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Kim, Chongtae,Jeong, Da Eun,Heo, Sungeun,Ji, Eunbyul,Rho, Jun Gi,Jung, Myeongwoo,Ahn, Sojin,Kim, Ye‐,Jin,Kim, Yong‐,Sung,Nam, Suk Woo,Kulkarni, Rohit N,Lee, Kyoung Bun,Lee, Eun Kyung,Kim, Longman 2018 The Journal of pathology Vol.246 No.2
<P><B>Abstract</B></P><P>For the majority of patients diagnosed with pancreatic neuroendocrine tumors (NETs), there is significant malignant potential with a poor prognosis; however, the molecular abnormalities and pathogenesis of pancreatic NETs have not been firmly established. Here, we report that loss of expression of the RNA‐binding protein HuD correlates with low p27<SUP>Kip1</SUP> (p27) levels and poor prognosis in pancreatic NETs. HuD expression was frequently lost in many human pancreatic NETs, and these pancreatic NETs showed aggressive clinicopathological phenotypes with low p27 levels, increased tumor size, higher World Health Organization grade and pT stage of the tumor, and the presence of angioinvasion. Furthermore, loss of HuD was an independent, progression‐free prognostic factor in multivariate survival analysis. However, the level of HuR, a member of the same Hu protein family as HuD, was not significantly correlated with pancreatic NET size and progression. Mechanistically, HuD enhanced <I>p27</I> mRNA translation by interacting with both the 5′‐untranslated region (UTR) and the 3′‐UTR of <I>p27</I> mRNA, and consequently suppressed cell cycle progression and tumor growth. In addition, HuD competed with miR‐30a‐3p for binding to the 3′‐UTR of <I>p27</I> mRNA, suggesting an interplay between HuD and miR‐30a‐3p in controlling <I>p27</I> translation. Our results identify HuD as a pivotal suppressor of pancreatic NET growth, and suggest that HuD has potential value as a prognostic factor of pancreatic NETs. Copyright © 2018 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.</P>
부유식 해상풍력발전기의 자세제어장치 개발을 위한 환형 실린더 탱크의 슬로싱 실험
서명우(Seo, Myeongwoo),정의봉(Jeong, Weuibong),조진래(Cho, Jinrae) 한국소음진동공학회 2013 한국소음진동공학회 논문집 Vol.23 No.1
The floating offshore wind turbines are usually exposed to the wave and wind excitations which are irregular and undirected. In this paper, the sloshing characteristics of annular cylindrical tank were experimentally investigated to reduce the structural dynamic motion of floating offshore wind turbine which is robust to the irregular change of excitation direction of wind and wave. The formula for the natural sloshing frequencies of this annular cylindrical tank was derived theoretically. In order to validate this formula, the shaking equipment was established and frequency response functions were measured. Two types of tank were considered. The first and second natural sloshing frequencies were investigated according to the depth of the water. It has been observed that between theoretical and experimental results shows a good agreement.
Range-only Relative Position Estimation for Multi-UAV
Junho Choi,Eungchang Lee,Myeongwoo Jeong,Duckyu Choi,Hyun Myung 제어로봇시스템학회 2022 제어로봇시스템학회 국제학술대회 논문집 Vol.2022 No.11
Although a UAV itself is adaptable to variety of tasks, its low payload and short flight time limit its usage. As a way to overcome the limitations of a UAV, a multi-UAV system is being researched. In order to utilize the Multi-UAV system, it is essential to estimate the relative position of each UAV. In this paper, a relative position estimation method is proposed that requires only range measurements from each pair of UAV combinations. The positions of UAVs are estimated by minimizing the difference between the range measurements and the distance values which are calculated from each pair of estimated positions of UAVs. The performance of the proposed method is verified by five UAVs flight simulation. The range data are generated from the ground-truth positions of five UAVs and Gaussian noise added range data are used for the experiments.
Ji, Eunbyul,Lee, Heejin,Ahn, Sojin,Jung, Myeongwoo,Lee, Sung Hak,Lee, Jeong-Hwa,Lee, Eun Kyung Elsevier 2019 Biochemical and biophysical research communication Vol.513 No.1
<P><B>Abstract</B></P> <P>Autophagy, a lysosomal self-degradative process of cellular components, is essential for cellular homeostasis to response cellular stress and is tightly controlled by autophagy-related genes (ATGs). Autophagy-related gene 6 (ATG6, also known as Beclin-1 in human) is an essential factor regulating autophagy and apoptosis. RNA binding proteins (RBPs) regulate gene expression at the post-transcriptional level and their differential expression is linked to the pathogenesis of several human diseases. Here, we demonstrate the role of heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) as a novel factor regulating ATG6 expression. hnRNPA1 associates with the 3′ untranslated region (3′UTR) of <I>ATG6</I> mRNA and promotes its expression without significant changes at the mRNA level. Knockdown of hnRNPA1 decreases ATG6 expression, which is enhanced by the overexpression of hnRNPA1. Also, we show augmented expression of both hnRNPA1 and ATG6 in the colorectal cancer (CRC) tissues obtained from patients and demonstrate a positive correlation of their expression in CRC tissues. Our results suggest the potential role of hnRNPA1-mediated ATG6 regulation in the pathogenesis of CRC.</P> <P><B>Highlights</B></P> <P> <UL> <LI> hnRNPA1 binds to the 3′UTR of <I>ATG6</I> mRNA. </LI> <LI> hnRNPA1 positively regulates ATG6 expression. </LI> <LI> hnRNPA1 and ATG6 is augmented in the cancerous tissues obtained from CRC patients. </LI> <LI> hnRNPA1 level positively correlates to ATG6 level in CRC tissues. </LI> </UL> </P>