http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Moqrich, Aziz (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Impaired Thermosensation in Mice Lacking TRPV3, a Heat and Camphor Sensor in the Skin
Moqrich, Aziz,Hwang, Sun Wook,Earley, Taryn J.,Petrus, Matt J.,Murray, Amber N.,Spencer, Kathryn S. R.,Andahazy, Mary,Story, Gina M.,Patapoutian, Ardem American Association for the Advancement of Scienc 2005 Science Vol.307 No.5714
<P>Environmental temperature is thought to be directly sensed by neurons through their projections in the skin. A subset of the mammalian transient receptor potential (TRP) family of ion channels has been implicated in this process. These “thermoTRPs” are activated at distinct temperature thresholds and are typically expressed in sensory neurons. TRPV3 is activated by heat (>33°C) and, unlike most thermoTRPs, is expressed in mouse keratinocytes. We found that TRPV3 null mice have strong deficits in responses to innocuous and noxious heat but not in other sensory modalities; hence, TRPV3 has a specific role in thermosensation. The natural compound camphor, which modulates sensations of warmth in humans, proved to be a specific activator of TRPV3. Camphor activated cultured primary keratinocytes but not sensory neurons, and this activity was abolished in TRPV3 null mice. Therefore, heat-activated receptors in keratinocytes are important for mammalian thermosensation.</P>
-
Heterogeneity in Primary Nociceptive Neurons: From Molecules to Pathology
Eduardo Gascon,Aziz Moqrich 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.10
Pain sensation (nociception) is an alarm system aiming to signal the presence of potentially or actually harmful stimuli. In our hazard-rich environment, pain initiates the necessary reactions to prevent or limit tissue damage in response to noxious inputs playing therefore a crucial survival role. Specialized noxious stimuli detectors, called primary nociceptive neurons or nociceptors transduce and convey pain information to the central nervous system. Unlike other sensory systems, pain sensation could be evoked by a vast range of external or internal stimuli. Nearly any of the environmental stimuli could be potentially noxious depending on their nature and/or intensity and/or duration. Early studies at the beginning of the 20th century identified a discrete number of nociceptive neuronal types according to their electrophysiological responses or their degree of myelination. However, the advent of molecular biology techniques revealed an extraordinary diversity among nociceptors. Such heterogeneity likely reflects the evolutionary adaptation required to respond to an extremely variety of circumstances.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
