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Oh, Seunghan,Choi, Eun-Joo,Erkhembaatar, Munkhsoyol,Kim, Min Seuk Hindawi Limited 2015 Journal of nanomaterials Vol.2015 No.-
<P>Titanium (Ti) possesses excellent properties for use in dental implants but has low osteogenic surface properties that result in limiting rapid osseointegration. The physiological interaction between the surface of the implant material and bone cells, especially osteoclasts, is a crucial factor in determining successful osseointegration. However, the details of such an interaction remain elusive. Here, we demonstrated that nanotopography on the Ti surface is a crucial factor for modulating intracellular signal transduction in bone marrow-derived macrophages (BMMs). To define this, intracellular Ca<SUP>2+</SUP>and ROS were simultaneously measured in BMMs that were seeded on polished Ti and TiO2nanotubes. We found that UV photocatalysis of TiO2immediately elicits intracellular calcium concentration ([Ca<SUP>2+</SUP>]i) increase and intracellular reactive oxygen species concentration ([ROS]i) reduction in cells on TiO2nanotubes. UV photocatalysis-mediated [Ca<SUP>2+</SUP>]iincrease is dependent on extracellular and intracellular ROS generation. Furthermore, extracellular Ca<SUP>2+</SUP>influx through voltage-gated calcium channels (VGCCs) is critical for the UV photocatalysis-mediated [Ca<SUP>2+</SUP>]iincrease, while phospholipase C (PLC) activation is not required. Considering the physiological roles of Ca<SUP>2+</SUP>signaling in BMMs and osteoclastogenesis, nanotopography on the Ti surface should be considered an important factor that can influence successful dental implantation.</P>
오승한(Seunghan Oh) 대한치과의사협회 2013 대한치과의사협회지 Vol.51 No.1
Dental ceramics is well known to have excellent esthetics, biocompatibility as well as high compressive strength. However, the fragility of ceramics against tensile and shear loads leading to the delayed fracture of micro crack on ceramic surface and the backwardness of ceramic fabrication technique limit the usage of ceramic materials in dentistry. Among all ceramic materials, zirconia has been introduced to overcome the drawback of conventional dental ceramics in the field of dentistry due to the nature of zirconia featuring proper opalescence and high fracture toughness. Also, novel manufacturing techniques enable ceramic materials to prepare high esthetic anterior and posterior all ceramic system. In this paper, it is introduced and discussed that novel techniques characterizing the bond strength between zirconia core and veneering ceramics and analyzing the fluorescence of dental ceramics in order to overcome the gap between the results of basic research and the feasibility of the results in the field of dental clinics.
오승한(Seunghan Oh) 대한치과의사협회 2010 대한치과의사협회지 Vol.48 No.2
Tissue engineering has been enhanced by advance in biomaterial nature, surface structure and design. In this paper, I report specifically vertically aligned titania (TiO₂) nanotube surface structuring for optimization of titanium implants utilizing nanotechnology. The formation, mechanism, characteristics of titania nanotubes are explained and emerging critical role in tissue engineering and regenerative medicine is reviewed. The main focus of this paper is on the unique 3 dimensional tubular shaped nanostructure of titania and its effects on creating epochal impacts on cell behavior. Particularly, I discuss how different cells cultured on titania nanotube are adhered, proliferated, differentiated and showed phenotypic functionality compared to those cultured on flat titanium. As a matter of fact, the presence of titania nanotube surface structuring on titanium for dental applications had an important effect improving the proliferation and mineralization of osteoblasts in vitro, and enhancing the bone bonding strength with rabbit tibia over conventional titanium implants in vivo. The nano-features of titania nanotubular structure are expected to be advantageous in regulating many positive cell and tissue responses for various tissue engineering and regenerative medicine applications.