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RISS 인기검색어
- 검색키워드
- 저자 : Masoumeh Mehdipour (검색결과 2 건)
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The Relationship between Anger Expression and Its Indices and Oral Lichen Planus
Masoumeh Mehdipour,Ali Taghavi Zenouz,Alireza Farnam,Rana Attaran,Sara Farhang,Maryam Safarnavadeh,Narges Gholizadeh,Saranaz Azari-Marhabi 전남대학교 의과학연구소 2016 전남의대학술지 Vol.52 No.2
Oral lichen planus (OLP) is a common inflammatory disease with unknown etiology. Depression, stress and anxiety are psychological factors that their influence on the expressionof lichen planus by affecting the immune system’s function has been confirmed. There is a probable relationship between anger and OLP expression. Therefore,the present study aimed to evaluate the association of “anger” and OLP. In this descriptivestudy 95 subjects were included in 3 groups. A: patients with oral lichen planus,B: positive control, C: negative control. Anger and its indices were assessed by theState-Trait Anger Expression Inventory-2 (STAXI-2) questionnaire, and pain wasmeasured via the Visual Analogue Scale (VAS). The collected data were analyzed statisticallyusing SPSS 18 software. The lichen planus and positive control groups borehigher total anger index (AX index) values compared with the negative control. Comparing anger expression-in (AXI) among the lichen planus and negative controlgroups revealed higher grades in lichen planus group. Evaluating the pain severity index(VAS) data and anger indices in lichen planus group, Spearman’s Rank CorrelationTest revealed a significant correlation between TAngR (reactional anger traits) andpain severity. The findings of this study indicated that there was a significant correlationbetween anger control and suppression of lichen planus development. On the otherhand, the patients with more severe pain mostly expressed their anger physically. Based on the findings, we can make the claim that anger suppression and its control-in(gathering tension) may play a role in the development of lichen planus as a knownpsychosomatic disorders.
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Abbasi, Mehran Mesgari,Mehdipour, Masoumeh,Monfaredan, Amir,Jahanban-Esfahlan, Rana Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.16
Background: Oral carcinoma (OC) remains one of the most difficult malignancies to cure. Hesa-A is an Iranian herbal-marine compound that has shown promising anti-tumor properties against various human tumors. However, its mechanism of action remains to be addressed. The present study was conducted to evaluate the effect of two doses of Hesa-A on mRNA expression of erb$\backslash$b2 as a main prognosticator tumor marker for OC in an animal model. Materials and Methods: A total of 60 rats were randomly divided into 5 groups of 12 animals each. Rats in carcinoma groups received 0, 250 and 500mg/kg body weight doses of Hesa-A 3 times a day. The other two groups were considered as treated and untreated control groups. At the end of the experiment, animals were sacrificed and tongue tissues subjected to H and E staining and real time PCR. Results: Our results showed that compared to the control group, erb$\backslash$b2 was over-expressed ~ 30% in the carcinoma group. After treatment with 250mg/kg and 500mg/kg body weight of Hesa-A, erb$\backslash$b2 levels dropped by 24.1% and 3.4 % respectively compared to the control carcinoma group (p<0.01, p<0.0001). Moreover, there was a significant relation between erb$\backslash$b2 mRNA content and observed pathological changes in studied groups (p<0.05). Conclusions: These data provide insight into mechanism(s) by which Hesa-A may improve clinical outcome of oral carcinoma by affecting oncogene erb$\backslash$b2 expression and suggest Hesa-A as an effective chemotherapeutic agent in treatment of HER+tumors.
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