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- 저자 : Ma Xinying (검색결과 2 건)
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Binyu Wang,Jianpeng Wang,Dingkun Ma,Laili Wang,Fengtao Yang,Xinying Li,Youbo Tan 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
Due to a series of advantages compared with other existing power converters, modular multilevel converters (MMCs) have been widely used in the last decade. However, in some applications, such as the offshore wind power transmission, the MMC submodules (SMs) are subjected to harsh operating environment and adverse mission profiles which can easily lead to failures in the solder layers of IGBT modules. Therefore, the lifetime estimation is very important to predict the reliability of MMC. This paper studies the fundamental-frequency thermal cycles and proposes a lifetime estimation method of MMC SMs based on the combination of finite element analysis (FEA) and the physical lifetime model. This method provides a deeper physical description of the failure mechanism and considers the thermal coupling among the chips, which make the lifetime calculation more accurate. The simulation time of FE in this research is acceptable. The distribution of lifetime is presented in the form of a colorful cloud map, rather than a single number, from which we can know the most vulnerable part of the solder layers. This can help us find the appropriate measures to improve the reliability of MMC SMs. In this paper, the principle and reliability issues of MMC are first analyzed. Second, the loss of the SM is calculated through simulation and curve fitting. Then, a 3D finite element (FE) model of MMC SM is developed and the FE simulation is performed. Finally, the lifetime of the SM is obtained based on the FEA results and Morrow lifetime model.
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Li Xuewen,Liu Zihao,Xu Shendan,Ma Xinying,Zhao Zhezhe,Hu Han,Deng Jiayin,Peng Cheng,Wang Yonglan,Ma Shiqing 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Exosomes derived from bone marrow mesenchymal stem cells (BMSC-exos) have been shown triggering osteogenic differentiation and mineralization of MSCs, but exosomes administered via bolus injections are rapidly sequestered and cleared. Therefore, we considered the implant as a new organ of patient’s body and expected to find a method to treat implant with BMSC-exos in vivo directly.A fusion peptide (PEP), as a drug delivery system (DDS) which contained a titanium-binding peptide (TBP) possessing the ability to selectively bind to the titanium surface and another peptide CP05 being able to capture exosomes expertly, is constructed to modify the titanium surface.Both in vitro and in vivo experiments prove PEP retains the ability to bind titanium and exosome simultaneously, and the DDS gain the ability to target exosomes to titanium implants surface following enhancing osseointegration post-implantation. Moreover, the DDS constructed by exosomes of diverse origins shows the similar combination rate and efficiency of therapy.This drug delivery system demonstrates the concept that EXO-PEP system can offer an accurate and efficient therapy for treating implants with long-term effect.
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