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Lsolation of Diterpene acid from Anisotome Lyallii
Lim, Jin A,Choi, Eun Young,Oh, In Kio,Kim, Hyung Min,Kim, Young Ok,Perry, Nigel B,Baek, Seung Hwa 대한동의생리학회,대한동의병리학회 2003 동의생리병리학회지 Vol.17 No.4
The diterpene acid 1 was isolated from the roots of Anisotome lyallii (Apiaceae/Umbelliferae). The structure of. the compound was elucidated as anisommenoic acid 1 on the basis of spectroscopic methods. This compound was evaluated against P388 murine leukaemia and B 16/F10 melanoma cells.
Cytotoxic Activity of $13(E)-labd-13-ene-8{\alpha}$, 15-diol on Human Epithelioid Carcinoma Cells
Lim, Jin-A,Kwag, Jung-Sook,Perry, Nigel B.,Kim, Il-Kwang,Baek, Seung-Hwa The Physiological Society of Korean Medicine and T 2005 동의생리병리학회지 Vol.19 No.1
The cytotoxic activity of $13(E)-labd-13-ene-8{\alpha}$, 15-diol (1), isolated from the ethanol extract of Brachyglottis monroi, was evaluated against human oral epithelioid carcinoma cells(KB).
Pharmacological Effects of Bioactive Fractions from Brachyglottis monroi
Kwag Jung Sook,Na Young Soon,Perry Nigel B.,Kim Hyung Min,Baek Seung Hwa The Physiological Society of Korean Medicine and T 2004 동의생리병리학회지 Vol.18 No.1
The effects of bioactive fractions from Brachyglottis monroi on biological activity were investigated. this bioactive subfraction 6-5 is the most cytotoxic to P388 murine leukaemia cell lines. A comparison of IC/sub 50/ values of these subfraction in cancer cell lines showed that their susceptibility to these subfractions decreased in the following order; Fr. 6-5 > Fr. 6-3 > Fr. 6-6 > Fr. 6-1 > Fr. 6-2 > Fr. 6-4 by the MTT method. Silica gel flash column chromatography concentrated the cytotoxic activity in subfraction 6-5 which eluted with 30% and 40% ethyl acetate : hexane gave a major bioactive (51 mg, P388 IC/sub 50/ 8,286 ng/mL at 7.5 ㎍/disc).
Pharmacological Screening of Crude Extracts from Medicinal Plants (I)
Oh Hyun Ju,Kwag Jung Sook,Kim Myung Ju,Perry Nigel B.,Na Young Soon,Kim Hyung Min,Baek Seung Hwa The Physiological Society of Korean Medicine and T 2004 동의생리병리학회지 Vol.18 No.1
The effects of crude extracts from medicinal plants on biological activity were investigated. The crude ethanol extract of H. paucistipula inhibited the growth of the Gram positive bacterium Bacillus subtilis ATCC 19659, (2 mm inhibition zone at 150 ㎍/disc) and the dermatophyte Trichophyton mentagrophytes ATCC 28185, (7 mm inhibition zone at 150 ㎍/disc), and toxic to P388 murine leukaemia cells ATCC CCL 46 P388D1, (IC/sub 50/ 2.48 ㎍/㎖ at 75 ㎍/disc). This crude ethanol extract of H. paucistipula is the strongest antimicrobial and cytotoxic activities against P388 murine leukaemia cells ATCC CCL 46 P388D1.