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Arshad Ali,Farman Ullah,Irum Sabir Ali,Ahmad Faraz,Mumtaz Khan,Syed Tahir Ali Shah,Nawab Ali,Muhammad Saeed 한국유방암학회 2016 Journal of breast cancer Vol.19 No.2
Purpose: The promoter methylation status of cell cycle regulatory genes plays a crucial role in the regulation of the eukaryotic cell cycle. CpG cytosines are actively subjected to methylation during tumorigenesis, resulting in gain/loss of function. E2F5 gene has growth repressive activities; various studies suggest its involvement in tumorigenesis. This study aims to investigate the epigenetic regulation of E2F5 in breast cancer to better understand tumor biology. Methods: The promoter methylation status of 50 breast tumor tissues and adjacent normal control tissues was analyzed. mRNA expression was determined using SYBR® green quantitative polymerase chain reaction (PCR), and methylation- specific PCR was performed for bisulfite-modified genomic DNA using E2F5-specific primers to assess promoter methylation. Data was statistically analyzed. Results: Significant (p<0.001) upregulation was observed in E2F5 expression among tumor tissues, relative to the control group. These samples were hypo-methylated at the E2F5 promoter region in the tumor tissues, compared to the control. Change in the methylation status (Δmeth) was significantly lower (p=0.022) in the tumor samples, indicating possible involvement in tumorigenesis. Patients at the postmenopausal stage showed higher methylation (75%) than those at the premenopausal stage (23.1%). Interestingly, methylation levels gradually increased from the early to the advanced stages of the disease (p<0.001), which suggests a putative role of E2F5 methylation in disease progression that can significantly modulate tumor biology at more advanced stage and at postmenopausal age (Pearson’s r=0.99 and 0.86, respectively). Among tissues with different histological status, methylation frequency was higher in invasive lobular carcinoma (80.0%), followed by invasive ductal carcinoma (46.7%) and ductal carcinoma in situ (20.0%). Conclusion: Methylation is an important epigenetic factor that might be involved in the upregulation of E2F5 gene in tumor tissues, which can be used as a prognostic marker for breast cancer.
The Relationship Between Despotic Leadership and Employee Outcomes: An Empirical Study from Pakistan
KHAN, Hafiz Ghufran Ali,AHMED, Irshad,Ul AIN, Qurat,MUMTAZ, Roohi,IKRAM, Memoona Korea Distribution Science Association 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.6
Through emotional exhaustion, this study empirically tests followers' behavioral responses to autocratic leaders. The current research focuses on effects caused by despotic leadership on followers' emotional exhaustion, which leads to employee outcomes such as interpersonal deviances and indirect aggression. The association between despotic leadership and results (employee interpersonal deviance and indirect violence) is investigated in this study. In this study, emotional exhaustion is used as a mediator. Furthermore, negative affectivity is used as a moderator between despotic leadership and emotional exhaustion. A time-lagged framework is employed with a sample of 255 respondents. Age, qualification, marital status, gender, grade, type of organization, department, and job experience are among the eight demographical questions in this study. After evaluating the data for normality, correlation analysis was performed, followed by moderation and mediation analysis. The current study explores the link between despotic leadership and emotional exhaustion among followers, arguing that a despotic leader will leave followers exhausted at work. Emotional exhaustion was also linked to interpersonal deviances, such as indirect aggression, in a significant and positive way. Employee outcomes, such as interpersonal deviances and indirect aggressiveness through emotional exhaustion, will be influenced by a despotic leader, according to the findings.
Islam Tahir,Khan Mumtaz,Ghaffar Abdul,Wang Ying,Mubarik Muhammad Shujaat,Ali Imtiaz Haider,Shahid Zubair Ali,Rehmani Mahmood,Sharma Anshuman 한국마케팅과학회 2023 마케팅과학연구 Vol.33 No.1
This research examines the underlying mechanism through which corporate social responsibility (CSR) influences customer loyalty in the hospitality sector. A survey conducted in three popular tourist cities in China reveals that CSR positively impacts customer loyalty through institutional-level constructs, including corporate image and sustained competitive advantage, and individual-level constructs, including customer trust and customer satisfaction. Moreover, the core capabilities of organizations moderate the effect of CSR on corporate image and sustained competitive advantage. Corporate image sustained advantage, and customer satisfaction also mediates the relationship between CSR and customer loyalty. The theoretical and practical implications of these findings are discussed.
Partial fetotomy : technique to resolve wry neck dystocia in mare
Mubbashar Hassan,Sana Shahid,Akhtar Rasool Asif,Muhammad Ilyas Naveed,Abid Hussain Shahzad,Mumtaz Ali Khan 한국동물생명공학회(구 한국동물번식학회) 2020 Journal of Animal Reproduction and Biotechnology Vol.35 No.4
Foaling is a process of giving birth to foal which is prompt and forceful event in equine breeding. Dystocia is declared when 2nd stage of parturition exceeds from 20 min without fetal movements in mare. Dystocia is very challenging situation for both mare and veterinarian. Survivability of mare and foal, and subsequent fertility of mare depends on efficient management. Therefore, the current report described a rare case of wry neck (torticollis or unilateral bent neck) resulted in dystocia, that was efficiently resolved by partial fetotomy and repulsion technique in mare under field conditions. Intensive post operative care was performed to avoid infection and to achieve fertility subsequently.
Partial fetotomy: technique to resolve wry neck dystocia in mare
Hassan, Mubbashar,Shahid, Sana,Asif, Akhtar Rasool,Naveed, Muhammad Ilyas,Shahzad, Abid Hussain,Khan, Mumtaz Ali The Korean Society of Animal Reproduction and Biot 2020 한국동물생명공학회지 Vol.35 No.4
Foaling is a process of giving birth to foal which is prompt and forceful event in equine breeding. Dystocia is declared when 2nd stage of parturition exceeds from 20 min without fetal movements in mare. Dystocia is very challenging situation for both mare and veterinarian. Survivability of mare and foal, and subsequent fertility of mare depends on efficient management. Therefore, the current report described a rare case of wry neck (torticollis or unilateral bent neck) resulted in dystocia, that was efficiently resolved by partial fetotomy and repulsion technique in mare under field conditions. Intensive post operative care was performed to avoid infection and to achieve fertility subsequently.