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- 저자 : Nadana Saravanan (검색결과 1 건)
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Antioxidant Effect of Hemidesmus indicus on Ethanol-Induced Hepatotoxicity in Rats
Namasivayam Nalini,Nadana Saravanan 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.4
The antioxidant effect of the ethanolic root extract of Hemidesmus indicus, an indigenous Ayurvedic medici-nal plant used in soft drinks in India, was studied in rats with ethanol-induced hepatotoxicity. Administering 20% ethanol (5liver/body weight ratio. The liver marker enzymes, aspartate transaminase (AST), alanine transaminase (ALT), alkaline phos-phatae (ALP), .-glutamyl transpeptidase (GGT), and lactate dehydrogenase (LDH), were elevated. In addition, the levels ofplasma, erythrocyte, and hepatic thiobarbituric acid-reactive substances (TBARS), hydroperoxides (LOOH), and conjugateddienes (CD) were also elevated in ethanol-fed rats as compared to those of the experimental control rats. Decreased activitiesof superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), vitamin C, and. H.indicuswas administered at a dose of 500 mg/kg of body weight/day for the last 30 days of the experiment to rats with ethanol-induced liver injury, which significantly increased body weight, significantly decreased the liver/body weight ratio, AST, ALT,ALP, GGT, and LDH activities, and also the levels of TBARS, LOOH, and CD, significantly elevated the activities of SOD,CAT, GPx, and GSH in plasma, erythrocytes, and liver, and also increased levels of plasma and liver vitamin C and vitaminE at the end of the experimental period as compared to those of untreated ethanol-administeredd rats. Thus, our data indicatethat treatment with H. indicusand liver of animals with ethanol-induced liver injury.
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