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An Evaluation of Assessing the Functional Movement Screen™ from Video Playback
Matthew D Portas,Daniel Meek,Warren Gregson,Barry Drust 한국코칭능력개발원 2015 International Journal of Coaching Science Vol.9 No.2
The study aimed to evaluate the method comparison and intra-rater test-retest reliability of the Functional Movement Screen when assessed by real-time and video playback. Eighteen participants (Age: 22 ± 2 years, Height: 1.77 m ± 0.10 m, Weight: 78.2 ± 11.5 kg, 15 males and 3 females), participated. Participants were scored during the screen in real-time by an experienced coach. Each screen was also video recorded in the frontal and sagittal plane. The coach then scored each FMS via video, in a randomised order, 3 days (video-1) and 7 days later (video-2). Median and interquartile range were calculated for the group score in each assessment. The weighted kappa statistic, percentage of agreement and bias were then calculated for each FMS test.. The median (interquartile ranges) for the group FMS score was 16.0 (15.0 and 17.0) for the live assessment; 16 (14.0 and 17.0) for video-1 and 16 (13.8 and 17.0) for video-2. The mean (SD) agreement across all tests live compared to video was 87.4% (11.1) with a weighted kappa statistic of 0.9 (0.1) (almost perfect). These results provide guidance for the interchangeably of these techniques in practice and confirm the legitimacy of the approach for the previous work that used video to assess reliability of measurement.
Comprehensive Characterization of Cancer Driver Genes and Mutations
Bailey, Matthew H.,Tokheim, Collin,Porta-Pardo, Eduard,Sengupta, Sohini,Bertrand, Denis,Weerasinghe, Amila,Colaprico, Antonio,Wendl, Michael C.,Kim, Jaegil,Reardon, Brendan,Kwok-Shing Ng, Patrick,Jeon Elsevier 2018 Cell Vol.174 No.4
Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics
Ding, Li,Bailey, Matthew H.,Porta-Pardo, Eduard,Thorsson, Vesteinn,Colaprico, Antonio,Bertrand, Denis,Gibbs, David L.,Weerasinghe, Amila,Huang, Kuan-lin,Tokheim, Collin,Corté,s-Ciriano, Isidro,J Elsevier 2018 Cell Vol.173 No.2
<P><B>Summary</B></P> <P>The Cancer Genome Atlas (TCGA) has catalyzed systematic characterization of diverse genomic alterations underlying human cancers. At this historic junction marking the completion of genomic characterization of over 11,000 tumors from 33 cancer types, we present our current understanding of the molecular processes governing oncogenesis. We illustrate our insights into cancer through synthesis of the findings of the TCGA PanCancer Atlas project on three facets of oncogenesis: (1) somatic driver mutations, germline pathogenic variants, and their interactions in the tumor; (2) the influence of the tumor genome and epigenome on transcriptome and proteome; and (3) the relationship between tumor and the microenvironment, including implications for drugs targeting driver events and immunotherapies. These results will anchor future characterization of rare and common tumor types, primary and relapsed tumors, and cancers across ancestry groups and will guide the deployment of clinical genomic sequencing.</P> <P><B>Highlights</B></P> <P> <UL> <LI> An overview of PanCancer Atlas analyses on oncogenic molecular processes </LI> <LI> Germline genome affects somatic genomic landscape in a pathway-dependent fashion </LI> <LI> Genome mutations impact expression, signaling, and multi-omic profiles </LI> <LI> Mutation burdens and drivers influence immune-cell composition in microenvironment </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>