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- 검색키워드
- 저자 : Muhammad Zeeshan Shakir (검색결과 2 건)
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Shahriar Abdullah Al-Ahmed,Muhammad Zeeshan Shakir,Syed Ali Raza Zaidi 한국통신학회 2020 Journal of communications and networks Vol.22 No.6
The rising number of technological advanced devicesmaking network coverage planning very challenging tasks for network operators. The transmission quality between the transmitterand the end users has to be optimum for the best performance outof any device. Besides, the presence of coverage hole is also an ongoing issue for operators which cannot be ignored throughout thewhole operational stage. Any coverage hole in network operators’coverage region will hamper the communication applications anddegrade the reputation of the operator’s services. Presently, thereare techniques to detect coverage holes such as drive test or minimization of drive test. However, these approaches have many limitations. The extreme costs, outdated information about the radioenvironment and high time consumption do not allow to meet therequirement competently. To overcome these problems, we take advantage of Unmanned aerial vehicle (UAV) and Q-learning to autonomously detect coverage hole in a given area and then deployUAV based base station (UAV-BS) by considering wireless backhaul with the core network and users demand. This machine learning mechanism will help the UAV to eliminate human-in-the-loop(HiTL) model. Later, we formulate an optimisation problem for3D UAV-BS placement at various angular positions to maximisethe number of users associated with the UAV-BS. In summary, wehave illustrated a cost-effective as well as time saving approach ofdetecting coverage hole and providing on-demand coverage in thisarticle.
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Atiq, Ayesha,Shal, Bushra,Naveed, Muhammad,Khan, Adnan,Ali, Jawad,Zeeshan, Sara,Al-Sharari, Shakir D.,Kim, Yeong Shik,Khan, Salman Elsevier 2019 european journal of pharmacology Vol.843 No.-
<P><B>Abstract</B></P> <P>5-Fluorouracil (5-FU) is one of the most commonly prescribed anti-cancer agent. However, its use is associated with several debilitating adverse effects such as intestinal mucositis (IM) and myelosuppression. Oxidative stress and inflammation are major contributors in the development of mucositis. Diadzein is known for its potent anti-inflammatory and anti-oxidative activities from decades. The present study focused on investigating the effects of diadzein on intestinal mucositis induced by 5-FU by mainly focusing on oxidative stress and inflammatory markers in mice. Mucositis was induced in mice by administration of 5-FU (50 mg/kg, i.p.), once daily for three days and diadzein (1, 5, 10 mg/kg) was administered once daily for seven days. Diadzein pretreatment was found to reduce the severity of mucosal injury in a dose-dependent manner. Diadzein significantly reversed weight loss, relieved diarrhea, and improved histopathological deformities associated with inflammation. Moreover, diadzein remarkably improved the intestinal wall histopathology by reducing inflammatory mediators infiltration and prevented suppression of antioxidants (glutathione, glutathione sulfo-transferase, and catalase) by 5-FU administration. Furthermore, nitrite production in intestinal tissue was reduced by diadzein consistent with the observed modulation of inflammatory markers. Additionally, diadzein also improved the amended microflora profile, by reducing the number of pathogenic bacteria and increasing the abundance of probiotics. Taken together, the behavioral, biochemical and histological outcomes of the present study demonstrates that diadzein has significant anti-mucositis properties in 5-FU induced mucositis model, and the attenuative potential of diadzein might be due to inhibition of oxidative stress and inflammatory mediators.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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