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- 저자 : Olaposi (검색결과 2 건)
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Kayode Komolafe,Tolulope Mary Olaleye,Olaposi Idowu Omotuyi,Aline Augusti Boligon,Margareth Linde Athayde,Akintunde Afolabi Akindahunsi,Joao Batista Teixeira da Rocha 사단법인약침학회 2014 Journal of Acupuncture & Meridian Studies Vol.7 No.4
Aqueous-methanolic extract of Parkia biglobosa bark (PBB) was screened for its polyphe- nolic constituents, in vitro antioxidant activity, and effect on mitochondria redox status. The in vitro antioxidant activity was assessed by using the scavenging abilities and the reducing powers of 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) and 2,2 0 -azino-bis(3- ethylbenzothiazoline-6-sulfonic acid) (ABTS) diammonium salt radical cation against Fe 3þ . Subsequently, the ability of PBB to inhibit lipid peroxidation induced by FeSO 4 (10 mm) and its metal-chelating potential were investigated. The effects of the extract on basal reactive oxygen species (ROS) generation and on the mitochondrial membrane potential (DJm) in isolated mitochondria were determined by using 2 0 , 7 0 -dichlorodihy- drofluorescin (DCFH) oxidation and safranin fluorescence, respectively. PBB mitigated the Fe(II)-induced lipid peroxidation in rat tissues and showed dose-dependent scav- enging of DPPH (IC 50 : 98.33 ± 10.0 mg/mL) and ABTS. (trolox equivalent antioxidant concentration, TEAC value = 0.05), with considerable ferric-reducing and moderate metal-chelating abilities. PBB caused slight decreases in both the liver and the brain mitochondria potentials and resulted in a significant decrease (p < 0.001) in DCFH oxida- tion. Screening for polyphenolics using high-performance liquid chromatography coupled to a diode array detector (HPLC-DAD) revealed the presence of caffeic acid, gallic acid, catechin, epigalocatechin, rutin, and quercetin. These results demonstrate for the first time the considerable in vitro antioxidant activity and favorable effect of PBB on mito- chondria redox status and provide justification for the use of the plant in ethnomedicine.
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Ayodeji J. Ajibare,Olabode O. Akintoye,Ademola C. Famurewa,Moshood A. Folawiyo,Olawande D. Bamisi,Abraham Olufemi Asuku,Oyedoyin Eunice Oyegbola,Christopher O. Akintayo,Babatunde A. Olofinbiyi,Olaposi 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.9
Polycystic ovarian syndrome (PCOS) is an endocrine disorder in women’s reproductive age. Currently, thepathophysiology of PCOS is unclear, and the limited treatment options are unsatisfactory. Virgin coconut oil (VCO) isfunctional food oil associated with pharmacological effects in reproductive disorders. Therefore, we aimed to evaluatewhether VCO could enhance clomiphene (CLO) therapy against PCOS in female rats. Rats were randomly divided: (1)Control, (2) PCOS model, (3) PCOS + CLO, (4) PCOS + VCO, and (5) PCOS + CLO + VCO. The PCOS was induced viadaily letrozole (1 mg/kg, orally) administration for 21 days. After the PCOS induction, CLO, VCO, and CLO + VCO wereadministered from days 22 to 36. Serum levels of gonadotropin-releasing hormone (GnRH), follicle-stimulating hormone(FSH), luteinizing hormone (LH), testosterone, estrogen, progesterone, and prolactin were estimated. Polymerase chainreaction gene expression for nuclear factor-erythroid-related factor 2, heme oxygenase-1 (HO-1), catalase (CAT), glutathionereductase (GSR), LH receptor (LHr), androgen receptor (AR), tumor necrosis factor-alpha (TNF-a), interleukin-1b (IL-1b),and caspase-3 were analyzed. The letrozole-induced PCOS caused considerable increases in GnRH, LH, prolactin, estrogen,and testosterone, whereas FSH decreased significantly compared to the control. The gene expression of Nrf2, HO-1, CAT, andGSR were markedly diminished, while IL-1b, TNF-a, caspase-3, AR, and LHr prominently increased compared to control. Interestingly, the CLO and VCO separately exerted anti-inflammatory and endocrine balance effects. However, VCOenhancedCLO effect in LH, prolactin and testosterone, Nrf2, HO-1, CAT, GSR, and AR. VCO may synergize with CLO todepress hyperandrogenism and oxidative inflammation in PCOS.
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