http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Sung-Kyun Park,Xiaorong Zhou,Kathryn E. Pendleton,Olga V. Hunter,Jennifer J. Kohler,Kathryn A. O’Donnell,Nicholas K. Conrad 한국당과학회 2018 한국당과학회 학술대회 Vol.2018 No.01
Modification of nucleocytoplasmic proteins with O-GlcNAc regulates a wide variety of cellular processes and has been linked to human diseases. The enzymes O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA) add and remove O-GlcNAc, but the mechanisms regulating their expression remain unclear. Here, we demonstrate that retention of the fourth intron of OGT is regulated in response to O-GlcNAc levels. We further define a conserved intronic splicing silencer (ISS) that is necessary for OGT intron retention. Deletion of the ISS in colon cancer cells leads to increases in OGT, but O-GlcNAc homeostasis is maintained by concomitant increases in OGA protein. However, the ISS-deleted cells are hypersensitive to OGA inhibition in culture and in soft agar. Moreover, growth of xenograft tumors from ISS-deleted cells is compromised in mice treated with an OGA inhibitor. Thus, ISS-mediated regulation of OGT intron retention is a key component in OGT expression and maintaining O-GlcNAc homeostasis.
Multiparameter Flow Cytometry: Advances in High Resolution Analysis
Erika A O’Donnell,David N Ernst,Ravi Hingorani 대한면역학회 2013 Immune Network Vol.13 No.2
Over the past 40 years, flow cytometry has emerged as a leading, application-rich technology that supports high-resolution characterization of individual cells which function in complex cellular networks such as the immune system. This brief overview highlights advances in multiparameter flow cytometric technologies and reagent applications for characterization and functional analysis of cells modulating the immune network. These advances significantly support highthroughput and high-content analyses and enable an integrated understanding of the cellular and molecular interactions that underlie complex biological systems.
Multiparameter Flow Cytometry: Advances in High Resolution Analysis
O'Donnell, Erika A.,Ernst, David N.,Hingorani, Ravi The Korean Association of Immunobiologists 2013 Immune Network Vol.13 No.2
Over the past 40 years, flow cytometry has emerged as a leading, application-rich technology that supports high-resolution characterization of individual cells which function in complex cellular networks such as the immune system. This brief overview highlights advances in multiparameter flow cytometric technologies and reagent applications for characterization and functional analysis of cells modulating the immune network. These advances significantly support highthroughput and high-content analyses and enable an integrated understanding of the cellular and molecular interactions that underlie complex biological systems.
Health Promotion : An Emerging Strategy for Health Enhancement and Business Cost Savings in Korea
O'Donnell, Michael P. Korean Society for Health Education and Promotion 1999 International Symposium Vol.1999 No.-
· Half of deaths are caused by life-style related problems in developed nations. · Health promotion can improve life-style and health. · Improvements in life-style and health lead to savings in medical care core costs and enghancements in productivity. · Win-Win-Win-Win : Management, Labor, Employees and Government benefit