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O. Benavente-Garcia,J. Castillo,J. Lorente,M. Alcaraz 한국식품영양과학회 2002 Journal of medicinal food Vol.5 No.3
The radioprotective effects of a polyphenolic extract of Olea europaea L. leaves (OL); theflavonoids diosmin and rutin, which are widely used as pharmaceuticals; and the sulfur-con-taining compounds dimethylsulfoxide (DMSO) and 6-n-propyl-2-thiouracil (PTU) were de-termined by using the micronucleus test for anticlastogenic activity, evaluating the reductionof the frequency of micronucleated polychromatic erythrocytes (MnPCEs) in bone marrow ofmouse before and after X-ray irradiation. With treatment before X-irradiation, the most ef-fective compounds were, in order, rutin . DMSO . OL . PTU. diosmin. These resultsshowed, for the polyphenols studied, a linear correlation (r2 5 0.965) betwen anticlastogenicactivity and antioxidant capacity. The magnitude of protection with treatment after X-irradi-ation were lower, and the most effective compounds were, in order, OL . diosmin . rutin;DMSO and PTU lacked radioprotective activity. Therefore, OL is the only substance thatshowed a significant anticlastogenic activity both before and after X-ray irradiation treatments.Structurally, the fre oxygen radicals and lipoperoxyradicals scavenging capacity and, conse-quently, the anticlastogenic activity of these polyphenolic compounds are based principallyon the presence of specific functional groups, mainly catechol groups (rutin, oleuropein, hy-droxytyrosol, verbascoside, luteolin), that also increase the stability of the aroxyl-polyphenolradical generated in the above processes.125