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RISS 인기검색어
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- 저자 : Oshi, Murtada A. (검색결과 5 건)
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Oshi, Murtada A.,Naeem, Muhammad,Bae, Junhwan,Kim, Jihyun,Lee, Juho,Hasan, Nurhasni,Kim, Wooseong,Im, Eunok,Jung, Yunjin,Yoo, Jin-Wook Elsevier 2018 Carbohydrate Polymers Vol.198 No.-
<P><B>Abstract</B></P> <P>Oral colon-targeted drug delivery has gained popularity as an effective strategy for treatment of inflammatory bowel disease (IBD). In this study, we prepared colon-targeted dexamethasone microcrystals (DXMCs) coated with multilayers of chitosan oligosaccharide (CH), alginate (AG), and finally Eudragit S 100 (ES) (ES<SUB>1</SUB>AG<SUB>4</SUB>CH<SUB>5</SUB>-DXMCs) using a layer-by-layer (LBL) coating technique. Particle size, surface charge, <I>in vitro</I> drug release, and <I>in vivo</I> anti-inflammatory activity of ES<SUB>1</SUB>AG<SUB>4</SUB>CH<SUB>5</SUB>-DXMCs were evaluated. ES<SUB>1</SUB>AG<SUB>4</SUB>CH<SUB>5</SUB>-DXMCs had an average particle size of 2.34 ± 0.19 μm and a negative surface charge of - 48 ± 9 mV. ES<SUB>1</SUB>AG<SUB>4</SUB>CH<SUB>5</SUB>-DXMCs demonstrated pH-dependent dexamethasone release, avoiding initial burst drug release in acidic pH conditions of the stomach and small intestine, and providing subsequent sustained drug release in the colonic pH. Importantly, ES<SUB>1</SUB>AG<SUB>4</SUB>CH<SUB>5</SUB>-DXMCs exhibited a significant therapeutic activity in a mouse model of colitis compared to other DXMCs. Overall, the LBL-coated DXMCs presented here could be a promising colon-targeted therapy for IBD.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Dexamethasone microcrystals with colon-targeted chitosan/alginate/Eudragit S multilayers were fabricated. </LI> <LI> Unwanted burst release of dexamethasone was prevented in the upper gastrointestinal tract pH. </LI> <LI> Dexamethasone was released in a sustained manner after reaching the colonic pH. </LI> <LI> Excellent therapeutic activity was found in a mouse model of colitis. </LI> </UL> </P>
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Yasuhiko Shimomura,Oshie Kotake,Hiroyuki Kaga,Noboru Masuda Korean Institute of Landscape Architecture 2004 Journal of the Korean institute of landscape archi Vol.2 No.-
This study aimed at providing suggestions in designing open space so that parks and bordering facilities are well related to each other in terms of the visual access and human activities. The design survey was conducted in the center of Osaka City, using parks there as the study material. The relation between parks and their bordering facilities was evaluated in terms of the visual access and human activities. Through the results of this study, as the design methods for improving relations between parks and their bordering facilities, unified design and creation of square in the boundary area between them, placing access paths to facilities in parks, and planting trees to create Vista, Screen, and Framework landscapes are of great importance.
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Naeem, Muhammad,Oshi, Murtada A.,Kim, Jihyun,Lee, Juho,Cao, Jiafu,Nurhasni, Hasan,Im, Eunok,Jung, Yunjin,Yoo, Jin-Wook Elsevier 2018 Nanomedicine Vol.14 No.3
<P><B>Abstract</B></P> <P>In this study, we developed pH-triggered surface charge-reversal lipid nanoparticles (LNPs), loaded with budesonide, which could precisely deliver the drug to inflamed colon segments for the treatment of ulcerative colitis. Polyethyleneimine (PEI) was used to render LNPs cationic (PEI-LNPs), and Eudragit® S100 (ES) was coated on PEI-LNPs to obtain pH-triggered charge-reversal LNPs (ES-PEI-LNPs). ES coating avoided a burst drug release under acidic conditions mimicking the stomach and early small intestine environments and showed a sustained release in the colon. The surface charge of ES-PEI-LNPs switched from negative to positive under colonic conditions owing to pH-triggered removal of the ES coating. Bioimaging of the mouse gastrointestinal tract and confocal analysis of colon tissues revealed that ES-PEI-LNPs selectively accumulated in an inflamed colon. Furthermore, ES-PEI-LNPs mitigated experimental colitis in mice. These results suggest that the pH-triggered charge-reversal LNPs could be a promising drug carrier for ulcerative colitis therapy and other colon-targeted treatments.</P> <P><B>Graphical Abstract</B></P> <P>In this study, we developed, through intelligent design, pH-triggered surface charge-reversal lipid nanoparticles, which were shown to precisely deliver a corticosteroid drug to inflamed colon segments in an ulcerative colitis mouse model. The results of the study suggest that the pH-triggered charge-reversal lipid nanoparticles are a promising drug nanocarrier for colon-targeted therapy, including ulcerative colitis treatments.</P> <P>[DISPLAY OMISSION]</P>
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Naeem, Muhammad,Bae, Junhwan,Oshi, Murtada A,Kim, Min-Soo,Moon, Hyung Ryong,Lee, Bok Luel,Im, Eunok,Jung, Yunjin,Yoo, Jin-Wook Dove Medical Press 2018 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.13 No.-
<P><B>Background</B></P><P>Colon-targeted oral nanoparticles (NPs) have emerged as an ideal, safe, and effective therapy for ulcerative colitis (UC) owing to their ability to selectively accumulate in inflamed colonic mucosa. Cyclosporine A (CSA), an immunosuppressive agent, has long been used as rescue therapy in severe steroid-refractory UC. In this study, we developed CSA-loaded dual-functional polymeric NPs composed of Eudragit<SUP>®</SUP> FS30D as a pH-sensitive polymer for targeted delivery to the inflamed colon, and poly(lactic-co-glycolic acid) (PLGA) as a sustained-release polymer.</P><P><B>Methods</B></P><P>CSA-loaded Eudragit FS30D nanoparticles (ENPs), PLGA nanoparticles (PNPs), and Eudragit FS30D/PLGA nanoparticles (E/PNPs) were prepared using the oil-in-water emulsion method. Scanning electron microscope images and zeta size data showed successful preparation of CSA-loaded NPs.</P><P><B>Results</B></P><P>PNPs exhibited a burst drug release of >60% at pH 1.2 (stomach pH) in 0.5 h, which can lead to unwanted systemic absorption and side effects. ENPs effectively inhibited the burst drug release at pH 1.2 and 6.8 (proximal small intestine pH); however, nearly 100% of the CSA in ENPs was released rapidly at pH 7.4 (ileum–colon pH) owing to complete NP dissolution. In contrast to single-functional PNPs and ENPs, the dual-functional E/PNPs minimized burst drug release (only 18%) at pH 1.2 and 6.8, and generated a sustained release at pH 7.4 thereafter. Importantly, in distribution studies in the gastrointestinal tracts of mice, E/PNPs significantly improved CSA distribution to the colon compared with PNPs or ENPs. In a mouse model of colitis, E/PNP treatment improved weight loss and colon length, and decreased rectal bleeding, spleen weight, histological scoring, myeloperoxidase activity, macrophage infiltration, and expression of proinflammatory cytokines compared with PNPs or ENPs.</P><P><B>Conclusion</B></P><P>Overall, this work confirms the benefits of CSA-loaded E/PNPs for efficiently delivering CSA to the colon, suggesting their potential for UC therapy.</P>
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