer array structures on various baffle geometries such as planar, cylindrical, spherical, conformal, spheroidal, and elliptic cylindrical arrays. Then the computation schemes of solving conventional quadruple integral in the definition of mutual radiation impedance were surveyed including spatial convolution method, which reduces the quadruple integral to a double integral for efficient computation.

YCG063 inhibits Pseudomonas aeruginosa LPS-induced inflammation in human retinal pigment epithelial cells through the TLR2-mediated AKT/NF-κB pathway and ROS-independent pathways

PAENG, SUNG HWA,PARK, WON SUN,JUNG, WON-KYO,LEE, DAE-SUNG,KIM, GI-YOUNG,CHOI, YUNG HYUN,SEO, SU-KIL,JANG, WON HEE,CHOI, JUNG SIK,LEE, YOUNG-MIN,PARK, SAEGWANG,CHOI, IL-WHAN UNKNOWN 2015 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.36 No.3

<P>YCG063 is known as an inhibitor of reactive oxygen species?(ROS); however, its intracellular mechanisms of action remain poorly understood. In the present study, we investigated the effects of YCG063 on the inflammatory response of Pseudomonas aeruginosa lipopolysaccharide?(PA-LPS)?stimulated human retinal pigment epithelial cells?(RPE cells). Human adult RPE cells?(ARPE?19) were stimulated with PA-LPS. We then investigated the LPS-induced expression of several inflammatory mediators, such as interleukin?(IL)-6, IL-8, monocyte chemoattractant protein-1?(MCP-1) and intracellular adhesion molecule-1?(ICAM-1) in the ARPE-19 cells. We performed an enzyme-linked immunosorbent assay?(ELISA), western blot analysis, electrophoretic mobility shift assay?(EMSA) and fluorescence-activated cell sorting?(FACS) to elucidate the mechanisms involved in the anti-inflammatory effects of YCG063 in the PA-LPS-stimulated cells. The results revealed that treatment with YCG063 significantly inhibited the levels of IL-6, IL-8, MCP-1 and ICAM-1 in the PA-LPS-stimulated ARPE-19 cells. YCG063 also markedly inhibited the phosphorylation of AKT in the PA?LPS-stimulated cells. In addition, the activation of nuclear factor-κB?(NF-κB) was also attenuated folllowing treatment with YCG063. ROS were not generated in the PA-LPS-stimulated cells. In conclusion, our data indicate that YCG063 may prove to be a potential protective agent against inflammation, possibly through the downregulation of Toll?like receptor?2?(TLR2) and the AKT-dependent NF-κB activation pathway in PA-LPS-stimulated ARPE-19 cells. Furthermore, this anti-inflammatory activity occurred through ROS-independent signaling pathways.</P>

Ideal probe single-molecule experiments reveal the intrinsic dynamic heterogeneity of a supercooled liquid

Paeng, Keewook,Park, Heungman,Hoang, Dat Tien,Kaufman, Laura J. National Academy of Sciences 2015 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.112 No.16

<P><B>Significance</B></P><P>Supercooled liquids are believed to exhibit spatially heterogeneous dynamics, where molecular mobility within a given spatial region may differ from that of a neighboring region, potentially by orders of magnitude. If supercooled liquids are ergodic, such that the spatial average of all regions with distinct dynamics equals the time average of a given region, these regions of distinct dynamics must interchange over time. With an appropriate probe, similar in size and mobility to the host, single-molecule measurements can provide direct access to these spatial and temporal variations. Here, such a probe is used, revealing how relaxation dynamics are distributed in time and space and directly demonstrating ergodicity of a prototypical glass former down to the glass transition temperature.</P><P>The concept of dynamic heterogeneity and the picture of the supercooled liquid as a mosaic of environments with distinct dynamics that interchange in time have been invoked to explain the nonexponential relaxations measured in these systems. The spatial extent and temporal persistence of these regions of distinct dynamics have remained challenging to identify. Here, single-molecule fluorescence measurements using a probe similar in size and mobility to the host <I>o</I>-terphenyl unambiguously reveal exponential relaxations distributed in time and space and directly demonstrate ergodicity of the system down to the glass transition temperature. In the temperature range probed, at least 200 times the structural relaxation time of the host is required to recover ensemble-averaged relaxation at every spatial region in the system.</P>

Feasibility and kinetic characteristics of 68Ga-NOTA-RGD PET for in vivo atherosclerosis imaging

Paeng, J. C.,Lee, Y. S.,Lee, J. S.,Jeong, J. M.,Kim, K. B.,Chung, J. K.,Lee, D. S. Springer Science + Business Media 2013 Annals of nuclear medicine Vol.27 No.9