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Factors affecting bone mineral density in children and adolescents with secondary osteoporosis
Jang Min Jeong,Shin Chungwoo,Kim Seongkoo,Lee Jae Wook,Chung Nack-Gyun,Cho Bin,Jung Min Ho,Suh Byung-Kyu,Ahn Moon Bae 대한소아내분비학회 2023 Apem Vol.28 No.1
Purpose: This study aimed to investigate the clinical factors associated with bone mineral density (BMD) among children and adolescents with osteoporosis secondary to treatment for underlying clinical conditions.Methods: We retrospectively reviewed the medical records of patients aged 10–18 years and evaluated them for lumbar spine BMD (LSBMD) after treatment for underlying diseases, including hemato-oncologic, rheumatologic system, and inflammator y bowel diseases. LSBMD measured by dual-energy x-ray absorptiometry (DXA) performed from March 2019 to March 2021 was evaluated. We analyzed 117 patients who underwent initial DXA after treatment for underlying diseases.Results: Subjects in this study had multiple underlying diseases: hemato-oncologic (78.6%), rheumatologic (11.1%), and inflammatory bowel diseases (10.3%). There was no significant association between the z-score and bone metabolic markers (P>0.05). However, higher cumulative glucocorticoid (GC) dose significantly reduced LSBMD z-score (<i>P</i>=0.029). Moreover, the association between cumulative dose of GC and initial z-score of LSBMD was significant in logarithmic regression analysis (<i>P</i>=0.003, R<sup>2</sup>=0.149). GC accumulation was a significant risk factor for vertebral fracture when the initial BMD was evaluated after treatment (<i>P</i>=0.043). Bone metabolic markers did not significantly influence the risk of vertebral fracture.Conclusion: Initial bone mass density of the lumbar spine evaluated after long-term GC use for underlying diseases is a predictor of further vertebral fractures.
Jang, Hye Jung,Park, Sung-Bin,Bedair, Tarek M.,Oh, Min-Kyu,Ahn, Dong-June,Park, Wooram,Joung, Yoon Ki,Han, Dong Keun Elsevier 2018 Journal of industrial and engineering chemistry Vol.59 No.-
<P><B>Abstract</B></P> <P>Five different shapes of magnesium hydroxide (Mg(OH)<SUB>2</SUB>) particles (Plate-S, Plate-N, Disk, Whisker, and Fiber) were synthesized and added to biopolymer (i.e., Poly(lactic-co-glycolic acid) (PLGA)) composite to improve their mechanical and biological properties. The PLGA composite films including Mg(OH)<SUB>2</SUB> particles were prepared by a solvent casting method. Their mechanical and biological properties were compared according to the composites containing different shapes of Mg(OH)<SUB>2</SUB> particles. Among them, the fiber shape of Mg(OH)<SUB>2</SUB> provided the highest mechanical strength, and anti-inflammation and anti-bacterial activity to PLGA films among other forms. This study demonstrated a new strategy for the design of biomaterials by controlling the form of inorganic additives.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Hyung-Kyu Kim,Sol-Moon Na,Dong-June Lee,Ulziijargal Bayarsaikhan,Jae-Ho Ko,Tak-Gi Lee,Yeong-Bin Cha,Chang-Moon Jang,Yang-Seop Bae 한국응용곤충학회 2018 한국응용곤충학회 학술대회논문집 Vol.2018 No.04
The family Tischeriidae belongs to superfamily Tischerioidea, comprising four genera and 115 species. Tischeriidae is known as a leafminer, Tischeriid larvae feed between the leaves of the host plants through all instars. In Korea, two genera and four species have been recorded. recently, Sohn (2007) reported one species and Byun et al (2009) arranged checklist of Tischeriidae. In the present study, we provided checklist of this family, including a newly recorded species from Korea. Brief descriptions of species and illustration of adult and genitalia are provided.
Two newly recorded species of Tischeriidae (Lepidoptera: Tischerioidea) from Korea
Hyeong-Kyu Kim,Ulziijargal Bayarsaikhan,나솔문,Dong-June Lee,Jae-Ho Ko,이탁기,Yeong-Bin Cha,Chang-Moon Jang,Yang-Seop Bae 국립중앙과학관 2019 Journal of Asia-Pacific Biodiversity Vol.12 No.2
Two species of Tischeriidae, Tischeria decidua siorkionla (Kozlov, 1986) and Coptotriche minuta (Diškus & Stonis, 2014) are newly recorded in Korea. Photographs of adults, genitalia and host plants are provided, as well as redescriptions of those two species. The checklist of Korean Tischeriidae is updated.
Higher Plasma Thrombospondin-1 Levels in Patients With Coronary Artery Disease and Diabetes Mellitus
Choi, Kyu-Young,Kim, Dong-Bin,Kim, Myung-Jun,Kwon, Bum-June,Chang, Seo-Yoon,Jang, Sung-Won,Cho, Eun-Joo,Rho, Tai-Ho,Kim, Jae-Hyung The Korean Society of Cardiology 2012 Korean Circulation Journal Vol.42 No.2
<P><B>Background and Objectives</B></P><P>Thrombospondin-1 (TSP-1) is associated with atherosclerosis in animals with diabetes mellitus (DM). But, no study has investigated the role of TSP-1 in human atherosclerosis. This study investigated the relationship among plasma TSP-1 concentration, DM, and coronary artery disease (CAD).</P><P><B>Subjects and Methods</B></P><P>The study involved 374 consecutive subjects with suspected CAD, who had undergone coronary angiography to evaluate effort angina. Patients were divided into four groups as follows: DM(-) and CAD(-), DM(-) and CAD(+), DM(+) and CAD(-), and DM (+) and CAD(+).</P><P><B>Results</B></P><P>We found that plasma TSP-1 levels were higher in patients with DM(+) and CAD(+) (n=103) than those in other patients (n=271) (p<0.01). A multivariate analysis showed that male gender {odds ratio (OR), 2.728; 95% confidence interval (CI), 1.035-7.187}, high density lipoprotein-cholesterol (OR, 0.925; 95% CI, 0.874-0.980), glycated hemoglobin (OR, 1.373; 95% CI, 1.037-1.817), and plasma TSP-1 (OR, 1.004; 95% CI, 1.000-1.008) levels were independently associated with the presence of CAD in patients with DM.</P><P><B>Conclusion</B></P><P>Plasma TSP-1 levels were higher in patients with DM(+) and CAD(+) than those in other patients, and plasma TSP-1 levels were independently associated with the presence of CAD in patients with DM. These findings show a possible link between human plasma TSP-1 concentration and CAD in patients with DM.</P>