XRCC1 Gene Polymorphisms and Breast Cancer Risk: A Systematic Review and Meta-analysis Study

Moghaddam, Ali Sanjari,Nazarzadeh, Milad,Moghaddam, Hossein Sanjari,Bidel, Zeinab,Karamatinia, Aliasghar,Darvish, Hossein,Jarrahi, Alireza Mosavi Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.no.sup3

Breast cancer risk assessment has developed during years and evaluation of genetic factor affecting risk of breast cancer is an important component of this risk assessment. The aim of this meta-analysis was to investigate the role of XRCC1 polymorphisms (Arg194Trp, Arg280His and Arg399Gln) in risk of breast cancer among different population and categories of menopausal status.PubMed, Medline, Web of Science, and PubMed Central were systematically searched to identify studies evaluating association between breast cancer and XRCC1 gene polymorphisms (Arg194Trp, Arg280His and Arg399Gln). Two authors independently extracted required information. Odds Ratios were pooled for four genetic inheritance models using both fixed and the DerSimonian and Laird random-effect models. Egger's test and contour-enhanced funnel plot was used to evaluate publication bias and small study effect. Additional subgroup analysis was performed for menopausal status, ethnicity, and source of controls. After evaluation and applying inclusion criteria on extracted studies, fifty three studies were included in this meta-analysis. For polymorphisms of Arg194Trp and Arg280His, no significant association was observed in all genetic models. Arg194Trp had a protective effect in post-menopausal status only in homozygote model (OR=0.57 [0.37-0.88]). Arg399Gln showed significant association with breast cancer in homozygote (OR=1.21 [1.10-1.34]), dominant (OR=1.09 [1.03-1.15]) and recessive (OR=1.21 [1.09- 1.35]) genetic models. Arg399Gln was associated with higher risk in post-menopausal status for homozygote and heterozygote models. Our findings suggest that XRCC1 gene polymorphisms modify breast cancer risk in different populations and different categories of menopausal status.

Immunological Responses of Broiler Chicks Can Be Modulated by Dietary Supplementation of Zinc-methionine in Place of Inorganic Zinc Sources

Moghaddam, Hasan Nassiri,Jahanian, Rahman Asian Australasian Association of Animal Productio 2009 Animal Bioscience Vol.22 No.3

Male broiler chicks were fed graded levels of organic zinc (zinc-methionine) supplementation to investigate the effects of partial or complete substitution of the organic zinc source for inorganic ones on the development of lymphoid organs and immunological responses. A total of 450 day-old male broilers were distributed into groups of 10 chicks and randomly assigned to nine experimental diets during a 42-day feeding trial. Dietary treatments consisted of two basal diets supplemented with 40 mg/kg added zinc as feed-grade Zn sulfate or Zn oxide in which, Zn was replaced with that provided from zinc-methionine (ZnMet) complex at the levels of 25, 50, 75 or 100%. Two randomly-selected birds from each pen replicate were bled and then slaughtered by cervical cutting on the final day of the trial to measure leukocyte subpopulations and relative weights of lymphoid organs. Among lymphoid organs, only thymus weight was affected (p<0.05) by dietary treatments. The sulfate-supplemented birds were heavier (p<0.01) in relative weight of thymus than oxide-supplemented birds. The 10 days of age-assessed cutaneous hypersensivity reaction was stronger in chicks fed ZnMet-containing diets. Dietary ZnMet supplementation caused (p<0.05) an increase in proportion of lymphocytes and consequently a decrease in heterophil to lymphocyte ratio. Diet fortification by zinc-methionine complex increased (p<0.01) Newcastle antibody titer at 19 days of age. Also, a similar response was observed in antibody titers at 6 and 12 d after infectious bronchitis vaccine administration. There was no significant effect of replacement of dietary zinc on antibody titer against infectious bursal disease virus (IBDV) at the 6th d post-vaccine inoculation; however, at d 12 after vaccination, ZnMet-fortified diets improved antibody titer against IBDV. Although dietary inclusion of ZnMet had no marked effect on primary antibody titer against sheep erythrocytes, effective responses were observed during secondary reaction from the viewpoint of both total antibody and immunoglobulin Y (IgY) titers. From the present findings, it can be concluded that dietary supplementation with organic zinc improves both cellular and humoral immune responses. It is necessary to replace 75% of supplemental inorganic zinc with organic ZnMet complex to achieve the optimum immunological responses in broiler chicks.

Simplified Failure Mechanism for the Prediction of Tunnel Crown and Excavation Front Displacements

Moghaddam, Rozbeh B.,Kim, Mintae Korean Tunnelling and Underground Space Associatio 2019 자연, 터널 그리고 지하공간 Vol.21 No.1

This case study presented a simplified failure mechanism approach used as a preliminary deformation prediction for the Mexico City's metro system expansion. Because of the Mexico City's difficult subsoils, Line 12 project was considered one of the most challenging projects in Mexico. Mexico City's subsurface conditions can be described as a multilayered stratigraphy changing from soft high plastic clays to dense to very dense cemented sands. The Line 12 trajectory crossed all three main geotechnical Zones in Mexico City. Starting from to west of the City, Line 12 was projected to pass through very dense cemented sands corresponding to the Foothills zone changing to the Transition zone and finalizing in the Lake zone. Due to the change in the subsurface conditions, different constructions methods were implemented including the use of TBM (Tunnel Boring Machine), the NATM (New Austrian Tunneling Method), and cut-and-cover using braced Diaphragm walls for the underground section of the project. Preliminary crown and excavation front deformations were determined using a simplified failure mechanism prior to performing finite element modeling and analysis. Results showed corresponding deformations for the crown and the excavation front to be 3.5cm (1.4in) and 6cm (2.4in), respectively. Considering the complexity of Mexico City's difficult subsoil formation, construction method selection becomes a challenge to overcome. The use of a preliminary results in order to have a notion of possible deformations prior to advanced modeling and analysis could be beneficial and helpful to select possible construction procedures.

2-ENGELIZER SUBGROUP OF A 2-ENGEL TRANSITIVE GROUPS

Moghaddam, Mohammad Reza R.,Rostamyari, Mohammad Amin Korean Mathematical Society 2016 대한수학회보 Vol.53 No.3

A general notion of ${\chi}$-transitive groups was introduced by C. Delizia et al. in [6], where ${\chi}$ is a class of groups. In [5], Ciobanu, Fine and Rosenberger studied the relationship among the notions of conjugately separated abelian, commutative transitive and fully residually ${\chi}$-groups. In this article we study the concept of 2-Engel transitive groups and among other results, its relationship with conjugately separated 2-Engel and fully residually ${\chi}$-groups are established. We also introduce the notion of 2-Engelizer of the element x in G and denote the set of all 2-Engelizers in G by $E^2(G)$. Then we construct the possible values of ${\mid}E^2(G){\mid}$.

The Combining Ability Analysis and Heterosis for some Quanitatives Traits in the Silkworm (Bombyx mori L.)

Moghaddam S. H. Hosseini,Etebari K. Korean Society of Sericultural Science 2005 International Journal of Industrial Entomology Vol.10 No.2

Recently two breeding programs were carried out for isolation of new parental inbred lines in Iran. This study was undertaken in order to estimate the combining ability effects and heterosis of these lines. For this purpose an $8\times8$ diallel cross analysis including eight inbred lines of silkworm with four lines from each program were studied for their five quantitative traits. The results indicated that reciprocal effects appeared insignificant for most of traits. Japanese lines of 111 and 113 were best combiners for shell weight, cocoon weight and shell percentage traits. With respect to pupation rate, Chinese line 110 was the best and according to general combining ability (GCA) and specific combining ability (SCA) variances, it is superior in specific combinations. Hybrid $109\times110$ showed better characters for both productive and viability traits. Hybrids with high heterosis had high SCA too.

THE LOWER AUTOCENTRAL SERIES OF ABELIAN GROUPS

Moghaddam, Mohammad Reza R.,Parvaneh, Foroud,Naghshineh, Mohammad Korean Mathematical Society 2011 대한수학회보 Vol.48 No.1

In the present paper we introduce the lower autocentral series of autocommutator subgroups of a given group. Following our previous work on the subject in 2009, it is shown that every finite abelian group is isomorphic with $n^{th}$-term of the lower autocentral series of some finite abelian group.

SOME PROPERTIES OF TENSOR CENTRE OF GROUPS

Moghaddam, Mohammad Reza R.,Niroomand, Payman,Jafari, S. Hadi Korean Mathematical Society 2009 대한수학회지 Vol.46 No.2

Let $G{\otimes}G$ be the tensor square of a group G. The set of all elements a in G such that $a{\otimes}g\;=\;1_{\otimes}$, for all g in G, is called the tensor centre of G and denoted by $Z^{\otimes}^$(G). In this paper some properties of the tensor centre of G are obtained and the capability of the pair of groups (G, G') is determined. Finally, the structure of $J_2$(G) will be described, where $J_2$(G) is the kernel of the map $\kappa$ : $G{\otimes}\;{\rightarrow}\;G'$.

Optimization of ground response analysis using wavelet-based transfer function technique

Moghaddam, Amir Bazrafshan,Bagheripour, Mohammad H. Techno-Press 2014 Geomechanics & engineering Vol.7 No.2

One of the most advanced classes of techniques for ground response analysis is based on the use of Transfer Functions. They represent the ratio of Fourier spectrum of amplitude motion at the free surface to the corresponding spectrum of the bedrock motion and they are applied in frequency domain usually by FFT method. However, Fourier spectrum only shows the dominant frequency in each time step and is unable to represent all frequency contents in every time step and this drawback leads to inaccurate results. In this research, this process is optimized by decomposing the input motion into different frequency sub-bands using Wavelet Multi-level Decomposition. Each component is then processed with transfer Function relating to the corresponding component frequency. Taking inverse FFT from all components, the ground motion can be recovered by summing up the results. The nonlinear behavior is approximated using an iterative procedure with nonlinear soil properties. The results of this procedure show better accuracy with respect to field observations than does the Conventional method. The proposed method can also be applied to other engineering disciplines with similar procedure.

AUTOCOMMUTATORS AND AUTO-BELL GROUPS

Moghaddam, Mohammad Reza R.,Safa, Hesam,Mousavi, Azam K. Korean Mathematical Society 2014 대한수학회보 Vol.51 No.4

Let x be an element of a group G and be an automorphism of G. Then for a positive integer n, the autocommutator $[x,_n{\alpha}]$ is defined inductively by $[x,{\alpha}]=x^{-1}x^{\alpha}=x^{-1}{\alpha}(x)$ and $[x,_{n+1}{\alpha}]=[[x,_n{\alpha}],{\alpha}]$. We call the group G to be n-auto-Engel if $[x,_n{\alpha}]=[{\alpha},_nx]=1$ for all $x{\in}G$ and every ${\alpha}{\in}Aut(G)$, where $[{\alpha},x]=[x,{\alpha}]^{-1}$. Also, for any integer $n{\neq}0$, 1, a group G is called an n-auto-Bell group when $[x^n,{\alpha}]=[x,{\alpha}^n]$ for every $x{\in}G$ and each ${\alpha}{\in}Aut(G)$. In this paper, we investigate the properties of such groups and show that if G is an n-auto-Bell group, then the factor group $G/L_3(G)$ has finite exponent dividing 2n(n-1), where $L_3(G)$ is the third term of the upper autocentral series of G. Also, we give some examples and results about n-auto-Bell abelian groups.

Influence of climatic factors on essential oil content and composition of 20 populations of Nepeta binaludensis Jamzad from Iran

Moghaddam Hosien Hashemi,Jafari Ali Ashraf,Sefidkon Fatemeh,Jari Sepideh Kalate 한국응용생명화학회 2023 Applied Biological Chemistry (Appl Biol Chem) Vol.66 No.-

Nepeta binaludensis Jamzad is an endemic and rare perennial plant belonging to the Lamiaceae family, which grows in a limited area in Binaloud Mountain in northeast of Iran. In this study to evaluate the diversity of 20 populations (localities) of N. binaludensis and the influence of environmental factors on essential oil (EO) content and composition, the plant aerial parts were collected at the full flowering stage. The plant materials dried in shade and subjected to hydro-distillation for obtaining their EOs. Analysis of the EO was carried out using GC and GC/MS. The oil yields were varied from 1.2 to 4.9%. Classification of populations was made based on EO compounds. The results of mean comparison between populations belong to different habitats showed that the populations of Darood and Friezy with average values of 4.91 and 1.2% had the highest and lowest EO yield, respectively. Twenty-two compounds were identified in the oils with 1,8-cineol (25.4–59.0%), 4aα,7α,7aα-nepetalactone (13.8–55.1%), myrcene (2.3–5.5%) and p-cymene (1.1–5.7%) as the main components. Result of correlation analysis showed that the oil yield was positively correlated with precipitation and negatively with temperature. In addition, 1,8-cineole was positively and nepetalactone was negatively correlated with altitude. Cluster analysis by Ward method categorized the populations into two groups. The major compound of the oils in cluster 1 was nepetalactone (with an average of 37.9%), while the oils in cluster 2, contained higher percentage of 1,8-cineole (52–59%). Most of the populations in cluster 2, were originated from high, cold, rainy, and steep areas.