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- 저자 : Massimo Giunti (검색결과 2 건)
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Massimo Giunti,Roberta Troia,Mara Battilani,Luciana Giardino,Francesco Dondi,Giulia Andreani,Federico Fracassi 대한수의학회 2017 Journal of Veterinary Science Vol.18 No.4
Critical illness can be associated with transient alterations in circulating thyroid hormone concentrations, indicating the presence of non-thyroidal illness (NTI). NTI is well described in humans, but there are few reports on its occurrence and prognostic significance in dogs. This retrospective study assessed the occurrence of NTI in a population of dogs with systemic inflammatory response syndrome (SIRS) and investigated its association with disease severity (APPLEfast scores). A total of 41 SIRS dogs were included and were divided by SIRS origin (non-septic SIRS, n = 10; septic SIRS, n = 41) and final outcome (survivors, n = 37; non-survivors, n = 4). Healthy, age-matched dogs (n = 15) were included as controls. Serum thyroid hormone levels including total T3, free T3, total T4, and reverse T3 were measured upon admission. Compared to controls, there were significant changes in serum thyroid hormone concentrations in SIRS dogs, suggesting the presence of NTI. Septic SIRS dogs had higher APPLEfast scores and lower serum thyroid hormones concentrations than those in non-septic SIRS and control dogs. In conclusion, NTI was frequent in dogs with SIRS and may be associated with the presence of sepsis or high illness severity.
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Francesca Bresciani,Marco Pietra,Sara Corradini,Massimo Giunti,Federico Fracassi 대한수의학회 2014 Journal of Veterinary Science Vol.15 No.2
In human medicine, diagnosis of diabetic ketoacidosis(DKA) is usually based on measurement of capillary3-β-hydroxybutyrate (3-HB) with a hand held ketonesensor. This study was conducted to determine ifmeasurement of capillary 3-HB could be useful for thediagnosis and monitoring of canine DKA. Fifteen dogs withdiabetic ketosis and 10 with DKA were evaluated. Pairedmeasurements of 3-HB of capillary and venous bloodsamples were analysed by the electrochemical sensor andreference method. Use of capillary 3-HB measurementduring DKA management was then evaluated throughsimultaneous measurements of capillary 3-HB, urinaryAcAc and venous blood gas analysis. Good agreementbetween capillary and venous 3-HB measurement wasdetected by the electrochemical sensor and referencemethod. Monitoring treatment of DKA revealed asignificant correlation between capillary 3-HB and acidosismarkers, while no significant correlation was observedbetween AcAc and acidosis markers. A cut-off value ofcapillary blood 3-HB >3.8 mmol/L for diagnosis of DKAresulted in 70% and 92% sensitivity and specificity. Theelectrochemical sensor accurately measures 3-HBconcentration in both capillary and venous blood samples, isaccurate in diagnosing canine DKA, and appears to reflectthe patient’s metabolic status during DKA treatment.
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