Current-Type Nine-Switch Inverters

Dehghan, Seyed Mohammad,Mohamadian, Mustafa,Yazdian, Ali The Korean Institute of Power Electronics 2010 JOURNAL OF POWER ELECTRONICS Vol.10 No.2

In this paper two dual output current-type inverters are proposed. These inverters have been called a current source nines-witch inverter and a current-type z-source nine-switch inverter by the authors. The proposed inverters have two independent current source outputs. Compared to two independent current source inverters, the proposed converters are implemented with fewer semiconductor switches. Space vector modulation (SVM) is proposed for these converters. Simulation results show the validity and performance of the proposed inverters.

Dendrosomal Curcumin Inhibits Metastatic Potential of Human SW480 Colon Cancer Cells through Down-regulation of Claudin1, Zeb1 and Hef1-1 Gene Expression

Esmatabadi, Mohammad Javad Dehghan,Farhangi, Baharak,Safari, Zahra,Kazerooni, Hanif,Shirzad, Hadi,Zolghadr, Fatemeh,Sadeghizadeh, Majid Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.6

Colon cancer is one of the leading causes of cancer-associated death worldwide. The prognosis for advanced colorectal cancers remains dismal, mainly due to the propensity for metastatic progression. Accordingly, there is a need for effective anti-metastasis therapeutic agents. Since a great body of research has indicated anticancer effects for curcumin, we investigated the effects of dendrosomal curcumin (DNC) on cellular migration and adhesion of human SW480 cells and possible molecular mechanisms involved. Different methods were applied in this study including MTT, Scratch and adhesion assays as well as real-time PCR and transwell chamber assays. Based on the results obtained, DNC inhibits metastasis by decreasing Hef 1, Zeb 1 and Claudin 1 mRNA levels and can reduce SW480 cell proliferation with $IC_{50}$values of 15.9, 11.6 and $7.64{\mu}M$ at 24, 48 and 72h post-treatment. Thus it might be considered as a safe formulation for therapeutic purpose in colorectal cancer cases.

Techniques for Evaluation of LAMP Amplicons and their Applications in Molecular Biology

Esmatabadi, Mohammad javad Dehghan,Bozorgmehr, Ali,zadeh, Hesam Motaleb,Bodaghabadi, Narges,Farhangi, Baharak,Babashah, Sadegh,Sadeghizadeh, Majid Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.17

Loop-mediated isothermal amplification (LAMP) developed by Notomi et al. (2000) has made it possible to amplify DNA with high specificity, efficiency and rapidity under isothermal conditions. The ultimate products of LAMP are stem-loop structures with several inverted repeats of the target sequence and cauliflower-like patterns with multiple loops shaped by annealing between every other inverted repeats of the amplified target in the similar strand. Because the amplification process in LAMP is achieved by using four to six distinct primers, it is expected to amplify the target region with high selectivity. However, evaluation of reaction accuracy or quantitative inspection make it necessary to append other procedures to scrutinize the amplified products. Hitherto, various techniques such as turbidity assessment in the reaction vessel, post-reaction agarose gel electrophoresis, use of intercalating fluorescent dyes, real-time turbidimetry, addition of cationic polymers to the reaction mixture, polyacrylamide gel-based microchambers, lateral flow dipsticks, fluorescence resonance energy transfer (FRET), enzyme-linked immunosorbent assays and nanoparticle-based colorimetric tests have been utilized for this purpose. In this paper, we reviewed the best-known techniques for evaluation of LAMP amplicons and their applications in molecular biology beside their advantages and deficiencies. Regarding the properties of each technique, the development of innovative prompt, cost-effective and precise molecular detection methods for application in the broad field of cancer research may be feasible.

Current-Type Nine-Switch Inverters

Seyed Mohammad Dehghan,Mustafa Mohamadian,Ali Yazdian 전력전자학회 2010 JOURNAL OF POWER ELECTRONICS Vol.10 No.2

In this paper two dual output current-type inverters are proposed. These inverters have been called a current source nineswitch inverter and a current-type z-source nine-switch inverter by the authors. The proposed inverters have two independent current source outputs. Compared to two independent current source inverters, the proposed converters are implemented with fewer semiconductor switches. Space vector modulation (SVM) is proposed for these converters. Simulation results show the validity and performance of the proposed inverters.

Experimental and numerical assessment of beam-column connection in steel moment-resisting frames with built-up double-I column

Seyed Mehdi Dehghan,Mohammad Amir Najafgholipour,Seyed Mohsen Ziarati,Mohammad Reza Mehrpour 국제구조공학회 2018 Steel and Composite Structures, An International J Vol.26 No.3

Built-up Double-I (BD-I) columns consist of two hot rolled IPE sections and two cover plates which are welded by fillet welds. In Iran, this type of column is commonly used in braced frames with simple connections and sometimes in low-rise Moment Resisting Frames (MRF) with Welded Flange Plate (WFP) beam-column detailing. To evaluate the seismic performance of WFP connection of I-beam to BD-I column, traditional and modified exterior MRF connections were tested subjected to cyclic prescribed loading of AISC. Test results indicate that the traditional connection does not achieve the intended behavior while the modified connection can moderately meet the requirements of MRF connection. The numerical models of the connections were developed in ABAQUS finite element software and validated with the test results. For this purpose, moment-rotation curves and failure modes of the tested connections were compared with the simulation results. Moreover to avoid improper failure modes, some improvements of the connections were evaluated through a numerical study.

Green Synthesis of ZnO/αFe2O3 Nano-photocatalyst for Efficient Removal of Carbamate Pesticides in Wastewater: Optimization, Mineralization, and Financial Analysis

Dehghan Ali,Aliasghar Arash,Rahmati Roxana,Delnavaz Mohammad,Khoshvaght Hoda 한국화학공학회 2024 Korean Journal of Chemical Engineering Vol.41 No.1

As emerging organic agricultural pollutants, carbamate pesticides can react with other contaminants in aquatic environments to produce new toxic compounds threatening aquatic life and ecosystems. This study introduces a novel, nonhazardous, and greener method to synthesize a cross-linked ZnO/αFe 2 O 3 nano-photocatalyst to treat carbamate pesticides via ball milling. ZnO/αFe 2 O 3 was characterized through various methods, including XRD, EDX, XRF, DRS, BET, FE-SEM, PL, and FTIR analyses. Using the Response Surface Methodology (RSM), the ability of ZnO/αFe 2 O 3 nano-photocatalyst to remove carbamate from synthesized wastewater was assessed. The BET result indicated a decrease in the diameter of the nanocomposite size after the synthesis. At the same time, the BET surface area and total pores increased from 4.9871 m 2 .g −1 and 0.02806 cm 3 .g −1 to 6.8524 m 2 .g −1 and 0.069497 cm 3 .g −1 , respectively. In addition, the band-gap energy decreased from 3.179 eV for ZnO to 1.907 eV for ZnO/αFe 2 O 3 and eventually reached 1.878 eV for heat-treated ZnO/αFe 2 O 3 nanocomposite. The catalyst concentrations used in the experiments were 0.5, 1, and 1.5 g/L. The solution pH was set to 5, 8, and 11, and three diff erent residence times of 1, 2, and 3 h were used. The model’s results indicated a strong agreement between the experimental and predicted data (R 2 = 0.99). When the nanocomposite’s concentration, pH, and retention time were set at 1 g/L ZnO/αFe 2 O 3 , 8.51, and 3 h respectively, the optimized conditions predicted a removal effi ciency of 89%. In addition, the cost of COD removal was reduced by 50% using ball milling and heat-treatment synthesis. The photocatalyst’s reusability was tested in three stages, and the outcomes demonstrated its stability throughout these three stages.

Removal of methylene blue dye from aqueous solutions by a new chitosan/zeolite composite from shrimp waste: Kinetic and equilibrium study

Mohammad Hadi Dehghani,Aliakbar Dehghan,Hossein Alidadi,Maryam Dolatabadi,Marjan Mehrabpour,Attilio Converti 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.6

The adsorption of methylene blue dye (MBD) from aqueous solutions was investigated using a new composite made up of shrimp waste chitosan and zeolite as adsorbent. Response surface methodology (RSM) was used to optimize the effects of process variables, such as contact time, pH, adsorbent dose and initial MBD concentration on dye removal. The results showed that optimum conditions for removal of MBD were adsorbent dose of 2.5 g/L and pH of 9.0, and initial MBD concentration of 43.75mg/L and contact time of 138.65 min. The initial concentration of dye had the greatest influence on MBD adsorption among other variables. The experimental data were well fitted by the pseudo-second order kinetic model, while the Freundlich isotherm model indicated a good ability for describing equilibrium data. According to this isotherm model, maximum adsorption capacity of the composite was 24.5mg/g. Desorption studies showed that the desorption process is favored at low pH under acidic conditions.

Removing Reactive Red 120 and 196 using chitosan/zeolite composite from aqueous solutions: Kinetics, isotherms, and process optimization

Mohammad Hadi Dehghani,Aliakbar Dehghan,Aliasghar Najafpoor 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.51 No.-

A low-cost adsorptive composite was prepared using natural zeolite, clinoptilolite, and shrimp shellwastes as raw materials. The shrimp waste was used to synthesize chitosan by the deacetylation of chitinwhich was extracted from the exoskeleton of crustacean shrimps. Response surface methodology (RSM)was employed to model and optimize the effect of process variables including initial dye concentration(25–100 mg/L), solution pH (3–11), adsorbent dose (1–3 g/L), and contact time (15–180 min) on thepercentage of dye removal as the response. The optimum levels of independent variables for the removalof Reactive Red 120 (RR120) were time of 138.75 min, initial concentration of 43.79 mg/L, adsorbent doseof 2 g/L, and pH of 5. The optimum values for the removal of Reactive Red 196 (RR196) were time of125.77 min, initial concentration of 44.72 mg/L, adsorbent dose of 2.5 g/L, and pH of 5. Under optimalconditions, the predicted removal percent of the model was 91.2 and 100% for RR120 and RR196,respectively. The results showed that the experimental data of RR120 were better described by Hill andSips isotherms, and experimental data of RR196 followed Jovanovic isotherm model. The pseudo-firstorderand pseudo-second-order models were employed to analyze the kinetic data. The kinetic data werewell described by pseudo-second-order model with R2Adjvalues of higher than 0.98 and 0.99 forRR120 and RR196, respectively. The results showed that all of the independent variables exhibited asignificant effect on dye removal.

The TP53 intron 6 G13964C Polymorphism and Risk of Thyroid and Breast Cancer Development in the Iranian Azeri Population

Dehghan, Roghayeh,Feizi, Mohammad Ali Hosseinpour,Pouladi, Nasser,Adampourezare, Mina,Farajzadeh, Davoud Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.7

Background: TP53 mutations are the most common genetic alterations in human cancers. There are also several polymorphisms in both exons and introns of TP53 that may influence its anti-tumor functions and increase the risk of cancer development. Associations of the TP53 intron 6 G13964C polymorphism with increased risk of development of several cancers have been investigated in numerous studies, but the results were controversial and conflicting. In this study, we aimed to investigate the probable association of this polymorphism with risk of both thyroid and breast cancers among the Iranian-Azeri population. Materials and Methods: We performed two separate case control studies on associations of the intron 6 polymorphism with two different kinds of cancer. In one case-control study, a total of 75 patients with thyroid carcinoma and 180 controls were analyzed and the other study included 170 patients with breast cancer and 135 healthy women. The intron 6 genotype was determined by RFLP-PCR and the SPSS 16 program was applied for data analysis. Results: For thyroid cancer, the frequencies of GG genotype were 96.0% in patients and 93.3% in controls. The GC genotype had a frequency of 4.0 % in patients and 6.7% in controls. In the study on breast cancer, the frequency of GG and GC genotypes in patients were 95.3% and 4.7%, respectively. In breast related control group, the frequency of GG genotype was 93.3 % and the frequency of GC genotype was 6.7%. None of the cases and controls had the CC genotype. Conclusions: There was no significant association between the TP53 intron 6 G13964C polymorphism and risk of development of both thyroid and breast cancer in Iranian-Azeri patients.

Comparison of mice’ sperm parameters exposed to some hazardous physical agents

Mohammad-Bagher Abdollahi,Somayeh Farhang Dehghan,Faezeh Abasi Balochkhaneh,Manouchehr Ahmadi Moghadam,Hamzeh Mohammadi 환경독성보건학회 2021 환경독성보건학회지 Vol.36 No.3

The present study was aimed to compare the effects of exposure to noise, vibration, lighting, and microwave on male mice’ sperm parameters. The mice were randomly assigned to five groups of eight, which comprised of the unexposed group and exposure groups including the lighting (1000 lux), noise (100 dB(A)), vibration (acceleration of 1.2 m/s²) and microwave (power density of 5 watts). The exposure groups were subjected to the four agents for 8 hours a day, 5 days a week during a 2-week period. Semen analysis were done according to World Health Organization guidelines. The highest significant mean difference in sperm count (-1.35×10<SUP>6</SUP>/mL) had being observed between the microwave group and the control one (P=0.001). The highest difference in immotile percent (25.88 %) had being observed between the noise group and the control one (P=0.001). The highest difference in normal morphology (-27.06 %) observed between the lighting exposure group and the control group (P=0.001). The four agents can cause changes in different sperm parameters, however for definite conclusion; more laboratory and field studies are required. In total, exposure to microwave has had the greatest effect on sperm count and exposure to light has had the greatest effect on normal morphology and non-progressive motility. Moreover, exposure to noise has had the greatest effect on progressive motility and immotile percent, respectively.