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Mika Seto,Michitaka Matsuda,Kyoichi Narihira,Toshihiro Kikuta 대한구강악안면외과학회 2016 대한구강악안면외과학회지 Vol.42 No.3
We report a case of a morbidly obese man with an aortic aneurysm, in whom dental surgery was performed before elective cardiac surgery. His aortic aneurysm required emergency surgery. However, because of his morbid obesity, elective cardiac surgery was planned. Considering the high risk of infective endocarditis, dental surgery was required. Our patient was at a high risk of aortic rupture caused by hypertension and breathing difficulty in the supine position. Dexmedetomidine (DEX) is an anti-anxiety, sedative, and analgesic medicine that can stabilize circulatory dynamics and minimize blood pressure fluctuations. We administered intravenous DEX for sedation of the patient in Fowler’s position. In conclusion, our understanding of the risk factors of DEX enabled us to perform safe invasive oral treatment.
Yoon Mee Yang,Zhijun Wang,Michitaka Matsuda,Ekihiro Seki 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.2
Hyaluronan (HA) as a glycosaminoglycan canbind to cell-surface receptors, such as TLR4, to regulateinfl ammation, tissue injury, repair, and fi brosis. 4-methylumbelliferone(4-MU), an inhibitor of HA synthesis, is adrug used for the treatment of biliary spasms. Currently,therapeutic interventions are not available for non-alcoholicsteatohepatitis (NASH). In this study, we investigated theeff ects of 4-MU on NASH using a choline-defi cient aminoacid (CDAA) diet model. CDAA diet-fed mice showedNASH characteristics, including hepatocyte injury, hepaticsteatosis, infl ammation, and fi brogenesis. 4-MU treatmentsignifi cantly reduced hepatic lipid contents in CDAA dietfedmice. 4-MU reversed CDAA diet-mediated inhibitionof Ppara and induction of Srebf1 and Slc27a2 . Analysis ofserum ALT and AST levels revealed that 4-MU treatmentprotected against hepatocellular damage induced by CDAAdiet feeding. TLR4 regulates low molecular weight-HAinducedchemokine expression in hepatocytes. In CDAAdiet-fed, 4-MU-treated mice, the upregulated chemokine/cytokine expression, such as Cxcl1 , Cxcl2 , and Tnf wasattenuated with the decrease of macrophage infi ltration intothe liver. Moreover, HA inhibition repressed CDAA dietinducedmRNA expression of fi brogenic genes, Notch1 , and Hes1 in the liver. In conclusion, 4-MU treatment inhibitedliver steatosis and steatohepatitis in a mouse model ofNASH, implicating that 4-MU may have therapeutic potentialfor NASH.