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Dual-Chamber Technology: Safe and Convenient Drug Delivery for Lyophilized Biologics
Moore, John Association for Research of MPS and Rare Diseases 2015 Journal of mucopolysaccharidosis and rare disease Vol.1 No.1
Biologics present a challenge to both the manufacturer and end user. They must usually be formulated as parenterals. However, they are often unstable in liquid form, due to their complex structure and composition. In that case, they must be manufactured using highly specialized processes, such as lyophilization (freeze-drying). Lyophilization nearly eliminates stability issues. Reducing a compound's sensitivity to temperature prolongs its shelf life. However, reconstitution can be cumbersome, involving multiple steps that increase the potential for error. Dual-chamber technology provides an effective alternative, combining a lyophilized drug and diluent in a closed system and enabling reconstitution in a few simple steps.
Multilayered Polymer-Coated Carbon Nanotubes To Deliver Dasatinib
Moore, Thomas L.,Grimes, Stuart W.,Lewis, Robert L.,Alexis, Frank American Chemical Society 2014 MOLECULAR PHARMACEUTICS Vol.11 No.1
<P>Multilayered, multifunctional polymer coatings were grafted onto carbon nanotubes (CNTs) using a one-pot, ring-opening polymerization in order to control the release kinetic and therapeutic efficacy of dasatinib. Biocompatible, biodegradable multilayered coatings composed of poly(glycolide) (PGA) and poly(lactide) (PLA) were polymerized directly onto hydroxyl-functionalized CNT surfaces. Sequential addition of monomers into the reaction vessel enabled multilayered coatings of PLA-PGA or PGA-PLA. Poly(ethylene glycol) capped the polymer chain ends, resulting in a multifunctional amphiphilic coating. Multilayer polymer coatings on CNTs enabled control of the anticancer drug dasatinib’s release kinetics and enhanced the in vitro therapeutic efficacy against U-87 glioblastoma compared to monolayer polymer coatings.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/mpohbp/2014/mpohbp.2014.11.issue-1/mp400448w/production/images/medium/mp-2013-00448w_0009.gif'></P>
Moore, Malcolm A,Yoo, Keun-Young,Tuncer, Murat Asian Pacific Organization for Cancer Prevention 2009 Asian Pacific journal of cancer prevention Vol.10 No.1
<P>The Asian Pacific Organization for Cancer Prevention was launched approximately 10 years ago with publication of a booklet entitled 'Introduction to Cancer Prevention in Tables and Figures'. This was followed by regular quarterly publication of the APJCP starting in the year 2000 - a new project for a new millenium - and a number of research meetings held across Asia. The journal is now in its 10th year, indexed on PubMed and Science Citation Index (Expanded) and relatively well known (not least for its yellow cover). However, its future after its tenth birthday remains uncertain, as there is no infrastructure in place to ensure continuation after retirement of the present Chief/Managing Editor. The question of what might be the best way forward is the focus for the present 'Editorial Comment'. For financial as well as ecological reasons the APJCP is now an electronic journal, printing and postage for issues of almost 200 pages being beyond the resources available. While the costs are therefore relatively low and primarily limited to staff salaries, they do need to be covered and it cannot be simply assumed that the present support provided by the UICC Japanese National Committee will continue long-term. Therefore comments and suggestions are invited from all interested individuals and institutions as to how the APJCP, and by extension the APOCP, should be organized and financed. All communications received will be given space in the next few issues of the APJCP so that discussion can be fostered and informed decisions made at the 5th APOCP General Assembly Conference in Istanbul, April 2010.</P>
Iteration domain H<sub>∞</sub>-optimal iterative learning controller design
Moore, Kevin L.,Ahn, Hyo-Sung,Chen, Yang Quan John Wiley Sons, Ltd. 2008 INTERNATIONAL JOURNAL OF ROBUST AND NONLINEAR CONT Vol.18 No.10
<P>This paper presents an H<SUB>∞</SUB>-based design technique for the synthesis of higher-order iterative learning controllers (ILCs) for plants subject to iteration-domain input/output disturbances and plant model uncertainty. Formulating the higher-order ILC problem into a high-dimensional multivariable discrete-time system framework, it is shown how the addition of input/output disturbances and plant model uncertainty to the ILC problem can be cast as an H<SUB>∞</SUB>-norm minimization problem. The distinctive feature of this formulation is to consider the uncertainty as arising in the iteration domain rather than the time domain. An algebraic approach to solving the problem in this framework is presented, resulting in a sub-optimal controller that can achieve both stability and robust performance. The key observation is that H<SUB>∞</SUB> synthesis can be used for higher-order ILC design to achieve a reliable performance in the presence of iteration-varying external disturbances and model uncertainty. Copyright © 2007 John Wiley & Sons, Ltd.</P>
MOORE, ROBERT E. 한국국제경제학회 1990 International Economic Journal Vol.4 No.1
This paper provides an empirical test of the hypothesis that the Japanese government has undertaken a successful strategic trade policy in the semiconductor industry. Quantifiable R & D and tariff policy as they relate to the semiconductor industry and their impact on firms in the US "merchant" semiconductor market are considered. The test results do not support the hypothesis as it applies to government R & D expenditures and tariffs. These Japanese government policies have not had a significant adverse impact on the profits of three important US semiconductor producing firms.
Overview of Cancer Registration Research in the Asian Pacific from 2008-2013
Moore, Malcolm A. Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8
Cancer registration provides a firm basis for cancer control efforts and research into changing patterns of incidence, mortality, survival and prevalence is of obvious importance. Most of the countries of Asia have already published relevant data although the level of coverage and accuracy do vary a great deal both between and within countries. The present review concerns the relevant literature for the period 2008-2013, focusing on the types of research conducted and the conclusions that can be drawn with regard to what should be done in the future to translate the information available into effective intervention efforts to reduce the burden of disease. A major emphasis has been on determining variation in incidence and mortality/survival on the basis of ethnicity and socioeconomic as well as geographical background, as well as trends over time, either for cancer in general or specific organ sites. In addition a small number of papers focused on methodological, quality and cancer control issues, very pertinent to the future development of cancer registry based research.