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In vitro Derby Imaging of Cancer Biomarkers Using Quantum Dots
Ko, Mee Hyang,Kim, Soonhag,Kang, Won Jun,Lee, Jung Hwan,Kang, Hyungu,Moon, Sung Hwan,Hwang, Do Won,Ko, Hae Young,Lee, Dong Soo WILEY-VCH Verlag 2009 Small Vol.5 No.10
<P>Semiconductor quantum dots (QDs), which have broad absorption with narrow emission spectra, are useful for multiplex imaging. Here, fluorescence derby imaging using dual color QDs conjugated by the AS1411 aptamer (targeting nucleolin) and the arginine–glycine–aspartic acid (targeting the integrin α<SUB>v</SUB>β<SUB>3</SUB>) in cancer cells is reported. Simultaneous fluorescence imaging of cellular distribution of nucleolin and integrin α<SUB>v</SUB>β<SUB>3</SUB> using QDs enables easy monitoring of separate targets in the cancer cells and the normal healthy cells. These results suggest the feasibility of a concurrent visualization of QD-based multiple cancer biomarkers using small molecules such as aptamer or peptide ligands.</P> <B>Graphic Abstract</B> <P>In vitro derby imaging of RGD peptide targeting integrin α<SUB>v</SUB>β<SUB>3</SUB> protein (green in image) and AS1411 aptamer targeting nucleolin protein (red) using two different quantum dots (605 and 655 nm) is successfully visualized in HeLa cells, simultaneously. Fluorescent imaging signatures of the overlay (yellow) from the integrin α<SUB>v</SUB>β<SUB>3</SUB> and nucleolin show the co-localization in the cellular membrane. <img src='wiley_img/16136810-2009-5-10-SMLL200801580-content.gif' alt='wiley_img/16136810-2009-5-10-SMLL200801580-content'> </P>
FCP 14 : Screening of psoriatic arthritis in Korean psoriasis patients using PASE questionnaire
( Hyang Suk You ),( Hyun Ho Cho ),( Won Jeong Kim ),( Je Ho Mun ),( Marg Aret Song ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Moon Bum Kim ),( Seung Geun Lee ),( In Sook Lee ),( Byung Soo Kim ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Psoriatic arthritis (PsA) is a chronic seronegative oligoarthritis causing irreversible joint damage. Early recognition of PsA in patients with psoriasis is important to prevent physical disability and deformity. However, diagnosing PsA pose a distinct challenge for most dermatologists in the context of a busy clinic. Objectives: The aim of this study was to validate Psoriatic Arthritis Screening Evaluation (PACE) questionnaire in detecting PsA in Korean patients with psoriasis. Methods: A total 148 patients with a diagnosis of psoriasis, but not previously diagnosed with PsA were administered with PACE questionnaire prospectively. All patients underwent radiologic and laboratory examinations. In addition, they were clinically evaluated by a rheumatologist. Results: Eighteen patients (12.1%) were diagnosed with PsA meeting the Classification Criteria for Psoriatic Arthritis (CASPAR) criteria. The sum of PACE score in patients with PsA showed signifcant difference compared with those without PsA. Receiver operator curves showed an area under the curve of 0.82 (95% CI 0.72, 0.92) for the total score. A cut-off value ≥36 showed sensitivity of 77.8%, and specificity of 82.3% for the diagnosis of PsA. Conclusion: The PACE questionnaire is simple and convenient screening tool for detecting PsA in Korean dermatologic clinic. Dermatologists should consider PASE questionnaire for psoriasis patients attending clinics, as it proved robust for the early identification of PsA.
P263 : Dermatoses of the glans penis and prepuce: single centre experience for 10 years
( Hyang Suk You ),( Hyun Ho Cho ),( Won Jeong Kim ),( Je Ho Mun ),( Margaret Song ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: In the diagnosis of skin diseases, topographic approach is very meaningful. Though a variety of infectious, inflammatory and neoplastic dermatoses can occur in glans and prepuce, establishing the diagnosis may be difficult because their symptoms and clinical appearance can be nonspecific. Furthermore, there has been only limited data for Korean dematoses of glans penis and prepuce. Objectives: The aim of this study was to make a baseline data for Korean dematoses of glans penis and prepuce. Methods: We retrospectively reviewed the medical records, clinical photos and histologic slides of 67 patients with dermatoses of glans and prepuce, who had visited Pusan National University Hospital from January 2004 to August 2013. Results: All patients were circumcised, except one who was infected with chancroid. Skin lesions were confined to only glans in 32 patients (47.8%). There were various kinds of skin diseases (26 diseases). Most frequently diagnosed dermatoses of glans penis and prepuce were seborrheic dermatitis (19.4%), lichen planus (17.9%), herpes progenitalis (5.9%), syphilis (5.9%), condyloma accuminatum (5.9%), erythroplasia of Queyrat (4.5%), Zoon`s balanitis (4.5%), and psoriasis (4.5%). Conclusion: The result of this study could be used as baseline data for Korean dematoses of glans penis and prepuce, and could be useful for topographic approach in Korean dematoses of glans penis and prepuce.
( Hyang-suk Ryu ),( Tae-wook Kim ),( Hyun-joo Lee ),( Sung-min Park ),( Hyunju Jin ),( Woo-haing Shim ),( Gun-wook Kim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-bum Kim ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: A distinctive clinical pattern of alopecia is very important for the differential diagnosis among various alopecia. However, dermatologists may have difficulty making correct diagnosis when alopecia occurred in a linear pattern because their clinical presentation might be extremely rare. Objectives: To identify the clinical and histopathological characteristics of linear alopecia of the scalp in Korean patients Methods: This retrospective study included patients with linear alopecia of the scalp presenting at the Pusan National University Hospital (Busan and Yangsan) during a 15-year period (2002-2017). In all the patients, biopsies were performed and final diagnosis was made based on clinical and histopathologic findings. We reviewed medical records, clinical photos, and histopathological slides. Results: Twenty-one patients with linear alopecia of the scalp were included in this study. The most common dermatoses was En Coup de Sabre (7/21, 33.3%), followed by alopecia areata (5/21, 23.8%), lupus erythematosus (2/21, 9.5%), pseudopelade of Brocq (2/21, 9.5%), non-specific scarring alopecia (2/21, 9.5%), triangular alopecia (1/21, 4.8%), trichotillomania (1/21, 4.8%), and traction alopecia (1/21, 4.8%). Conclusion: The result of this study could be helpful for dermatologits when encounting linear alopecia of the scalp.
Dermatoses of the Glans Penis in Korea: A 10-Year Single Center Experience
( Hyang Suk You ),( Gun Wook Kim ),( Won Jeong Kim ),( Je Ho Mun ),( Margaret Song ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Byung Soo Kim ),( Moon Bum Kim ) 대한피부과학회 2016 Annals of Dermatology Vol.28 No.1
Background: A variety of infectious, inflammatory, and neoplastic dermatoses can develop on the glans penis, and definitive diagnosis in such cases may be difficult owing to their non-specific symptoms and clinical appearance. Furthermore, data on dermatoses of the glans penis in Korea are limited. Objective: In the present study, we aimed to determine the prevalence of dermatoses of the glans penis in Korea and provide clinical data to assist in making an accurate diagnosis. Methods: We retrospectively reviewed the medical records, clinical photographs, and histologic slides of 65 patients with dermatoses of the glans penis that visited the Pusan National University Hospital between January 2004 and August 2013. Results: Twenty-six types of dermatoses were identified: inflammatory dermatosis was the most common (38/65, 58. 5%), followed by infectious (13/65, 20. 0%), neoplastic (10/65, 15. 4%), and other dermatoses (4/65, 6. 2%). The most common dermatosis of the glans penis was seborrheic dermatitis, followed by lichen planus, herpes progenitalis, condyloma accuminatum, erythroplasia of Queyrat, Zoon s balanitis, and psoriasis. In the topographic analysis, the most common type of dermatosis was dermatoses that localized to the glans penis (39/65, 60. 0%), followed by dermatoses involving the extra-genitalia and glans penis (22/65, 33. 9%), and the genitalia (glans penis plus other genital areas) (4/65, 6. 2%). Conclusion: This study shows the usefulness of a topographic approach in the diagnosis of dermatoses of the glans penis in Korea. The findings could be used as baseline data for establishing an accurate diagnosis in Koreans.
Effectiveness of Specific Sublingual Immunotherapy in Korean Patients with Atopic Dermatitis
( Hyang-suk You ),( Min-young Yang ),( Gun-wook Kim ),( Hyun-ho Cho ),( Won-jeong Kim ),( Je-ho Mun ),( Margaret Song ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Moon-bum Kim ),( Byung-soo Kim ) 대한피부과학회 2017 Annals of Dermatology Vol.29 No.1
Background: Sublingual immunotherapy (SLIT) with house dust mites (HDM) preparation has recently been proven to be beneficial for treating allergic rhinitis and asthma. However, there has been no report regarding the efficacy and safety of SLIT in Korean patients with atopic dermatitis (AD). Objective: We intended to investigate the efficacy and safety of SLIT in Korean patients with AD. Methods: A total of 34 patients with AD and immunoglobulin E (IgE)-proven HDM sensitization (Class ≥3) were recruited. Eczema area and severity index (EASI) score, total serum IgE level, specific IgE assays to Dermatophagoides pteronyssinus, D. farinae, and adverse effects were recorded during follow-up. “Responder” was defined as a patient with ≥30% improvement in EASI score after SLIT. Results: Twenty-three patients continued SLIT for 12 months or more, whereas 3 patients (8.8%) dropped out because of exacerbation of dermatitis, and 8 patients (23.5%) were lost to follow-up. The average duration of SLIT treatment was 22.4 months (range, 12∼32 months). EASI scores reduced significantly after 6 months of treatment (p <0.05) compared with those at baseline. A total of 18 patients were determined to be responders to SLIT after 6 months. Total and specific IgE serum levels did not significantly reduce after SLIT. No patients experienced serious adverse events, with the exception of two patients who developed transient lip and tongue swelling. Conclusion: Our study demonstrated that SLIT with HDM extracts is effective and tolerable in Korean patients with AD. Further controlled long-term trials are required to reinforce the current results. (Ann Dermatol 29(1) 1∼5, 2017)
( Hyang Suk You ),( Gun Wook Kim ),( Hyun Ho Cho ),( Won Jeong Kim ),( Je Ho Mun ),( Margaret Song ),( Hoon Soo Kim ),( Hyun Chang Ko ),( Moon Bum Kim ),( Seung Geun Lee ),( In Sook Lee ),( Byung Soo 대한피부과학회 2015 Annals of Dermatology Vol.27 No.3
Background: Psoriatic arthritis (PsA) is chronic seronegative inflammatory arthritis that causes irreversible joint damage. Early recognition of PsA in patients with psoriasis is important for preventing physical disability and deformity. However, diagnosing PsA in a busy dermatology outpatient clinic can be difficult. Objective: This study aimed to validate the Psoriatic Arthritis Screening and Evaluation (PASE) questionnaire for the detection of PsA in Korean patients with psoriasis. Methods: The PASE questionnaire was prospectively given to 148 patients diagnosed with psoriasis but without a previous diagnosis of PsA. All patients underwent radiologic and laboratory examinations, and a subsequent clinical evaluation by a rheumatologist. Results: Eighteen psoriasis patients (12.2%) were diagnosed with PsA according to the Classification Criteria for Psoriatic Arthritis. The PASE questionnaire scores of differed significantly between PsA and non-PsA patients. Receiver operator characteristic analysis showed an area under the curve of 0.82 (95% confidence interval: 0.72, 0.92) for PASE score. A PASE score cut-off of 37 points had a sensitivity of 77.8% and specificity of 82.3% for the diagnosis of PsA. Conclusion: The PASE questionnaire is a simple and convenient screening tool for detecting PsA in Korean dermatology clinics. A PASE questionnaire score of 37 points appears to be an appropriate cut-off for screening Korean psoriasis patients. (Ann Dermatol 27(3) 265∼268, 2015)