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RISS 인기검색어
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- 저자 : Miriam Kleiter (검색결과 2 건)
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Elevated fructosamine concentrations caused by IgA paraproteinemia in two dogs
Florian Zeugswetter,Miriam Kleiter,Birgitt Wolfesberger,Ilse Schwendenwein,Ingrid Miller 대한수의학회 2010 JOURNAL OF VETERINARY SCIENCE Vol.11 No.4
An 8-year-old male Austrian Pinscher and a 14-year-old male Golden Retriever were presented for evaluation due to unexplainable high fructosamine values despite euglycemia and epistaxis in combination with polydipsia/polyuria, respectively. Blood analysis revealed severe hyperglobulinemia, hypoalbuminemia and markedly elevated fructosamine concentrations in both dogs. Multiple myeloma with IgAmonoclonal gammopathy was diagnosed by serum and urine electrophoresis including immunodetection with an anti-dog IgA antibody and bone marrow aspirations. Diabetes mellitus was excluded by repeated plasma and urine glucose measurements. Fructosamine values were positively correlated with globulin, but negatively correlated with albumin concentrations. These cases suggest that, as in human patients, monoclonal IgA gammopathy should be considered as a possible differential diagnosis for dogs with high fructosamine concentrations.
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Radiation up-regulates the expression of VEGF in a canine oral melanoma cell line
Irene Flickinger,Barbara C Rütgen,Wilhelm Gerner,Ivana Calice,Alexander Tichy,Armin Saalmüller,Miriam Kleiter 대한수의학회 2013 JOURNAL OF VETERINARY SCIENCE Vol.14 No.2
To evaluate radiosensitivity and the effects of radiation on the expression of vascular endothelial growth factor (VEGF) and VEGF receptors in the canine oral melanoma cell line, TLM 1,cells were irradiated with doses of 0, 2, 4, 6, 8 and 10 Gray (Gy). Survival rates were then determined by a MTT assay, while vascular endothelial growth factor receptor (VEGFR)-1 and -2expression was measured by flow cytometry and apoptotic cell death rates were investigated using an Annexin assay. Additionally, a commercially available canine VEGF ELISA kit was used to measure VEGF. Radiosensitivity was detected in TLM 1 cells, and mitotic and apoptotic cell death was found to occur in a radiation dose dependent manner. VEGF was secreted constitutively and significant up-regulation was observed in the 8 and 10 Gy irradiated cells. In addition, a minor portion of TLM 1 cells expressed vascular endothelial growth factor receptor (VEGFR)-1 intracellularly. VEGFR-2was detected in the cytoplasm and was down-regulated following radiation with increasing dosages. In TLM 1 cells,apoptosis plays an important role in radiation induced cell death. It has also been suggested that the significantly higher VEGF production in the 8 and 10 Gy group could lead to tumour resistance.
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