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- 저자 : Neetu Rajput (검색결과 2 건)
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US RAJPUT,NEETU KANAUJIA 한국산업응용수학회 2018 Journal of the Korean Society for Industrial and A Vol.22 No.4
The present study is carried out to examine the combined effect of heat absorption on flow model. The model consists of unsteady flow of a viscous, incompressible and electrically conducting fluid. The flow is along an impulsively started oscillating vertical plate with variable mass diffusion. The magnetic field is applied perpendicular to the plate. The fluid model under consideration has been solved by Laplace transform technique. The numerical data obtained is discussed with the help of graphs and table. The numerical values obtained for skin-friction have been tabulated. To shorten the lengthy equations in the solution some symbols have been assumed, which are mentioned in appendix. The appendix is included in the article as the last section of the manuscript.
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Disposition kinetics and urinary excretion of cefpiromeafter intravenous injection in buffalo calves
Harpal S. Sandhu,Neetu Rajput,Vinod K. Dumka 대한수의학회 2007 JOURNAL OF VETERINARY SCIENCE Vol.8 No.1
We investigated the disposition kinetics and urinary excretion of cefpirome in buffalo calves after a single intravenous administration of 10 mg/kg. Also, an appropriate dosage regimen was calculated. At 1 min after injection, the concentration of cefpirome in the plasma was 57.4 ± 0.72 μg/ml, which declined to 0.22 ± 0.01 μg/ml at 24 h. The cefpirome was rapidly distributed from the blood to the tissue compartment as shown by the high distribution coefficient values (8.67 ± 0.46/h), and by the drug’s rate of transfer constant from the central to the peripheral compartment, K12 (4.94 ± 0.31/h). The elimination halflife and the volume of distribution were 2.14 ± 0.02 h and 0.42 ± 0.005 l/kg, respectively. Once the distribution equilibrium was reached between the tissues and plasma, the total body clearance (ClB) and the ratio of the drug present in the peripheral to the central compartment (T/P ratio) were 0.14 ± 0.002 l/kg/h and 1.73 ± 0.06, respectively. Based on the pharmacokinetic parameters we obtained, an appropriate intravenous cefpirome dosage regimen for treating cefpiromesensitive bacteria in buffalo calves would be 8.0 mg/kg repeated at 12 h intervals for 5 days, or until persistence of the bacterial infection occurred.
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