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        RA 123 s: Three metaphor-less Algorithms for Economic Load Dispatch Solution

        Manam Ravindra,Sangu Ravindra,Pamidi Lakshminarayana,Karri Manoz Kumar Reddy 대한전기학회 2022 Journal of Electrical Engineering & Technology Vol.17 No.2

        This paper presents Rao-1, Rao-2 and Rao-3 algorithms (RA-123) approach to elucidate Economic Load Dispatch (ELD) problem which has Ramp Rate (RRL), Valve Point Eff ect (VPE), Prohibited Zones of Operation (POZ), and losses of lines. Besides most of the algorithms which depend on algorithmic-specifi c parameters, the proposed algorithm is independent of algorithmic-specifi c parameters. The principle contribution of this paper is to minimize the total generation cost by satisfying several constraints such as generation limits, load demand, valve point loading eff ect, and transmission losses considering metaphor-less algorithms (RA-123). The objective with VPE is considered to improve the performance of ELD. This paper determines the performance of proposed RA-123 algorithms considering diff erent constraints on each test case system and compares them. To explore, ability of proposed optimization algorithms, these are implemented on test networks having 6, 40 and 110 unit systems and outcomes are compared with results attained by prior optimization algorithms. The evaluation of results shows ability and effi cacy of (RA-123) for solving ELD problem.

      • Concurrent Chemoradiation with Weekly Cisplatin for the Treatment of Head and Neck Cancers: an Institutional Study on Acute Toxicity and Response to Treatment

        Ghosh, Saptarshi,Rao, Pamidimukkala Brahmananda,Kumar, P Ravindra,Manam, Surendra Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.16

        Background: Concurrent chemoradiation with three weekly high dose cisplatin is the non-surgical standard of care for the treatment of locally advanced head and neck cancers. Although this treatment regime is efficacious, it has high acute toxicity, which leads not only to increased treatment cost, but also to increased overall treatment time. Hence, the current study was undertaken to evaluate the acute toxicity and tumor response in head and neck cancer patients treated with concurrent chemoradiation using $40mg/m^2$ weekly cisplatin, which has been our institutional practice. Materials and Methods: This single institution retrospective study included data for 287 head and neck cancer patients treated with concurrent chemoradiation from 2012 to 2014. Results: The mean age of the patients was 48.8 years. The most common site of involvement was oral cavity. Most of the study patients presented with advanced stage disease. The mean overall treatment time was 56.9 days. Some 67.2% had overall complete response to treatment as documented till 90 days from the start of treatment. According to the Radiation Therapy Oncology Group (RTOG) acute radiation morbidity scoring criteria, mucositis was seen in 95.1% of the patients. Dermatitis and emesis were observed in 81.9% and 98.6%, respectively. Regarding haematological toxicity, 48.8% and 29.6% suffered from anaemia and leukopenia, respectively, during treatment. Acute kidney injury was assessed using the Common Terminology Criteria for Adverse Events (CTCAE), and was found in 18.8% of the patients. Conclusions: Concurrent chemoradiotherapy with weekly cisplatin is an effective treatment regime for head and neck cancers with reasonable toxicity which can be used in developing countries, where cost of treatment is so important.

      • Weekly Cisplatin-Based Concurrent Chemoradiotherapy for Treatment of Locally Advanced Head and Neck Cancer: a Single Institution Study

        Ghosh, Saptarshi,Rao, Pamidimukkala Brahmananda,Kumar, P Ravindra,Manam, Surendra Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.16

        Background: The organ preservation approach of choice for the treatment of locally advanced head and neck cancers is concurrent chemoradiation with three weekly high doses of cisplatin. Although this is an efficacious treatment policy, it has high acute systemic and mucosal toxicities, which lead to frequent treatment breaks and increased overall treatment time. Hence, the current study was undertaken to evaluate the efficacy of concurrent chemoradiation using 40 mg/m2 weekly cisplatin. Materials and Methods: This is a single institutional retrospective study including the data of 266 locally advanced head and neck cancer patients who were treated with concurrent chemoradiation using 40 mg/m2 weekly cisplatin from January 2012 to January 2014. A p-value of < 0.05 was taken to be significant statistically for all purposes in the study. Results: The mean age of the study patients was 48.8 years. Some 36.1% of the patients had oral cavity primary tumors. The mean overall treatment time was 57.2 days. With a mean follow up of 15.2 months for all study patients and 17.5 months for survivors, 3 year local control, locoregional control and disease free survival were seen in 62.8%, 42.8% and 42.1% of the study patients. Primary tumor site, nodal stage of disease, AJCC stage of the disease and number of cycles of weekly cisplatin demonstrated statistically significant correlations with 3 year local control, locoregional control and disease free survival. Conclusions: Concurrent chemoradiotherapy with moderate dose weekly cisplatin is an efficacious treatment regime for locally advanced head and neck cancers with tolerable toxicity which can be used in developing countries with limited resources.

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