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Macasiamenene V, a New Stilbenoid from the Leaves of Macaranga inermis
Muhammad Fajar Aldin,Tjitjik Srie Tjahjandarie,Ratih Dewi Saputri,Mulyadi Tanjung 한국생약학회 2021 Natural Product Sciences Vol.27 No.1
One new compound, macasiamenene V (1), and two known stilbenes (2 - 3) were isolated from Macaranga inermis Pax & K.Hoffm leaves. The structure of 1 was fully assigned based on the information on high-resolution MS and (1D, 2D) NMR spectra. The cytotoxic of compounds 1 - 3 was evaluated against 4T1 and HeLa cells. Compounds 2 - 3 showed high activity against HeLa cells with an IC50 value of 1.09 and 0.88 μg/mL, respectively.
Sesbagrandiflorain F, a New 2-Arylbenzofuran from the Stem Bark of Sesbania grandiflora L.
Mulyadi Tanjung,Muhammad Fajar Aldin,Tjitjik Srie Tjahjandarie,Devina Oktari Rahayu,Alfiah Nur Irza Gunawan,Ratih Dewi Saputri 한국생약학회 2021 Natural Product Sciences Vol.27 No.3
Sesbagrandiflorain F (1), a novel 2-arylbenzofuran, and two more 2-arylbenzofurans (2-3), were isolated from the stem bark of Sesbania grandiflora L. Based on information HRESIMS data, 1D, and 2D NMR spectra, the structure of 1 was fully assigned. Compounds 1-3 were tested for cytotoxicity in MCF-7 and HeLa cells. Compounds 1 and 3 showed moderate activity against MCF-7 cells with an IC50 value of 2.68 and 4.08 µg/mL, respectively. Conversely, all of the isolates were inactive towards HeLa cells.
Two New Flavanones from the Leaves of Flemingia lineata (L.) Aiton
Mulyadi Tanjung,Tjitjik Srie Tjahjandarie,Shola Mardhiyyah,Ghinsha Zakatina Rahman,Muhammad Fajar Aldin,Ratih Dewi Saputri,Norizan Ahmat 한국생약학회 2022 Natural Product Sciences Vol.28 No.1
Three isoprenylated flavanones were isolated from the leaves of Flemingia lineata (L.) Aiton. Among them are two new flavanones, flemilineatins A and B (1-2), along with 6-isoprenyl eridioctyol (3). Their structures were determined using HRESIMS data and NMR spectra. Flavanones 1-3 were assayed in the HeLa cancer cells. Compound 1 showed moderate activity with an IC50 value of 11.2 µM.
Two New Flavanones from the Leaves of Flemingia lineata (L.) Aiton
Tanjung, Mulyadi,Tjahjandarie, Tjitjik Srie,Mardhiyyah, Shola,Rahman, Ghinsha Zakatina,Aldin, Muhammad Fajar,Saputri, Ratih Dewi,Ahmat, Norizan The Korean Society of Pharmacognosy 2022 Natural Product Sciences Vol.28 No.2
Three isoprenylated flavanones were isolated from the leaves of Flemingia lineata (L.) Aiton. Among them are two new flavanones, flemilineatins A and B (1-2), along with 6-isoprenyl eridioctyol (3). Their structures were determined using HRESIMS data and NMR spectra. Flavanones 1 - 3 were assayed in the HeLa cancer cells. Compound 1 showed moderate activity with an IC<sub>50</sub> value of 11.2 μM.
Flavestin K, An Isoprenylated Stilbene from the Leaves of Macaranga recurvata Gage
Tjitjik Srie Tjahjandarie,Mulyadi Tanjung,Ratih Dewi Saputri,Anton Permadi,Muhammad Fajar Aldin,Eva Marliana,Anton Permadi 한국생약학회 2019 Natural Product Sciences Vol.25 No.3
A new isoprenylated stilbene, flavestinK (1) together with two known isoprenylated stilbenes, flavestin B (2), flavestin G (3), and two isoprenilated flavanones, 4-O-methyl-8-isoprenylnaringenin (4) and 8-isoprenyl-5,7-dihydroxyflavanone (5) were isolated from the leaves of Macaranga recurvata Gage. All of the structures have been determined based on HRESIMS, 1D and 2D NMR spectral data. All of the isolated compounds were evaluated for their cytotoxicity against three human cancer cells (HeLa, T47D and WiDr). Compound 1 showed higher activity than doxorubicin against HeLa cells with IC50 value of 13.1 μg/mL.
A New Cinnamyl Acid Derivative from the Roots of Willughbeia coriacea Wall.
Mulyadi Tanjung,Tjitjik Sri Tjahjandarie,Ratih Dewi Saputri,Andre Harsono,Muhammad Fajar Aldin 한국생약학회 2020 Natural Product Sciences Vol.26 No.1
A new cinnamyl acid derivative, willughbein A (1) along with pinoresinol (2), alyterinate A (3), and scopoletin (4), were isolated from the roots of Willughbeia coriacea Wall. The structure of 1 has been determined based on HRESIMS, 1D, and 2D NMR spectral data. All of the isolates were evaluated for their cytotoxicity against three human cancer cells (HeLa, T47D, MCF-7, and P-388). Compound 3 showed moderate activity against P-388 cells with an IC50 value of 3.04 μg/mL.