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김효언,윤규호,전인성,신재명,한광홍,배정호 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.1
Odontomas are odontogenic harmatomas which are composed of hard dental tissue. This lesion is composed of more than one type of tissue and, for this reason, has been called a composite odontoma. Odontogenic cysts are derived from epithelium associated with the development of the dental apparatus. Dentigerous cyst originated after the crown has been completely formed by accumulation of fluid between the reduced enamel epithelium and the crown. It also associated with crown of impacted tooth. Cystic odontomas are closely similar to dentigerous cysts clinically and radiologically. Treatment of choice is total removal(enucleation) or decompression(marsupialization). We represent two cases of Cystic odontomas with literature review in 69-year old male and 55-year old female occured in anterior maxilla. The leisions were successfully treated by marsupializaion.
Kim, Beom Jin,Kim, Hyun-Soo,Song, Hyun Joo,Chung, Il-Kwun,Kim, Gwang Ha,Kim, Byung-Wook,Shim, Ki-Nam,Jeon, Seong Woo,Jung, Yun Jin,Yang, Chang-Hun,Kim, Ji Hyun,Kim, Tae Ho,Kim, Sang Gyun,Shin, Woon Ge The Korean Academy of Medical Sciences 2016 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.31 No.8
<P>Eradication of <I>Helicobacter pylori</I> using first-line therapy is becoming less effective. Subjects who had been treated for <I>H. pylori</I> infection were prospectively enrolled through an on-line database registry from October 2010 to December 2012. Demographic data, detection methods, treatment indication, regimens, durations, compliance, adverse events, and eradication results for <I>H. pylori</I> infection were collected. Data of 3,700 patients from 34 hospitals were analyzed. The overall eradication rate of the first-line therapy was 73.0%. Eradication failure was significantly associated with old age, concomitant medication, and comorbidity. Regional differences in eradication rates were observed. The most common first-line therapy was proton pump inhibitor-based triple therapy (standard triple therapy, STT) for 7 days (86.8%). The eradication rates varied with regimens, being 73% in STT, 81.8% in bismuth-based quadruple therapy, 100% in sequential therapy, and 90.3% in concomitant therapy. The eradication rate in treatment-naïve patients was higher than that in patients previously treated for <I>H. pylori</I> infection (73.8% vs. 58.5%, <I>P</I> < 0.001). The overall eradication rate for second-line therapy was 84.3%. There was no statistical difference in eradication rates among various regimens. <I>H. pylori</I> eradication rate using STT is decreasing in Korea and has become sub-optimal, suggesting the need for alternative regimens to improve the efficacy of first-line therapy for <I>H. pylori</I> infection.</P>
Kim, Dae Hwan,Shin, Nari,Kim, Gwang Ha,Song, Geum Am,Jeon, Tae-Yong,Kim, Dong-Heon,Lauwers, Gregory Y,Park, Do Youn American Medical Association 2013 Archives of pathology & laboratory medicine Vol.137 No.8
<P>The clinical validity of mucin expression in gastric cancer is debated. Whereas several reports demonstrate a correlation between mucin expression and prognosis, others deny such an association.</P>
( Gwang Ha Kim ),( Hang Lak Lee ),( Moon Kyung Joo ),( Hong Jun Park ),( Sung Woo Jung ),( Ok-jae Lee ),( Hyungkil Kim ),( Hoon Jai Chun ),( Soo Teik Lee ),( Ji Won Kim ),( Han Ho Jeon ),( Il-kwun Chu 대한간학회 2021 Gut and Liver Vol.15 No.6
Background/Aims: The mucoprotective drug rebamipide is used to treat gastritis and peptic ulcers. We compared the efficacy of Mucosta<sup>Ⓡ</sup> (rebamipide 100 mg) and its new formulation, AD-203 (rebamipide 150 mg), in treating erosive gastritis. Methods: This double-blind, active control, noninferiority, multicenter, phase 3 clinical trial randomly assigned 475 patients with endoscopically proven erosive gastritis to two groups: AD-203 twice daily or Mucosta<sup>Ⓡ</sup> thrice daily for 2 weeks. The intention-to-treat (ITT) analysis included 454 patients (AD-203, n=229; Mucosta<sup>Ⓡ</sup>, n=225), and the per-protocol (PP) analysis included 439 patients (AD-203, n=224; Mucosta<sup>Ⓡ</sup>, n=215). The posttreatment assessments included the primary (erosion improvement rate) and secondary endpoints (erosion and edema cure rates; improvement rates of redness, hemorrhage, and gastrointestinal symptoms). Drug-related adverse events were evaluated. Results: According to the ITT analysis, the erosion improvement rates (posttreatment) in AD-203-treated and Mucosta<sup>Ⓡ</sup>-treated patients were 39.7% and 43.8%, respectively. According to the PP analysis, the erosion improvement rates (posttreatment) in AD-203-treated and Mucosta<sup>Ⓡ</sup>-treated patients were 39.3% and 43.7%, respectively. The one-sided 97.5% lower limit for the improvement rate difference between the study groups was -4.01% (95% confidence interval [CI], -13.09% to 5.06%) in the ITT analysis and -4.44% (95% CI, -13.65% to 4.78%) in the PP analysis. The groups did not significantly differ in the secondary endpoints in either analysis. Twenty-four AD-203-treated and 20 Mucosta<sup>Ⓡ</sup>-treated patients reported adverse events but no serious adverse drug reactions; both groups presented similar adverse event rates. Conclusions: The new formulation of rebamipide 150 mg (AD-203) twice daily was not inferior to rebamipide 100 mg (Mucosta<sup>Ⓡ</sup>) thrice daily. Both formulations showed a similar efficacy in treating erosive gastritis. (Gut Liver 2021;15:841-850)
Kim, Gwang Ha,Park, Do Youn,Kida, Mitsuhiro,Kim, Dae Hwan,Jeon, Tae Yong,Kang, Hyun Jeong,Kim, Dong Uk,Choi, Cheol Woong,Lee, Bong Eun,Heo, Jeong,Song, Geun Am Blackwell Publishing Asia 2010 Journal of gastroenterology and hepatology Vol.25 No.3
<P><B>Abstract</B></P><P><B>Background and Aim: </B> The development of endoscopic treatment, such as endoscopic submucosal dissection, extends the indications for endoscopic resection in patients with early gastric cancer (EGC). Endoscopic ultrasonography (EUS) is the first‐choice imaging modality for determining the depth of invasion of gastric cancer. The aim of the present study was to prospectively assess the accuracy of EUS for determining the depth of EGC, according to the accepted/extended indications.</P><P><B>Methods: </B> We prospectively included a total of 181 lesions in 178 patients, with an endoscopic diagnosis of EGC, who underwent EUS for staging the depth of tumor invasion using a 20‐MHz catheter probe. We investigated the accuracy of EUS for determining the depth of endoscopically‐suspected EGC and then analyzed the difference in the accuracy of EUS according to the accepted/extended indications.</P><P><B>Results: </B> Of the 178 patients, five patients were dropped because of the absence of final histological results. For the 176 lesions in 173 patients, the accuracy of EUS assessment for the depth of tumor invasion was 80.7% (142 of 176 lesions). The accuracy of EUS for the lesions with accepted indications and with extended indications was 97.6% (40 of 41 lesions) and 83.6% (46 of 57 lesions), respectively (<I>P</I> = 0.040). Of the lesions with extended indications, the accuracy of EUS decreased especially for the lesions with ulceration and those with minute submucosal invasion (79.2% and 42.9%, respectively).</P><P><B>Conclusions: </B> The accuracy of EUS for the lesions with the extended indications was lower than that for the lesions with the accepted indications. In particular, lesions with ulceration and minute submucosal invasion should be carefully considered prior to endoscopic treatment by pretreatment EUS staging.</P>
Kim, Juseong,Jang, Inseok,Song, Gwang Yeom,Kim, Wan-Ho,Jeon, Sie-Wook,Kim, Jae-Pil Elsevier 2018 The Journal of physics and chemistry of solids Vol.116 No.-
<P><B>Abstract</B></P> <P>The surface property of moisture-sensitive K<SUB>2</SUB>SiF<SUB>6</SUB>:Mn<SUP>4+</SUP> (KSF) as a red-emitting phosphor was controlled through dry-type surface modification in order to improve the photo-performance and reliability of lighting-emitting diode (LED). The phosphor surface was modified with silane coupling agents having different carbon chain length by plasma-assisted method. Comparing between as-prepared and modified KSF, water-resistance and photo-emission efficiency were enhanced due to the formation of hydrophobic shell and the elimination of surface quenching sites. Moreover, the dispersibility of phosphor was increased as increasing the carbon chain length of silane because the interfacial affinity between phosphor and encapsulant was improved. After fabricating LED device, the enhancement of photo-performance and long-term reliability could be successfully achieved in LED device with modified phosphor. It is attributed to that the degradation of phosphor efficiency by moisture was suppressed and heat dissipation in LED PKG was improved through the surface modification.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Moisture-vulnerable K<SUB>2</SUB>SiF<SUB>6</SUB>:Mn<SUP>2+</SUP> was coated with hydrophobic shell by dry-type method. </LI> <LI> The water resistance was improved via surface modification. </LI> <LI> The dispersibility phosphor was enhanced by varying the surface property. </LI> <LI> The enhancement of photo-performance of LED device was achieved. </LI> <LI> The reliability of LED device could be successfully improved. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Controlling the surface property of K<SUB>2</SUB>SiF<SUB>6</SUB>:Mn<SUP>4+</SUP>.</P> <P>[DISPLAY OMISSION]</P>
Erlotinib Induced Trichomegaly of the Eyelashes
Jeon, Sang-Hoon,Ryu, Jeong-Seon,Choi, Gwang-Seong,Kim, Jung-Soo,Kwon, Hea-Yoon,Kim, Min-Su,Nam, Hae-Seong,Cho, Jae-Hwa,Kwak, Seung-Min,Lee, Hong Lyeol,Kim, Hyun-Jung,Hong, Geun-Jeong The Korean Academy of Tuberculosis and Respiratory 2013 Tuberculosis and Respiratory Diseases Vol.74 No.1
Epithelial growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been widely used for non-small-cell lung cancer patients. Its untoward cutaneous effects are largely well known and developed in many patients treated with EGFR TKIs. However trichomegaly of eyelash is rarely reported. Although trichomegaly is not a drug-limiting side effect, it could be troublesome of continuing the treatment because of cosmetic issue or eyeball irritation by long eyelashes. Therefore clinicians are needed to pay attention to this uncommon effect. We herein describe erlotinib induced trichomegaly of eyelashes in a woman with adenocarcinoma of the lung.
Irbesartan prevents myocardial remodeling in experimental thyrotoxic cardiomyopathy.
Kim, Bo Hyun,Cho, Kyoung Im,Kim, Seong Man,Kim, Jee-Yeon,Choi, Bo Gwang,Kang, Ji Hyun,Jeon, Yun Kyung,Kim, Sang Soo,Kim, Seong-Jang,Kim, Yong Ki,Kim, In Joo Japan Endocrine Society 2012 Endocrine journal Vol.59 No.10
<P>This study evaluated the effects of irbesartan and propranolol on thyroid hormone (TH)-induced cardiac functional and structural remodeling. A rat model of thyrotoxicosis was established by daily intraperitoneal injections of L-thyroxine (T(4), 100 μg/kg) for 4 weeks. Forty Sprague-Dawley rats were randomly divided into four groups (n = 10 each): control group, T(4) group (T(4) alone), T(4) plus irbesartan group (T(4)-Irb, 30 mg/kg), and T(4) plus propranolol group (T(4)-Pro, 0.5mg/mL of drinking water). Cardiac chamber size and functional parameters were measured by echocardiography and cardiomyocyte diameter. Heart rate (HR) and cardiac fibrosis were determined. T(4) alone showed significantly increased HR and cardiomyocyte width (25.0 1.77 vs. 18.8 0.84 μm, P < 0.001) with fibrosis, reduced left ventricle (LV) longitudinal strain (S(long); -16.0 6.27 vs. -22.7 5.19 %, P < 0.001) compared with control. When compared with T(4) alone, T(4)-Irb showed significantly improved LV S(long) (-21.4 1.84 vs. -16.0 6.27 %, P =0.017) and reduced cardiomyocyte width (21.0 1.0 vs. 25.0 1.77 μm, P =0.002) with comparable HR (458.4 24.3 vs. 486.6 30.1 bpm, P = 0.086). However, T(4)-Pro showed significantly reduced HR with improved LV S(long) without alteration of cardiomyocyte width and fibrosis compared with T(4) alone. In conclusion, renin-angiotensin system (RAS) blocking by irbesartan could significantly attenuate TH-induced cardiac structural and functional remodeling. However, HR reduction by propranolol could not alternate structural remodeling, which may implicate the RAS as having an important role in thyrotoxic cardiomyopathy beyond tachycardia.</P>
한국성인 제2대구치 생존여부에 영향을 미치는 요인에 대한 로지스틱 회귀분석
김광석 ( Gwang Seok Kim ),이해진 ( Hae Jin Lee ),김영삼 ( Young Sam Kim ),전재규 ( Jae Gyu Jeon ),장기완 ( Kee Wan Chang ) 대한예방치과·구강보건학회 2013 大韓口腔保健學會誌 Vol.37 No.4
Objectives: The purpose of this study was to analyze the factors affecting the survival of permanent second molars in Korean adults using logistic regression analysis. Methods: This National survey was conducted in 2006 and was performed in 3 stages comprising stratified sampling, age, sex, and region. This study included 15,777 persons, aged 2-95 years. The raw data was analyzed using SPSS software v12.0 and the relationship between the 9 variables and the tooth survival rate was analyzed by frequency and cross-tabulation. Logistic regression analysis using the functional weightage of the age, sex, regions of the Korean population was also performed. Entry was at level of 5%, while removal was at a 10% level during logistic regression analysis. The nine variables used for analysis were age, socio-economic level, monthly family income, sex, frequency of toothbrushing per day, diabetes, educational level, smoking, and frequency of snack intake per day. Results & Conclusions: The most significant explanatory variables, in increasing order of significance, were age, socioeconomic status, and diabetes. As age increased by 10 years, the survival rate of second molars decreased at a slow rate 7.5% to 9.5%. The survival rate of the second molar of an individual engaged in activities, such as farming, stock breeding, and fishing decreased from 64.4% to 78.8% as compared to people at high positions in various companies and in society.