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Nhiem, Nguyen X.,Kiem, Phan V.,Minh, Chau V.,Kim, Nanyoung,Park, SeonJu,Lee, Hwa Young,Kim, Eun Sil,Kim, Young Ho,Kim, Sohyun,Koh, Young-Sang,Kim, Seung Hyun American Chemical Society and American Society of 2013 Journal of natural products Vol.76 No.4
<P>Three new diarylheptanoids, (3<I>S</I>,5<I>R</I>)-3-hydroxy-5-methoxy-1,7-bis(4-hydroxyphenyl)-6<I>E</I>-heptene (<B>1</B>), (3<I>S</I>,5<I>S</I>)-3-hydroxy-5-methoxy-1,7-bis(4-hydroxyphenyl)-6<I>E</I>-heptene (<B>2</B>), and (3<I>S</I>)-3-hydroxy-1,7-bis(4-hydroxyphenyl)-6<I>E</I>-hepten-5-one (<B>3</B>), four new flavonoid glycosides, 3,7,3′-tri-<I>O</I>-methylquercetin-4′-<I>O</I>-β-<SMALL>d</SMALL>-apiofuranosyl-(1→2)-<I>O</I>-β-<SMALL>d</SMALL>-glucopyranoside (<B>4</B>), 7,3′-di-<I>O</I>-methylquercetin-4′-<I>O</I>-β-<SMALL>d</SMALL>-glucopyranosyl-3-<I>O</I>-[6‴-(3-hydroxy-3-methylglutaroyl)]-α-<SMALL>d</SMALL>-glucopyranoside (<B>5</B>), 7,3′-di-<I>O</I>-methylquercetin-4′-<I>O</I>-β-<SMALL>d</SMALL>-glucopyranosyl-3-<I>O</I>-[(6′′′′′→5′′′′)-<I>O-</I>1′′′′′-(sinap-4-yl)-β-<SMALL>d</SMALL>-glucopyranosyl-6‴-(3-hydroxy-3-methylglutaroyl)]-α-<SMALL>d</SMALL>-glucopyranoside (<B>6</B>), and (2<I>S</I>)-5-hydroxy-7,3′-dimethoxyflavanone-4′-<I>O</I>-β-<SMALL>d</SMALL>-apiofuranosyl-(1→5)-<I>O</I>-β-<SMALL>d</SMALL>-apiofuranosyl-(1→2)-<I>O</I>-β-<SMALL>d</SMALL>-glucopyranoside (<B>9</B>), and 17 known compounds were isolated from the leaves and twigs of <I>Viscum album</I>. Compounds <B>1</B>, <B>4</B>, and <B>19</B> significantly inhibited LPS-stimulated production of TNF-α, IL-6, and IL-12p40 with IC<SUB>50</SUB> values ranging from 0.09 ± 0.01 to 8.96 ± 0.45 μM. (+)-Medioresinol (<B>13</B>) showed inhibitory effects on LPS-stimulated production of IL-12p40 with an IC<SUB>50</SUB> value of 2.00 ± 0.15 μM.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2013/jnprdf.2013.76.issue-4/np300490v/production/images/medium/np-2012-00490v_0003.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np300490v'>ACS Electronic Supporting Info</A></P>
Nhiem, Nguyen Xuan,Kiem, Phan Van,Minh, Chau Van,Ban, Ninh Khac,Cuong, Nguyen Xuan,Tung, Nguyen Huu,Ha, Le Minh,Ha, Do Thi,Tai, Bui Huu,Quang, Tran Hong,Ngoc, Tran Minh,Kwon, Young-In,Jang, Hae-Dong,K The Pharmaceutical Society of Japan 2010 Chemical & pharmaceutical bulletin Vol.58 No.5
<P>Fourteen cucurbitane-type triterpene glycosides (1—14) were isolated from a methanol extract of <I>Momordica charantia</I> fruits, including three new compounds, charantosides A—C (1, 5, 6). Their structures were elucidated by chemical and spectroscopic methods. All isolated compounds were evaluated for α-glucosidase inhibitory effect. Of which, 12 and 13 showed moderate inhibitory activity against α-glucosidase. Whereas, 2, 3, 6—11, and 14 showed weak inhibitory activity, and 1, 4, and 5 were inactive.</P>
Lupane Triterpene Glycosides from Leave of <i>Acanthopanax koreanum</i> and Their Cytotoxic Activity
Nhiem, Nguyen Xuan,Tung, Nguyen Huu,Kiem, Phan Van,Minh, Chau Van,Ding, Yan,Hyun, Jae-Hee,Kang, Hee-Kyoung,Kim, Young Ho The Pharmaceutical Society of Japan 2009 Chemical & pharmaceutical bulletin Vol.57 No.9
<P>One new lupane-triterpene glycoside, acankoreoside I (1), and four known compounds, acankoreoside A (2), acankoreoside D (3), acankoreoside F (4), and acantrifoside A (5), were isolated from the leaves of <I>Acanthopanax koreanum</I> (Araliaceae). Their chemical structures were elucidated by mass, 1D- and 2D-NMR spectroscopy. The structure of new compound 1 was determined to be 3α,11α,30-trihydroxylup-23-al-20(29)-en-28-oic acid 28-<I>O</I>-[α-<SMALL>L</SMALL>-rhamnopyranosyl-(1→4)-β-<SMALL>D</SMALL>-glucopyranosyl-(1→6)-β-<SMALL>D</SMALL>-glucopyranosyl] ester. The cytotoxic activities of these compounds were evaluated with four cancer cell lines such as A-549 (lung), HL-60 (acute promyelocytic leukemia), MCF-7 (breast), and U-937 (leukemia). Compound 1 showed growth inhibitory effect in A-549, HL-60, and MCF-7 cell lines with the IC<SUB>50</SUB> values of 8.2 μ<SMALL>M</SMALL>, 12.1 μ<SMALL>M</SMALL>, and 28.6 μ<SMALL>M</SMALL>, respectively, whereas it was less active in the U937 cell line (the IC<SUB>50</SUB> >100 μ<SMALL>M</SMALL>).</P>
Nhiem, Nguyen Xuan,Kiem, Phan Van,Minh, Chau Van,Tai, Bui Huu,Cuong, Nguyen Xuan,Thu, Vu Kim,Anh, Hoang Le Tuan,Jo, Sung-Hoon,Jang, Hae-Dong,Kwon, Young-In,Kim, Young Ho The Pharmaceutical Society of Japan 2010 Chemical & pharmaceutical bulletin Vol.58 No.10
<P>One new monoterpenoid glycoside, myresculoside (<B>1</B>), and eleven known compounds, were isolated from methanol extract of <I>Myrica esculenta</I> leaves by repeated column chromatography. The effects of these compounds on angiotensin I-converting enzyme (ACE) inhibition were investigated. Compounds <B>3</B> and <B>4</B> showed the most potent ACE inhibition with rates of 29.97% and 25.63% at concentration of 100 μ<SMALL>M</SMALL>, respectively. Compounds <B>5</B>, <B>6</B>, and <B>11</B> showed weak activity with inhibitory rates of 0.07—1.41% at concentration of 100 μ<SMALL>M</SMALL>.</P>
Cucurbitane-type triterpene glycosides from the fruits of Momordica charantia
Nhiem, Nguyen Xuan,Kiem, Phan Van,Minh, Chau Van,Ban, Ninh Khac,Cuong, Nguyen Xuan,Ha, Le Minh,Tai, Bui Huu,Quang, Tran Hong,Tung, Nguyen Huu,Kim, Young Ho John Wiley Sons, Ltd. 2010 Magnetic resonance in chemistry Vol.48 No.5
<P>The chemical study of Momordica charantia fruits led to the isolation of three new cucurbitane triterpene glycosides, momordicosides U, V, and W (1–3). The structures of these compounds were determined to be (19R, 23R)-5β, 19-epoxy-19-methoxycucurbita-6,24-diene-3β, 23-diol 3-O-β-D-allopyranoside (1), (23R)-5β, 19-epoxycucurbita-6,24-diene-3β, 23-diol 3-O-β-D-allopyranoside (2), and (19R)-5β, 19-epoxy-19,25-dihydroxycucurbita-6,23(E)-diene-3β-ol 3-O-β-D-glucopyranoside (3), by chemical and spectroscopic methods. Copyright © 2010 John Wiley & Sons, Ltd.</P> <B>Graphic Abstract</B> <P>Three new cucurbitane triterpene glycoside named momordicosides U-W (1–3), respectively, have been isolated from Momordica charantia. Their chemical structures were identified by chemical and spectroscopic methods. <img src='wiley_img_2010/07491581-2010-48-5-MRC2582-gra001.gif' alt='wiley_img_2010/07491581-2010-48-5-MRC2582-gra001'> </P>
Tan Nhiem Ly,박상권 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.67 No.-
In this study, we fabricated hierarchically self-assembled thin films composed of graphene oxide (GO) sheets and gold nanoparticles (Au NPs) using the Langmuir–Blodgett (LB) and Langmuir–Schaefer (LS) techniques and investigated their gas-sensing performance. First, a thermally oxidized silicon wafer (Si/SiO2) was hydrophobized by depositing the LB films of cadmium arachidate. Thin films of ligand-capped Au NPs and GO sheets of the appropriate size were then sequentially transferred onto the hydrophobic silicon wafer using the LB and the LS techniques, respectively. Several different films were prepared by varying the ligand type, film composition, and surface pressure of the spread monolayer at the air/water interface. Their structures were observed by scanning electron microscopy (SEM) and atomic force microscopy (AFM), and their gas-sensing performance for NH3 and CO2 was assessed. The thin films of dodecanethiol-capped Au NPs and medium-sized GO sheets had a better hierarchical structure with higher uniformity and exhibited better gas-sensing performance.
Tan Nhiem Ly,Sangkwon Park 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.91 No.-
In this study, we fabricated sensors to detect Alzheimer’s disease (AD) biomarkers – amyloid beta (1-42)(Aβ1-42) based on localized surface plasmon resonance (LSPR). The sensors were consisted of ligandexchangedgold nanoparticles (Au NPs) deposited on polyethylene terephthalate substrate usingLangmuir-Blodgett (LB) technique. Monoclonal antibodies (anti-Aβ1-42) were then immobilized as aconjugate form with biotin onto the LBfilms of ligand-exchanged Au NPs by the aid of streptavidin. Theattachment of the biomarkers to the antibodies immobilized on the LBfilms was detected by measuringabsorbance change of plasmonic response peak. The sensor structure was optimized by comparing theresults for the Au NPs LBfilms with different size andfilm thickness. The optimized sensor was used todetect biomarker at different concentrations in the buffer solution and a diluted cerebrospinalfluid (CSF)solution. As results, the sensor was able to detect even a trace amount of Aβ1-42 as small as 1 pg/ml fromthe CSF. This prototype sensor has a great potential because it shows several advantages of facile andinexpensive fabrication, and early detection of the AD.
Wearable strain sensor for human motion detection based on ligand-exchanged gold nanoparticles
Tan Nhiem Ly,Sangkwon Park 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.82 No.-
A wearable strain sensor consisting thinfilms of organic ligand-exchanged gold nanoparticles (Au NPs)was fabricated and optimized by tuning particle size, ligand chain length, number of layers and substratethickness. The thinfilms of 5 layers of 8-mercaptooctanoic acid-exchanged Au NPs with size of 9 nmdeposited on polydimethylsiloxane substrate exhibited the best performance with excellent gauge factor,high sensitivity, and good reproducibility. The sensor was able to monitor human motions induced byfinger and wrist movements. In addition to facile fabrication, this prototype version of wearable strainsensor appears to be practically feasible for the detection of minute human motions.