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J. Virtanen,M. Toivanen,T. Toimela,T. Heinonen,S. Tuukkanen 한국물리학회 2020 Current Applied Physics Vol.20 No.1
A proof-of-concept method for measuring cardiac tissue contraction force using an in-house-developed piezoelectric cantilever sensor system is demonstrated. Contracting forces of 7.2–16.6 μN (n=5) were measured from a human cardiac tissue construct. Beating cardiac tissue constructs were monitored in-situ under a microscope during the contraction force measurements. Development of the measurement method allows very low forces such as the ones that appear in biological small scale systems to be determined.