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The Near-infrared Tip of the Red Giant Branch. I. A Calibration in the Isolated Dwarf Galaxy IC 1613
Madore, Barry F.,Freedman, Wendy L.,Hatt, Dylan,Hoyt, Taylor J.,Monson, Andrew J.,Beaton, Rachael L.,Rich, Jeffrey A.,Jang, In Sung,Lee, Myung Gyoon,Scowcroft, Victoria,Seibert, Mark American Astronomical Society 2018 The Astrophysical journal Vol.858 No.1
Genes Involved in Interleukin-1 Receptor Type II Activities Are Associated With Asthmatic Phenotypes
Anne-Marie Madore,Vanessa T. Vaillancourt,Emmanuelle Bouzigon,Chloé Sarnowski,Florent Monier,Marie-Hélène Dizier,Florence Demenais,Catherine Laprise 대한천식알레르기학회 2016 Allergy, Asthma & Immunology Research Vol.8 No.5
Purpose: Interleukin-1 (IL-1) plays a key role in inflammation and immunity and its decoy receptor, IL-1R2, has been implicated in transcriptomic and genetic studies of asthma. Methods: Two large asthma family collections, the French-Canadian Saguenay—Lac-St-Jean (SLSJ) study and the French Epidemiological Study on the Genetics and Environment of Asthma (EGEA), were used to investigate the association of SNPs in 10 genes that modulate IL-1R2 activities with asthma, allergic asthma, and atopy. Gene-gene interactions were also tested. Results: One SNP in BACE2 was associated with allergic asthma in the SLSJ study and replicated in the EGEA study before statistical correction for multiple testing. Additionally, two SNPs in the MMP2 gene were replicated in both studies prior to statistical correction and reached significance in the combined analysis. Moreover, three gene-gene interactions also survived statistical correction in the combined analyses (BACE1-IL1RAP in asthma and allergic asthma and IL1R1-IL1RAP in atopy). Conclusions: Our results highlight the relevance of genes involved in the IL-1R2 activity in the context of asthma and asthma-related traits.
Protective effects of polyphenols against endocrine disrupting chemicals
Matthew P. Madore,Junichi R. Sakaki,Ock K. Chun 한국식품과학회 2022 Food Science and Biotechnology Vol.31 No.8
Endocrine disrupting chemicals (EDCs) are aheterogenous group of compounds dispersed throughout theenvironment that possess the ability to alter endocrine systemfunction. While there are numerous routes of exposureto EDCs, the predominant source of many of these compoundsis diet, largely due to their widespread use in foodcontact materials. In recent years, there has been a surgeof research aimed at assessing exposure to EDCs, identifyingtheir health implications, and developing approaches tominimize the risks they may entail. Due to their antioxidantand anti-infl ammatory potential, polyphenols have beenpurported to confer protection against EDC-induced healthdetriments. This review discusses the evidence pertaining todietary exposure to the two predominant EDCs, bisphenol Aand phthalates, in the United States, their associations withdiabetes, cancer, and cardiovascular disease outcomes, thepotential for polyphenols to mitigate their disease-promotingeff ects, gaps in knowledge, and recommendations for futureresearch.
Non-commutative geometry of the h-deformed quantum plane
Cho, S,Madore, J,Park, K S 경북대학교 위상수학 기하학연구센터 1999 硏究論文集 Vol.8 No.-
The h-deformed quantum plane is a counterpart of the q-deformed one in the set of quantum planes which are covariant under those quantum deformations of GL(2) which admit a central determinant. We have investigated the non-commutative geometry of the h-deformed quantum plane. There is a two-parameter family of torsion-free linear connections, a one-parameter sub-family of which are compatible with a skew-symmetric non-degenerate bilinear map. The skew-symmetric map resembles a symplectic 2-form and induces a metric. It is also shown that the extended h-deformed quantum plane is a non-commutative version of the Poincare´ half-plane, a surface of constant negative Gaussian curvature.
Hatt, Dylan,Freedman, Wendy L.,Madore, Barry F.,Beaton, Rachael L.,Hoyt, Taylor J.,Jang, In Sung,Lee, Myung Gyoon,Monson, Andrew J.,Rich, Jeffrey A.,Scowcroft, Victoria,Seibert, Mark American Astronomical Society 2018 The Astrophysical journal Vol.861 No.2
<P>The Carnegie-Chicago Hubble Program is undertaking a re-calibration of the extragalactic distance scale, using SNe Ia that are tied to Tip of the Red Giant Branch (TRGB) distances to local galaxies. We present here deep Hubble Space Telescope ACS/WFC imaging of the resolved stellar populations in the metal-poor halos of the SN. Ia-host galaxies NGC 4424, NGC 4526, and NGC 4536. These three Virgo constellation galaxies are prime targets for calibrating the extragalactic distance scale given their relative proximity in the local universe and their low line-of-sight reddenings. Anchoring the TRGB zero-point to the geometric distance to the Large Magellanic Cloud via detached eclipsing binaries, we measure extinction-corrected distance moduli of 31.00 +/- 0.03(stat) +/- 0.06(sys) mag, 30.98 +/- 0.03(stat) +/- 0.06(sys) mag, and 30.99 +/- 0.03(stat) +/- 0.06(sys) mag for NGC 4424, NGC 4526, and NGC 4536, respectively, or 15.8 +/- 0.2(stat) +/- 0.4(sys) Mpc, 15.7 +/- 0.2(stat) +/- 0.4(sys) Mpc, and 15.8. +/-. 0.2stat. +/-. 0.4sys Mpc. For these three galaxies, the distances are the first that are based on the TRGB, and for NGC 4424 and NGC 4526, they are the highest-precision distances published to date, each measured to 3%. Finally, we report good agreement between our TRGB distances and the available Cepheid distances for NGC 4424 and NGC 4536, demonstrating consistency between the distance scales currently derived from stars of Population I and II.</P>
Beaton, Rachael L.,Freedman, Wendy L.,Madore, Barry F.,Bono, Giuseppe,Carlson, Erika K.,Clementini, Gisella,Durbin, Meredith J.,Garofalo, Alessia,Hatt, Dylan,Jang, In Sung,Kollmeier, Juna A.,Lee, Myun American Astronomical Society 2016 The Astrophysical journal Vol.832 No.2
<P>We present an overview of the Carnegie-Chicago Hubble Program, an ongoing program to obtain a 3% measurement of the Hubble constant (H-0) using alternative methods to the traditional Cepheid distance scale. We aim to establish a completely independent route to H-0 using RR Lyrae variables, the tip of the red giant branch (TRGB), and Type Ia supernovae (SNe Ia). This alternative distance ladder can be applied to galaxies of any Hubble type, of any inclination, and, using old stars in low-density environments, is robust to the degenerate effects of metallicity and interstellar extinction. Given the relatively small number of SNe. Ia host galaxies with independently measured distances, these properties provide a great systematic advantage in the measurement of H-0 via the distance ladder. Initially, the accuracy of our value of H-0 will be set by the five Galactic RR Lyrae calibrators with Hubble Space Telescope Fine-Guidance Sensor parallaxes. With Gaia, both the RR Lyrae zero-point and TRGB method will be independently calibrated, the former with at least an order of magnitude more calibrators and the latter directly through parallax measurement of tip red giants. As the first end-to-end 'distance ladder' completely independent of both Cepheid variables and the Large Magellanic Cloud, this path to H-0 will allow for the high-precision comparison at each rung of the traditional distance ladder that is necessary to understand tensions between this and other routes to H-0.</P>
Lee, Myung Gyoon,Jang, In Sung,Beaton, Rachael,Seibert, Mark,Bono, Giuseppe,Madore, Barry American Astronomical Society 2017 ASTROPHYSICAL JOURNAL LETTERS - Vol.835 No.2
<P>Ultra-faint dwarf galaxies (UFDs) are the faintest known galaxies, and due to their incredibly low surface brightness, it is difficult to find them beyond the Local Group. We report a serendipitous discovery of a UFD, Fornax UFD1, in the outskirts of NGC 1316, a giant galaxy in the Fornax cluster. The new galaxy is located at a projected radius of 55 kpc in the south-east of NGC 1316. This UFD is found as a small group of resolved stars in the Hubble Space Telescope images of a halo field of NGC 1316, obtained as part of the Carnegie-Chicago Hubble Program. Resolved stars in this galaxy are consistent with being mostly metal-poor red giant branch (RGB) stars. Applying the tip of the RGB method to the mean magnitude of the two brightest RGB stars, we estimate the distance to this galaxy, 19.0. +/-. 1.3 Mpc. Fornax UFD1 is probably a member of the Fornax cluster. The color-magnitude diagram of these stars is matched by a 12 Gyr isochrone with low metallicity ([Fe/H]approximate to-2.4). Total magnitude and effective radius of Fornax UFD1 are M-V approximate to -7.6 +/- 0.2 mag and r(eff) = 146 +/- 9 pc, which are similar to those of Virgo UFD1 that was discovered recently in the intracluster field of Virgo by Jang & Lee. Fornax UFD1 is the most distant known UFD that is confirmed by resolved stars. This indicates that UFDs are ubiquitous and that more UFDs remain to be discovered in the Fornax cluster.</P>