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Self-propelled Adaptive Electrophoretic Drug Diffusion Device Using Piezoelectric Gradient
Abisegapriyan KS(K.S. 아비세가프리얀),Nirmal Prashanth Maria Joseph (니르말 프라샨스 마리아 조셉 라즈),Sang-Jae Kim(김상재) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.4
A piezoelectric-driven electroporation system is developed for transdermal drug delivery with an adaptive diffusion rate for improved patient comfort and compliance. A miniaturized in-situ piezo-electrophoretic membrane was designed to trigger the electro-responsive drug carrier and activate the electrophoretic treatment for enhanced drug delivery efficiency through biomechanical motion. In this system, a flexible transdermal patch, with a bio-inspired integration of Agarose-BNKT based permeable membrane, was adopted to ensure stable drug diffusion due to an applied pressure gradient. The integrated system efficiently releases a drug dosage of 5 μg/cm<sup>2</sup> per minute by tapping over the patch. Furthermore, the system has achieved an adaptable drug release rate from 0.15 to 0.35 μg/cm<sup>2</sup> per minute by varying the finger winding (bending angle of the patch). Our results demonstrate that the proposed system is intended to provide patients with an easy approach to achieve a customized rate and dosage of drug release and expanding the applications of biocompatible piezo-materials and devices.