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RISS 인기검색어
- 검색키워드
- 저자 : M. A. Odeniyi (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Matrix Properties of a New Plant Gum in Controlled Drug Delivery
Kalu, V.D.,Jaiyeoba, K.T.,Odeniyi, M.A. 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.7
A new plant gum, Okra (extracted from the pods of Hibiscus esculentus), has been evaluated as a controlled-release agent in modified release matrices, in comparison with sodium carboxymethyl cellulose (NaCMC) and hydroxypropylmethyl cellulose (HPMC), using Paracetamol as a model drug. Tablets were produced by direct compression and the in-vitro drug release was assessed in conditions mimicking the gastro intestinal system, for 6 h. Okra gum matrices provided a controlled-release of Paracetamol for more than 6 h and the release rates followed time-independent kinetics. The release rates were dependent on the concentration of the drug present in the matrix. The addition of tablet excipients, lactose and Avicel, altered the dissolution profile and the release kinetics. Okra gum compared favourably with NaCMC, and a combination of Okra gum and NaCMC, or on further addition of HPMC resulted in near zero-order release of paracetamol from the matrix tablet. The results indicate that Okra gum matrices could be useful in the formulation of sustained-release tablets for up to 6 h.
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J. O. Ayorinde,O. A. Itiola,M. A. Odeniyi 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.3
A work has been done to study the effects ofmaterial properties and compression speed on microbialsurvival and tensile strength in diclofenac tablet formulations. Tablets were produced from three formulationscontaining diclofenac and different excipients (DC, DL andDDCP). Two types of machines (Hydraulic hand press andsingle punch press), which compress the tablets at differentspeeds, were used. The compression properties of thetablets were analyzed using Heckel and Kawakita equations. A 3-dimensional plot was produced to determine therelationship between the tensile strength, compressionspeed and percentage survival of Bacillus subtilis in thediclofenac tablets. The mode of consolidation of diclofenacwas found to depends on the excipient used in the formulation. DC deformed mainly by plastic flow with the lowestPy and Pk values. DL deformed plastically at the initialstage, followed by fragmentation at the later stage ofcompression, whereas DDCP deformed mainly by fragmentationwith the highest Py and Pk values. The ranking ofthe percentage survival of B. subtilis in the formulationswas DDCP[DL[DC, whereas the ranking of the tensilestrength of the tablets was DDCP[DL[DC. Tabletsproduced on a hydraulic hand press with a lower compressionspeed had a lower percentage survival of microbialcontaminants than those produced on a single punchpress, which compressed the tablets at a much higherspeed. The mode of consolidation of the materials and thespeed at which tablet compression is carried out haveeffects on both the tensile strength of the tablets and theextent of destruction of microbial contaminants in diclofenactablet formulations.
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Matrix Properties of a New Plant Gum in Controlled Drug Delivery
V. D. Kalu,M. A. Odeniyi,K. T. Jaiyeoba 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.7
A new plant gum, Okra (extracted from the pods of Hibiscus esculentus), has been evaluated as a controlled-release agent in modified release matrices, in comparison with sodium carboxymethyl cellulose (NaCMC) and hydroxypropylmethyl cellulose (HPMC), using Paracetamol as a model drug. Tablets were produced by direct compression and the in-vitro drug release was assessed in conditions mimicking the gastro intestinal system, for 6 h. Okra gum matrices provided a controlled-release of Paracetamol for more than 6 h and the release rates followed time-independent kinetics. The release rates were dependent on the concentration of the drug present in the matrix. The addition of tablet excipients, lactose and Avicel, altered the dissolution profile and the release kinetics. Okra gum compared favourably with NaCMC, and a combination of Okra gum and NaCMC, or on further addition of HPMC resulted in near zeroorder release of paracetamol from the matrix tablet. The results indicate that Okra gum matrices could be useful in the formulation of sustained-release tablets for up to 6 h.
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