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        The Risk of Multimorbidity Associated with Overweight and Obesity: Data from the Brazilian National Health Survey 2013

        Thaynã Ramos Flores,Ana Paula dos Santos Rodrigues,Rosália Garcia Neves,Sandro Rodrigues Batista,Doralice Severo da Cruz Teixeira,Erika Aparecida da Silveira,Deborah Carvalho Malta,Bruno Pereira Nunes 대한비만학회 2021 The Korean journal of obesity Vol.30 No.2

        Background: An increase in body mass index (BMI) is strongly associated with the occurrence of multimorbidity, and overweight and obesity are contributing factors for the increase in morbidities. Thus, the present study aimed to evaluate the occurrence of multimorbidity and associated factors in Brazilian adults with and without overweight or obesity. Methods: This was a cross-sectional population-based study with data from the National Health Survey (2013) including individuals aged 18 years or older. Multimorbidity was defined as having ≥2 diseases from the list of 15 morbidities on the self-reported questionnaire (self-reported medical diagnosis in life). BMI was categorized as: ≤24.9 kg/m2 (low weight and eutrophy), 25.0–29.9 kg/m2 (overweight), and ≥30.0 kg/m2 (obesity). Sex, age, and schooling were the covariates. Poisson regression was used for crude and adjusted analyses for the variables representing access to health services estimating the prevalence ratio (PR) and 95% confidence interval (CI). Results: The total sample consisted of 59,402 individuals. The prevalence of multimorbidity was 25% overall and was higher among overweight (25.8%) and obese (32.5%) individuals. Obese women 60 years or older had a higher occurrence of multimorbidity (80%). In the adjusted analysis, a lower prevalence of multimorbidity was observed among those with higher educational levels in all BMI classifications: low weight/eutrophy, PR=0.66 (95% CI, 0.58–0.75); overweight, PR=0.62 (95% CI, 0.56–0.70); and obesity, PR=0.75 (95% CI, 0.67–0.85). Conclusion: A higher prevalence of multimorbidity was found among obese women who were 60 years of age or older. Schooling was an associated factor regardless of BMI.

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        Miller Fisher Syndrome in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Systematic Review

        Martins-Filho Paulo Ricardo,Pereira de Andrade Ana Luiza,Pereira de Andrade Ana Júlia,Moura da Silva Maria Daniella,de Souza Araújo Adriano Antunes,Nunes Paula Santos,Santos Victor Santana,Ferreira Li 대한신경과학회 2021 Journal of Clinical Neurology Vol.17 No.4

        Background and Purpose Miller Fisher syndrome (MFS) is a subtype of Guillain-Barré syndrome characterized by the triad of ophthalmoparesis, areflexia, and ataxia. Although cases of MFS have been associated with severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2) infection, no studies have synthesized the clinical characteristics of patients with this condition. Methods In this rapid systematic review, we searched the PubMed database to identify studies on MFS associated with SARS-CoV-2 infection. Results This review identified 11 cases, of whom 3 were hospitalized with motor and/or sensory polyneuropathy as the first sign of SARS-CoV-2 infection. SARS-CoV-2 RNA was not detected in analyses of cerebrospinal fluid, suggesting a mechanism of immune-mediated injury rather than direct viral neurotropism. However, antiganglioside antibodies were found in only two of the nine patients tested. It is possible that target antigens other than gangliosides are involved in MFS associated with SARS-CoV-2 infection. Conclusions The present patients exhibited clinical improvement after being treated with intravenous immunoglobulin. Although rare, patients with SARS-CoV-2 infection may present neurological symptoms suggestive of MFS. Early recognition of the MFS clinical triad is essential for the timely initiation of treatment.

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